Signaling Peptide SpoV Is Essential for <i>Streptococcus pyogenes</i> Virulence, and Prophylaxis with Anti-SpoV Decreases Disease Severity
Streptococcal peptide of virulence (SpoV) is a <i>Streptococcus pyogenes</i> (group A streptococcus (GAS))-specific peptide that is important for GAS survival in murine blood, and the expression of the virulence factors streptolysin O (<i>slo</i>) and streptolysin S (<i>...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/11/2321 |
| _version_ | 1797509247616942080 |
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| author | Andrea L. Herrera Michael S. Chaussee |
| author_facet | Andrea L. Herrera Michael S. Chaussee |
| author_sort | Andrea L. Herrera |
| collection | DOAJ |
| description | Streptococcal peptide of virulence (SpoV) is a <i>Streptococcus pyogenes</i> (group A streptococcus (GAS))-specific peptide that is important for GAS survival in murine blood, and the expression of the virulence factors streptolysin O (<i>slo</i>) and streptolysin S (<i>sagA</i>). We used a <i>spoV</i> mutant in isolate MGAS315 to assess the contribution of the SpoV peptide to virulence by using a murine model of invasive disease and an ex vivo human model (Lancefield assay). We then used antibodies to SpoV in both models to evaluate their ability to decrease morbidity and mortality. Results showed that SpoV is essential for GAS virulence, and targeting the peptide has therapeutic potential. |
| first_indexed | 2024-03-10T05:15:01Z |
| format | Article |
| id | doaj.art-ac3e5d64c9f644fa80047f3a0d02ae28 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T05:15:01Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-ac3e5d64c9f644fa80047f3a0d02ae282023-11-23T00:29:40ZengMDPI AGMicroorganisms2076-26072021-11-01911232110.3390/microorganisms9112321Signaling Peptide SpoV Is Essential for <i>Streptococcus pyogenes</i> Virulence, and Prophylaxis with Anti-SpoV Decreases Disease SeverityAndrea L. Herrera0Michael S. Chaussee1Division of Basic Biomedical Sciences, The Sanford School of Medicine, The University of South Dakota, Vermillion, SD 57069, USADivision of Basic Biomedical Sciences, The Sanford School of Medicine, The University of South Dakota, Vermillion, SD 57069, USAStreptococcal peptide of virulence (SpoV) is a <i>Streptococcus pyogenes</i> (group A streptococcus (GAS))-specific peptide that is important for GAS survival in murine blood, and the expression of the virulence factors streptolysin O (<i>slo</i>) and streptolysin S (<i>sagA</i>). We used a <i>spoV</i> mutant in isolate MGAS315 to assess the contribution of the SpoV peptide to virulence by using a murine model of invasive disease and an ex vivo human model (Lancefield assay). We then used antibodies to SpoV in both models to evaluate their ability to decrease morbidity and mortality. Results showed that SpoV is essential for GAS virulence, and targeting the peptide has therapeutic potential.https://www.mdpi.com/2076-2607/9/11/2321<i>Streptococcus pyogenes</i>SpoVvirulenceiGASantibody therapy |
| spellingShingle | Andrea L. Herrera Michael S. Chaussee Signaling Peptide SpoV Is Essential for <i>Streptococcus pyogenes</i> Virulence, and Prophylaxis with Anti-SpoV Decreases Disease Severity Microorganisms <i>Streptococcus pyogenes</i> SpoV virulence iGAS antibody therapy |
| title | Signaling Peptide SpoV Is Essential for <i>Streptococcus pyogenes</i> Virulence, and Prophylaxis with Anti-SpoV Decreases Disease Severity |
| title_full | Signaling Peptide SpoV Is Essential for <i>Streptococcus pyogenes</i> Virulence, and Prophylaxis with Anti-SpoV Decreases Disease Severity |
| title_fullStr | Signaling Peptide SpoV Is Essential for <i>Streptococcus pyogenes</i> Virulence, and Prophylaxis with Anti-SpoV Decreases Disease Severity |
| title_full_unstemmed | Signaling Peptide SpoV Is Essential for <i>Streptococcus pyogenes</i> Virulence, and Prophylaxis with Anti-SpoV Decreases Disease Severity |
| title_short | Signaling Peptide SpoV Is Essential for <i>Streptococcus pyogenes</i> Virulence, and Prophylaxis with Anti-SpoV Decreases Disease Severity |
| title_sort | signaling peptide spov is essential for i streptococcus pyogenes i virulence and prophylaxis with anti spov decreases disease severity |
| topic | <i>Streptococcus pyogenes</i> SpoV virulence iGAS antibody therapy |
| url | https://www.mdpi.com/2076-2607/9/11/2321 |
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