Effects of anesthesia on fluid volume kinetics after infusion of colloid solution during blood donation
BackgroundThe fluid kinetics of intravenously infused colloid during inhalation anesthesia and hemorrhage have not been investigated. We therefore assessed fluid space changes during infusion of hydroxyethyl starch solution after hemorrhage in conscious and desflurane-anesthetized individuals.Method...
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Korean Society of Anesthesiologists
2010-06-01
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| Series: | Korean Journal of Anesthesiology |
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| Online Access: | http://ekja.org/upload/pdf/kjae-58-514.pdf |
| _version_ | 1818211712214499328 |
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| author | Eun Ho Lee Sun-Key Kim Young Goo Yeo Kyu Taek Choi |
| author_facet | Eun Ho Lee Sun-Key Kim Young Goo Yeo Kyu Taek Choi |
| author_sort | Eun Ho Lee |
| collection | DOAJ |
| description | BackgroundThe fluid kinetics of intravenously infused colloid during inhalation anesthesia and hemorrhage have not been investigated. We therefore assessed fluid space changes during infusion of hydroxyethyl starch solution after hemorrhage in conscious and desflurane-anesthetized individuals.MethodsFollowing the donation of 400 ml of blood, 500 ml of hydroxyethyl starch solution was infused over 20 minutes into wakeful and desflurane-anesthetized volunteers. Blood was repeatedly sampled to measure hemoglobin concentration, a marker of plasma dilution, and fluid kinetic analysis was performed to evaluate changes in fluid space.ResultsUsing a fluid kinetic model, we found that the mean volume of fluid space was 7,724 ± 1,788 ml in wakeful volunteers and 6,818 ± 4,221 ml in anesthetized volunteers, and the elimination rate constants were 7.1 ± 3.5 ml/min and 19.4 ± 4.6 ml/min, respectively.ConclusionsInfusion of colloid after mild hemorrhage resulted in similar expansions of plasma volume in desflurane-anesthetized and conscious individuals. During anesthesia, however, the expansion of plasma volume by colloid was decreased and of shorter duration than observed in conscious patients. |
| first_indexed | 2024-12-12T05:36:51Z |
| format | Article |
| id | doaj.art-ac40b10f0c4e425789509b3cdf866576 |
| institution | Directory Open Access Journal |
| issn | 2005-6419 2005-7563 |
| language | English |
| last_indexed | 2024-12-12T05:36:51Z |
| publishDate | 2010-06-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Korean Journal of Anesthesiology |
| spelling | doaj.art-ac40b10f0c4e425789509b3cdf8665762022-12-22T00:36:07ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632010-06-0158651452010.4097/kjae.2010.58.6.5146913Effects of anesthesia on fluid volume kinetics after infusion of colloid solution during blood donationEun Ho Lee0Sun-Key Kim1Young Goo Yeo2Kyu Taek Choi3Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.Hanyang University College of Engineering, Seoul, Korea.Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.BackgroundThe fluid kinetics of intravenously infused colloid during inhalation anesthesia and hemorrhage have not been investigated. We therefore assessed fluid space changes during infusion of hydroxyethyl starch solution after hemorrhage in conscious and desflurane-anesthetized individuals.MethodsFollowing the donation of 400 ml of blood, 500 ml of hydroxyethyl starch solution was infused over 20 minutes into wakeful and desflurane-anesthetized volunteers. Blood was repeatedly sampled to measure hemoglobin concentration, a marker of plasma dilution, and fluid kinetic analysis was performed to evaluate changes in fluid space.ResultsUsing a fluid kinetic model, we found that the mean volume of fluid space was 7,724 ± 1,788 ml in wakeful volunteers and 6,818 ± 4,221 ml in anesthetized volunteers, and the elimination rate constants were 7.1 ± 3.5 ml/min and 19.4 ± 4.6 ml/min, respectively.ConclusionsInfusion of colloid after mild hemorrhage resulted in similar expansions of plasma volume in desflurane-anesthetized and conscious individuals. During anesthesia, however, the expansion of plasma volume by colloid was decreased and of shorter duration than observed in conscious patients.http://ekja.org/upload/pdf/kjae-58-514.pdffluid therapygeneral anesthesiahemorrhagehydroxyethyl starch solution |
| spellingShingle | Eun Ho Lee Sun-Key Kim Young Goo Yeo Kyu Taek Choi Effects of anesthesia on fluid volume kinetics after infusion of colloid solution during blood donation Korean Journal of Anesthesiology fluid therapy general anesthesia hemorrhage hydroxyethyl starch solution |
| title | Effects of anesthesia on fluid volume kinetics after infusion of colloid solution during blood donation |
| title_full | Effects of anesthesia on fluid volume kinetics after infusion of colloid solution during blood donation |
| title_fullStr | Effects of anesthesia on fluid volume kinetics after infusion of colloid solution during blood donation |
| title_full_unstemmed | Effects of anesthesia on fluid volume kinetics after infusion of colloid solution during blood donation |
| title_short | Effects of anesthesia on fluid volume kinetics after infusion of colloid solution during blood donation |
| title_sort | effects of anesthesia on fluid volume kinetics after infusion of colloid solution during blood donation |
| topic | fluid therapy general anesthesia hemorrhage hydroxyethyl starch solution |
| url | http://ekja.org/upload/pdf/kjae-58-514.pdf |
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