Effect of Very Early Atorvastatin Initiation for Acute Myocardial Infarction on Creatine Kinase release
Background : It has been suggested that pretreatment with a statin agent prior to myocardial infarction limits myocardial creatine kinase release, and thus may act to limit myocardial infarct size in humans. Objective : To examine the effect of very early statin initiation for acute myocardial infa...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
University of Baghdad/ Al-Kindy College of Medicine
2010-06-01
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| Series: | مجله كليه طب الكندي |
| Subjects: | |
| Online Access: | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/704 |
| _version_ | 1818481357457719296 |
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| author | Faris Abdul Kareem Lewai . S Abdulaziz Adnan A. Al.adeem |
| author_facet | Faris Abdul Kareem Lewai . S Abdulaziz Adnan A. Al.adeem |
| author_sort | Faris Abdul Kareem |
| collection | DOAJ |
| description |
Background : It has been suggested that pretreatment with a statin agent prior to
myocardial infarction limits myocardial
creatine kinase release, and thus may act to
limit myocardial infarct size in humans.
Objective : To examine the effect of very
early statin initiation for acute myocardial
infarction (AMI), to the extent of
myonecrosis as manifested by peak serum
creatine kinase levels.
Methods : Patients with AMI admitted to AlKindy teaching hospital cardiac care unit
from 1st February 2007 to 28th February
2008, who fulfilled the inclusion criteria
cited in the present study, were randomly
assigned into two study groups. The statin
group patients have received a single oral
dose of 40 mg atorvastatin at time of
admission and repeated for the next days
until discharge, patients not receiving statin
were considered as controls, blood samples
were obtained on admission and every 8 h for
another three consecutive samples to identify
peak creatine kinase levels.
Results : Patients who had statin therapy
initiated immediately after hospital
admission have similar peak creatine kinase
concentrations as compared to those not
receiving statin therapy ( P= 0.332).
Conclusion : statin initiation in AMI patients
fails to show any observable effect on
creatine kinase release, the need of an
extended period for the statin agent to
achieve the predictable outcome may suggest
the necessity of statin pretreatment in
patients at high risk for AMI
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| first_indexed | 2024-12-10T11:33:49Z |
| format | Article |
| id | doaj.art-ac42da893ee84141b8691713382db740 |
| institution | Directory Open Access Journal |
| issn | 1810-9543 2521-4365 |
| language | English |
| last_indexed | 2024-12-10T11:33:49Z |
| publishDate | 2010-06-01 |
| publisher | University of Baghdad/ Al-Kindy College of Medicine |
| record_format | Article |
| series | مجله كليه طب الكندي |
| spelling | doaj.art-ac42da893ee84141b8691713382db7402022-12-22T01:50:29ZengUniversity of Baghdad/ Al-Kindy College of Medicineمجله كليه طب الكندي1810-95432521-43652010-06-0161Effect of Very Early Atorvastatin Initiation for Acute Myocardial Infarction on Creatine Kinase releaseFaris Abdul Kareem0Lewai . S Abdulaziz1Adnan A. Al.adeem2Department of Medicine, Al-kindy College of Medicine, University of Baghdad*Department of Biochemistry, Al-kindy College of Medicine, University of Baghdad*Postgraduate candidate, Al-kindy Teaching Hospital. Background : It has been suggested that pretreatment with a statin agent prior to myocardial infarction limits myocardial creatine kinase release, and thus may act to limit myocardial infarct size in humans. Objective : To examine the effect of very early statin initiation for acute myocardial infarction (AMI), to the extent of myonecrosis as manifested by peak serum creatine kinase levels. Methods : Patients with AMI admitted to AlKindy teaching hospital cardiac care unit from 1st February 2007 to 28th February 2008, who fulfilled the inclusion criteria cited in the present study, were randomly assigned into two study groups. The statin group patients have received a single oral dose of 40 mg atorvastatin at time of admission and repeated for the next days until discharge, patients not receiving statin were considered as controls, blood samples were obtained on admission and every 8 h for another three consecutive samples to identify peak creatine kinase levels. Results : Patients who had statin therapy initiated immediately after hospital admission have similar peak creatine kinase concentrations as compared to those not receiving statin therapy ( P= 0.332). Conclusion : statin initiation in AMI patients fails to show any observable effect on creatine kinase release, the need of an extended period for the statin agent to achieve the predictable outcome may suggest the necessity of statin pretreatment in patients at high risk for AMI https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/704AtorvastatinAcute myocardial infarctionCreatine kinaseInfarct size. |
| spellingShingle | Faris Abdul Kareem Lewai . S Abdulaziz Adnan A. Al.adeem Effect of Very Early Atorvastatin Initiation for Acute Myocardial Infarction on Creatine Kinase release مجله كليه طب الكندي Atorvastatin Acute myocardial infarction Creatine kinase Infarct size. |
| title | Effect of Very Early Atorvastatin Initiation for Acute Myocardial Infarction on Creatine Kinase release |
| title_full | Effect of Very Early Atorvastatin Initiation for Acute Myocardial Infarction on Creatine Kinase release |
| title_fullStr | Effect of Very Early Atorvastatin Initiation for Acute Myocardial Infarction on Creatine Kinase release |
| title_full_unstemmed | Effect of Very Early Atorvastatin Initiation for Acute Myocardial Infarction on Creatine Kinase release |
| title_short | Effect of Very Early Atorvastatin Initiation for Acute Myocardial Infarction on Creatine Kinase release |
| title_sort | effect of very early atorvastatin initiation for acute myocardial infarction on creatine kinase release |
| topic | Atorvastatin Acute myocardial infarction Creatine kinase Infarct size. |
| url | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/704 |
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