The Visceral-Fat-Area-to-Hip-Circumference Ratio as a Predictor for Insulin Resistance in a Chinese Population with Type 2 Diabetes
Introduction: Adipose tissue deposited on the viscera is the main culprit in the development of insulin resistance (IR) and cardiometabolic diseases, whereas subcutaneous adipose tissue may have a protective role. This study aimed to propose a new predictive index – the visceral-fat area (VFA)-to-hi...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2022-06-01
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| Series: | Obesity Facts |
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| Online Access: | https://www.karger.com/Article/FullText/525545 |
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| author | Shi Zhang Ya-Ping Huang Jing Li Wen-Hong Wang Min-Ying Zhang Xin-Cheng Wang Jing-Na Lin Chun-Jun Li |
| author_facet | Shi Zhang Ya-Ping Huang Jing Li Wen-Hong Wang Min-Ying Zhang Xin-Cheng Wang Jing-Na Lin Chun-Jun Li |
| author_sort | Shi Zhang |
| collection | DOAJ |
| description | Introduction: Adipose tissue deposited on the viscera is the main culprit in the development of insulin resistance (IR) and cardiometabolic diseases, whereas subcutaneous adipose tissue may have a protective role. This study aimed to propose a new predictive index – the visceral-fat area (VFA)-to-hip-circumference ratio (VHR) and explore its efficacy for prediction of IR in a Chinese population with type 2 diabetes mellitus. Methods: A total of 643 patients with newly diagnosed diabetes were enrolled in this study. Body composition, anthropometrical, and biochemical measurements were performed. IR was defined as homeostatic model assessment of IR (HOMA-IR) > 2.69. The association between VHR and IR was analyzed. Results: Regardless of gender, subjects in the IR group had higher VHR, body mass index (BMI), VFA, body fat percentage, systolic blood pressure, diastolic blood pressure (DBP), fasting blood glucose, fasting insulin, triglyceride (TG), uric acid (UA), homocysteine, and aminotransferases than those in the non-IR group. The other concomitant metabolic disorders were more common in the IR group. Further analysis showed that with the increase of VHR, the levels of HOMA-IR, BMI, VFA, DBP, TG, UA and the prevalence of nonalcoholic fatty-liver disease, hypertension, and hyperuricemia increased continuously (p trend <0.01). The linear trend test showed that VHR and IR remained closely correlated after adjusting for possible confounders (p trend <0.05). The receiver operating characteristic curve analysis showed that the area under the curve was 0.69, and the optimal cutoff of VHR was 0.89 (sensitivity 79.3%, specificity 61.5%). Conclusion: VHR was positively associated with IR regardless of gender, and it might be a reliable predictor for IR. |
| first_indexed | 2024-12-10T16:46:38Z |
| format | Article |
| id | doaj.art-ac4599961ad74cc4b44a446811e21568 |
| institution | Directory Open Access Journal |
| issn | 1662-4025 1662-4033 |
| language | English |
| last_indexed | 2024-12-10T16:46:38Z |
| publishDate | 2022-06-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Obesity Facts |
| spelling | doaj.art-ac4599961ad74cc4b44a446811e215682022-12-22T01:41:02ZengKarger PublishersObesity Facts1662-40251662-40332022-06-011810.1159/000525545525545The Visceral-Fat-Area-to-Hip-Circumference Ratio as a Predictor for Insulin Resistance in a Chinese Population with Type 2 DiabetesShi Zhang0https://orcid.org/0000-0002-5406-4224Ya-Ping Huang1Jing Li2Wen-Hong Wang3Min-Ying Zhang4Xin-Cheng Wang5Jing-Na Lin6Chun-Jun Li7Department of Endocrinology, Health Management Center, Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, ChinaDepartment of Endocrinology, Health Management Center, Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, ChinaDepartment of Endocrinology, Health Management Center, Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, ChinaDepartment of Endocrinology, Health Management Center, Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, ChinaCollege of Medicine, Nankai University, Tianjin, ChinaDepartment of Endocrinology, Health Management Center, Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, ChinaDepartment of Endocrinology, Health Management Center, Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, ChinaDepartment of Endocrinology, Health Management Center, Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, ChinaIntroduction: Adipose tissue deposited on the viscera is the main culprit in the development of insulin resistance (IR) and cardiometabolic diseases, whereas subcutaneous adipose tissue may have a protective role. This study aimed to propose a new predictive index – the visceral-fat area (VFA)-to-hip-circumference ratio (VHR) and explore its efficacy for prediction of IR in a Chinese population with type 2 diabetes mellitus. Methods: A total of 643 patients with newly diagnosed diabetes were enrolled in this study. Body composition, anthropometrical, and biochemical measurements were performed. IR was defined as homeostatic model assessment of IR (HOMA-IR) > 2.69. The association between VHR and IR was analyzed. Results: Regardless of gender, subjects in the IR group had higher VHR, body mass index (BMI), VFA, body fat percentage, systolic blood pressure, diastolic blood pressure (DBP), fasting blood glucose, fasting insulin, triglyceride (TG), uric acid (UA), homocysteine, and aminotransferases than those in the non-IR group. The other concomitant metabolic disorders were more common in the IR group. Further analysis showed that with the increase of VHR, the levels of HOMA-IR, BMI, VFA, DBP, TG, UA and the prevalence of nonalcoholic fatty-liver disease, hypertension, and hyperuricemia increased continuously (p trend <0.01). The linear trend test showed that VHR and IR remained closely correlated after adjusting for possible confounders (p trend <0.05). The receiver operating characteristic curve analysis showed that the area under the curve was 0.69, and the optimal cutoff of VHR was 0.89 (sensitivity 79.3%, specificity 61.5%). Conclusion: VHR was positively associated with IR regardless of gender, and it might be a reliable predictor for IR.https://www.karger.com/Article/FullText/525545hip circumferenceinsulin resistancevisceral-fat area |
| spellingShingle | Shi Zhang Ya-Ping Huang Jing Li Wen-Hong Wang Min-Ying Zhang Xin-Cheng Wang Jing-Na Lin Chun-Jun Li The Visceral-Fat-Area-to-Hip-Circumference Ratio as a Predictor for Insulin Resistance in a Chinese Population with Type 2 Diabetes Obesity Facts hip circumference insulin resistance visceral-fat area |
| title | The Visceral-Fat-Area-to-Hip-Circumference Ratio as a Predictor for Insulin Resistance in a Chinese Population with Type 2 Diabetes |
| title_full | The Visceral-Fat-Area-to-Hip-Circumference Ratio as a Predictor for Insulin Resistance in a Chinese Population with Type 2 Diabetes |
| title_fullStr | The Visceral-Fat-Area-to-Hip-Circumference Ratio as a Predictor for Insulin Resistance in a Chinese Population with Type 2 Diabetes |
| title_full_unstemmed | The Visceral-Fat-Area-to-Hip-Circumference Ratio as a Predictor for Insulin Resistance in a Chinese Population with Type 2 Diabetes |
| title_short | The Visceral-Fat-Area-to-Hip-Circumference Ratio as a Predictor for Insulin Resistance in a Chinese Population with Type 2 Diabetes |
| title_sort | visceral fat area to hip circumference ratio as a predictor for insulin resistance in a chinese population with type 2 diabetes |
| topic | hip circumference insulin resistance visceral-fat area |
| url | https://www.karger.com/Article/FullText/525545 |
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