Drug and cell type-specific regulation of genes with different classes of estrogen receptor beta-selective agonists.

Drug and cell type-specific regulation of genes with different classes of estrogen receptor beta-selective agonists.

Estrogens produce biological effects by interacting with two estrogen receptors, ERalpha and ERbeta. Drugs that selectively target ERalpha or ERbeta might be safer for conditions that have been traditionally treated with non-selective estrogens. Several synthetic and natural ERbeta-selective compoun...

Full description

Bibliographic Details
Main Authors:	Sreenivasan Paruthiyil, Aleksandra Cvoro, Xiaoyue Zhao, Zhijin Wu, Yunxia Sui, Richard E Staub, Scott Baggett, Candice B Herber, Chandi Griffin, Mary Tagliaferri, Heather A Harris, Isaac Cohen, Leonard F Bjeldanes, Terence P Speed, Fred Schaufele, Dale C Leitman
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2009-07-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2707612?pdf=render

Similar Items

Estrogenic plant extracts reverse weight gain and fat accumulation without causing mammary gland or uterine proliferation.
by: Elise F Saunier, et al.
Published: (2011-01-01)

2′,3′,4′-Trihydroxychalcone changes estrogen receptor α regulation of genes and breast cancer cell proliferation by a reprogramming mechanism
by: Candice B. Herber, et al.
Published: (2022-04-01)

Estrogen receptor beta-selective agonists stimulate calcium oscillations in human and mouse embryonic stem cell-derived neurons.
by: Lili Zhang, et al.
Published: (2010-07-01)

Estrogen-Like Effect of Mitotane Explained by Its Agonist Activity on Estrogen Receptor-α
by: Elisa Rossini, et al.
Published: (2021-06-01)

Activity of Estrogen Receptor β Agonists in Therapy-Resistant Estrogen Receptor-Positive Breast Cancer
by: Jharna Datta, et al.
Published: (2022-04-01)

Estrogen receptor β agonist inhibits proliferation of endometrial stromal cells in an estrogen-receptor independent manner
by: Xia Qiong, et al.
Published: (2014-01-01)

Sexually dimorphic metabolic responses mediated by CRF2 receptor during nutritional stress in mice
by: Sreenivasan Paruthiyil, et al.
Published: (2018-11-01)

Phytochemicals and Estrogen-Receptor Agonists from the Aerial Parts of Liriope platyphylla
by: Yu-Chi Tsai, et al.
Published: (2015-04-01)

Identification and analysis of the active phytochemicals from the anti-cancer botanical extract Bezielle.
by: Vivian Chen, et al.
Published: (2012-01-01)

Effect of estrogen receptor β agonists on proliferation and gene expression of ovarian cancer cells
by: Susanne Schüler-Toprak, et al.
Published: (2017-05-01)

Gold Nanoparticles Functionalized with Peptides for Specific Affinity Aggregation Assays of Estrogen Receptors and Their Agonists
by: Yoshiyuki Takatsuji, et al.
Published: (2012-04-01)

Estrogen receptor β agonist ameliorates social deficits in a mouse model of autism
by: ZHANG Ruiyu, et al.
Published: (2019-03-01)

Structure-Based Understanding of Binding Affinity and Mode of Estrogen Receptor α Agonists and Antagonists.
by: Sehan Lee, et al.
Published: (2017-01-01)

Future directions for using estrogen receptor agonists in the treatment of acute and chronic spinal cord injury
by: Swapan K Ray, et al.
Published: (2016-01-01)

Agonistic activity of tamoxifen, a selective estrogen-receptor modulator (SERM), on arthritic ovariectomized mice
by: L.A.S. Silva, et al.
Published: (2017-11-01)

Prediction of selective estrogen receptor beta agonist using open data and machine learning approach
by: Niu AQ, et al.
Published: (2016-07-01)

Estradiol and Estrogen Receptor Agonists Oppose Oncogenic Actions of Leptin in HepG2 Cells.
by: Minqian Shen, et al.
Published: (2016-01-01)

Estrogen agonist genistein differentially influences the cognitive and motor disorders in an ovariectomized animal model of Parkinsonism
by: Elaheh Arbabi, et al.
Published: (2016-12-01)

Potent and Selective Estrogen Receptor-Beta Agonists Which Enhance Memory Consolidation in an Ovariectomized Mouse Model
by: Alicia M. Hanson, et al.
Published: (2019-08-01)

Synthesis and Evaluation of (1,4-Disubstituted)-1,2,3-triazoles as Estrogen Receptor Beta Agonists
by: Edward A. Wetzel, et al.
Published: (2022-08-01)

In Silico Prediction of Heliannuol A, B, C, D, and E Compounds on Estrogen Receptor β Agonists
by: Roihatul Mutiah, et al.
Published: (2021-08-01)

Correction: Future directions for using estrogen receptor agonists in the treatment of acute and chronic spinal cord injury
by: Swapan K Ray, et al.
Published: (2017-01-01)

Metabolic Effect of Estrogen Receptor Agonists on Breast Cancer Cells in the Presence or Absence of Carbonic Anhydrase Inhibitors
by: Anissa Belkaid, et al.
Published: (2016-05-01)

Estrogen receptor hormone agonists limit trauma hemorrhage shock-induced gut and lung injury in rats.
by: Danielle Doucet, et al.
Published: (2010-02-01)

Estrogen-Related Receptor γ Agonist DY131 Ameliorates Lipopolysaccharide-Induced Acute Liver Injury
by: Haoyang Ma, et al.
Published: (2021-04-01)

Gastric corticotropin-releasing factor influences mast cell infiltration in a rat model of functional dyspepsia.
by: Shin-Ichiro Hagiwara, et al.
Published: (2018-01-01)

Cyclopia extracts act as selective estrogen receptor subtype downregulators in estrogen receptor positive breast cancer cell lines: Comparison to standard of care breast cancer endocrine therapies and a selective estrogen receptor agonist and antagonist
by: Folasade R. Olayoku, et al.
Published: (2023-03-01)

In silico and in vitro evaluation of potential agonistic and antagonistic estrogenic and androgenic activities of pure cyanotoxins, microcystin-LR and cylindrospermopsin
by: Antonio Casas-Rodríguez, et al.
Published: (2025-01-01)

Gene expression profiling identifies activated growth factor signaling in poor prognosis (Luminal-B) estrogen receptor positive breast cancer
by: Conus Nelly M, et al.
Published: (2009-06-01)

Estrogen receptor expression in osteoblasts is not enhanced in vitro by low-magnitude high-frequency vibrational stimulation in the absence of estrogen
by: Simon K.H. Chow, et al.
Published: (2016-10-01)

Ovariectomy and subsequent treatment with estrogen receptor agonists tune the innate immune system of the hippocampus in middle-aged female rats.
by: Miklós Sárvári, et al.
Published: (2014-01-01)

G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Mantle Cell Lymphoma Growth in Preclinical Models
by: Lixia Zhou, et al.
Published: (2021-06-01)

Differential Neuroprotection of Selective Estrogen Receptor Agonists against Autonomic Dysfunction and Ischemic Cell Death in Permanent versus Reperfusion Injury
by: Barry J. Connell, et al.
Published: (2011-01-01)

Identification of estrogen receptor agonists among hydroxylated polychlorinated biphenyls using classification-based quantitative structure–activity relationship models
by: Lukman K. Akinola, et al.
Published: (2024-01-01)

The Natural Agonist of Estrogen Receptor β Silibinin Plays an Immunosuppressive Role Representing a Potential Therapeutic Tool in Rheumatoid Arthritis
by: Maria Luisa Dupuis, et al.
Published: (2018-08-01)

Effects of estrogen receptor GPR30 agonist G1 on neuronal apoptosis and microglia polarization in traumatic brain injury rats
by: Meng-Xian Pan, et al.
Published: (2018-08-01)

The G-Protein–Coupled Estrogen Receptor Agonist G-1 Inhibits Proliferation and Causes Apoptosis in Leukemia Cell Lines of T Lineage
by: Liliana Torres-López, et al.
Published: (2022-02-01)

Estrogen and estrogen receptors in kidney diseases
by: Hao-Yang Ma, et al.
Published: (2021-01-01)

Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function
by: Anisha A. Gupte, et al.
Published: (2015-01-01)

SERMs (selective estrogen receptor modulator), acting as estrogen receptor β agonists in hepatocellular carcinoma cells, inhibit the transforming growth factor-α-induced migration via specific inhibition of AKT signaling pathway
by: Rie Matsushima-Nishiwaki, et al.
Published: (2022-01-01)