Hazard identification of dehydroacetic acid and its sodium salt used as food additives based on systematic literature searches
The current study, using a systematic-literature-search approach, was intended to conduct hazard identification for dehydroacetic acid (DHA) and sodium dehydroacetate (DHA-S) which are currently used as food additives in China. DHA and DHA-S belong to the category of low toxic chemicals in terms of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
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The Editorial Office of Chinese Journal of Food Hygiene
2020-09-01
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| Series: | Zhongguo shipin weisheng zazhi |
| Subjects: | |
| Online Access: | http://www.zgspws.com/zgspwszzen/article/abstract/20200522 |
| _version_ | 1797769051866398720 |
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| author | Xiao XIAO Guojun LI Yan SONG Zhou YU Jian JIANG Hongju DU |
| author_facet | Xiao XIAO Guojun LI Yan SONG Zhou YU Jian JIANG Hongju DU |
| author_sort | Xiao XIAO |
| collection | DOAJ |
| description | The current study, using a systematic-literature-search approach, was intended to conduct hazard identification for dehydroacetic acid (DHA) and sodium dehydroacetate (DHA-S) which are currently used as food additives in China. DHA and DHA-S belong to the category of low toxic chemicals in terms of acute toxicity, mainly causing adverse effects in the central nervous system. Its subacute, subchronic and chronic toxicity mainly include significant reduction of body weight and food intake as well as anticoagulant effect. Reproductive development toxicity result show they can decrease body weight and inhibit bone development in offspring. According to the hazard identification result, oral intake of dehydroacetic acid and its sodium salt can produce a variety of toxic effects above certain doses. Further study is needed to determine the acceptable daily intake of DHA and its sodium salt and provide scientific evidence for safely use of these compounds as food additives. |
| first_indexed | 2024-03-12T21:03:16Z |
| format | Article |
| id | doaj.art-ac4a1f0d66574b7a899c631acf34348b |
| institution | Directory Open Access Journal |
| issn | 1004-8456 |
| language | zho |
| last_indexed | 2024-03-12T21:03:16Z |
| publishDate | 2020-09-01 |
| publisher | The Editorial Office of Chinese Journal of Food Hygiene |
| record_format | Article |
| series | Zhongguo shipin weisheng zazhi |
| spelling | doaj.art-ac4a1f0d66574b7a899c631acf34348b2023-07-31T02:32:02ZzhoThe Editorial Office of Chinese Journal of Food HygieneZhongguo shipin weisheng zazhi1004-84562020-09-01320558258810.13590/j.cjfh.2020.05.0211004-8456(2020)05-0582-07Hazard identification of dehydroacetic acid and its sodium salt used as food additives based on systematic literature searchesXiao XIAO0Guojun LI1Yan SONG2Zhou YU3Jian JIANG4Hongju DU5China National Center for Food Safety Risk Assessment, Beijing 100022, ChinaBeijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention, Beijing 100013, ChinaChina National Center for Food Safety Risk Assessment, Beijing 100022, ChinaChina National Center for Food Safety Risk Assessment, Beijing 100022, ChinaAnhui Provincial Center for Disease Control and Prevention, Anhui Hefei 230601, ChinaBeijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention, Beijing 100013, ChinaThe current study, using a systematic-literature-search approach, was intended to conduct hazard identification for dehydroacetic acid (DHA) and sodium dehydroacetate (DHA-S) which are currently used as food additives in China. DHA and DHA-S belong to the category of low toxic chemicals in terms of acute toxicity, mainly causing adverse effects in the central nervous system. Its subacute, subchronic and chronic toxicity mainly include significant reduction of body weight and food intake as well as anticoagulant effect. Reproductive development toxicity result show they can decrease body weight and inhibit bone development in offspring. According to the hazard identification result, oral intake of dehydroacetic acid and its sodium salt can produce a variety of toxic effects above certain doses. Further study is needed to determine the acceptable daily intake of DHA and its sodium salt and provide scientific evidence for safely use of these compounds as food additives.http://www.zgspws.com/zgspwszzen/article/abstract/20200522food additivedehydroacetic acidsodium dehydroacetatetoxicityhazard identification |
| spellingShingle | Xiao XIAO Guojun LI Yan SONG Zhou YU Jian JIANG Hongju DU Hazard identification of dehydroacetic acid and its sodium salt used as food additives based on systematic literature searches Zhongguo shipin weisheng zazhi food additive dehydroacetic acid sodium dehydroacetate toxicity hazard identification |
| title | Hazard identification of dehydroacetic acid and its sodium salt used as food additives based on systematic literature searches |
| title_full | Hazard identification of dehydroacetic acid and its sodium salt used as food additives based on systematic literature searches |
| title_fullStr | Hazard identification of dehydroacetic acid and its sodium salt used as food additives based on systematic literature searches |
| title_full_unstemmed | Hazard identification of dehydroacetic acid and its sodium salt used as food additives based on systematic literature searches |
| title_short | Hazard identification of dehydroacetic acid and its sodium salt used as food additives based on systematic literature searches |
| title_sort | hazard identification of dehydroacetic acid and its sodium salt used as food additives based on systematic literature searches |
| topic | food additive dehydroacetic acid sodium dehydroacetate toxicity hazard identification |
| url | http://www.zgspws.com/zgspwszzen/article/abstract/20200522 |
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