Everything You Always Wanted to Know about β<sub>3</sub>-AR * (* But Were Afraid to Ask)
The beta-3 adrenergic receptor (β<sub>3</sub>-AR) is by far the least studied isotype of the beta-adrenergic sub-family. Despite its study being long hampered by the lack of suitable animal and cellular models and inter-species differences, a substantial body of literature on th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/4/357 |
| _version_ | 1797705735399800832 |
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| author | Giorgia Schena Michael J. Caplan |
| author_facet | Giorgia Schena Michael J. Caplan |
| author_sort | Giorgia Schena |
| collection | DOAJ |
| description | The beta-3 adrenergic receptor (β<sub>3</sub>-AR) is by far the least studied isotype of the beta-adrenergic sub-family. Despite its study being long hampered by the lack of suitable animal and cellular models and inter-species differences, a substantial body of literature on the subject has built up in the last three decades and the physiology of β<sub>3</sub>-AR is unraveling quickly. As will become evident in this work, β<sub>3</sub>-AR is emerging as an appealing target for novel pharmacological approaches in several clinical areas involving metabolic, cardiovascular, urinary, and ocular disease. In this review, we will discuss the most recent advances regarding β<sub>3</sub>-AR signaling and function and summarize how these findings translate, or may do so, into current clinical practice highlighting β<sub>3</sub>-AR’s great potential as a novel therapeutic target in a wide range of human conditions. |
| first_indexed | 2024-03-12T05:41:49Z |
| format | Article |
| id | doaj.art-ac4a79aeaa7a418a95197a09ef5d49ad |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T05:41:49Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-ac4a79aeaa7a418a95197a09ef5d49ad2023-09-03T06:01:11ZengMDPI AGCells2073-44092019-04-018435710.3390/cells8040357cells8040357Everything You Always Wanted to Know about β<sub>3</sub>-AR * (* But Were Afraid to Ask)Giorgia Schena0Michael J. Caplan1Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USADepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USAThe beta-3 adrenergic receptor (β<sub>3</sub>-AR) is by far the least studied isotype of the beta-adrenergic sub-family. Despite its study being long hampered by the lack of suitable animal and cellular models and inter-species differences, a substantial body of literature on the subject has built up in the last three decades and the physiology of β<sub>3</sub>-AR is unraveling quickly. As will become evident in this work, β<sub>3</sub>-AR is emerging as an appealing target for novel pharmacological approaches in several clinical areas involving metabolic, cardiovascular, urinary, and ocular disease. In this review, we will discuss the most recent advances regarding β<sub>3</sub>-AR signaling and function and summarize how these findings translate, or may do so, into current clinical practice highlighting β<sub>3</sub>-AR’s great potential as a novel therapeutic target in a wide range of human conditions.https://www.mdpi.com/2073-4409/8/4/357beta-3 adrenergic receptortherapeutic targetG-protein coupled receptors |
| spellingShingle | Giorgia Schena Michael J. Caplan Everything You Always Wanted to Know about β<sub>3</sub>-AR * (* But Were Afraid to Ask) Cells beta-3 adrenergic receptor therapeutic target G-protein coupled receptors |
| title | Everything You Always Wanted to Know about β<sub>3</sub>-AR * (* But Were Afraid to Ask) |
| title_full | Everything You Always Wanted to Know about β<sub>3</sub>-AR * (* But Were Afraid to Ask) |
| title_fullStr | Everything You Always Wanted to Know about β<sub>3</sub>-AR * (* But Were Afraid to Ask) |
| title_full_unstemmed | Everything You Always Wanted to Know about β<sub>3</sub>-AR * (* But Were Afraid to Ask) |
| title_short | Everything You Always Wanted to Know about β<sub>3</sub>-AR * (* But Were Afraid to Ask) |
| title_sort | everything you always wanted to know about β sub 3 sub ar but were afraid to ask |
| topic | beta-3 adrenergic receptor therapeutic target G-protein coupled receptors |
| url | https://www.mdpi.com/2073-4409/8/4/357 |
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