The metabolic syndrome and renal function in an African cohort infected with human immunodeficiency virus
Introduction: The human immunodeficiency virus (HIV) is often accompanied by renal dysfunction. It is expected that metabolic syndrome (MetS) may exacerbate renal impairment. Objective: We therefore determined the prevalence of MetS and the association thereof with renal function in a South African...
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| Format: | Article |
| Language: | English |
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AOSIS
2018-09-01
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| Series: | Southern African Journal of HIV Medicine |
| Subjects: | |
| Online Access: | https://sajhivmed.org.za/index.php/hivmed/article/view/813 |
| _version_ | 1811302699653660672 |
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| author | Edith Phalane Carla M.T. Fourie Aletta E. Schutte |
| author_facet | Edith Phalane Carla M.T. Fourie Aletta E. Schutte |
| author_sort | Edith Phalane |
| collection | DOAJ |
| description | Introduction: The human immunodeficiency virus (HIV) is often accompanied by renal dysfunction. It is expected that metabolic syndrome (MetS) may exacerbate renal impairment.
Objective: We therefore determined the prevalence of MetS and the association thereof with renal function in a South African cohort infected with HIV.
Methods: We matched 114 HIV-infected (77.3% on antiretroviral therapy [ART] and 22.7% ART-naïve) and 114 HIV-uninfected individuals according to age, sex and locality. We examined cardiovascular, anthropometric and metabolic measurements and determined the MetS. Renal function was assessed using standardised procedures.
Results: The prevalence of MetS was lower in the HIV-infected individuals as compared to the uninfected individuals (28% vs. 44%, p = 0.013). The HIV-infected group presented with a lower body mass index (BMI) and waist circumference (WC) (all p < 0.001), as well as blood pressure (BP) (p ≤ 0.0021). The results were confirmed when comparing the HIV-infected group using ART (N = 85) and the HIV-uninfected group. When comparing the HIV-infected individuals with MetS to the HIV-uninfected individuals with MetS, no differences in BP were seen. With regard to renal function, the HIV-infected individuals with MetS (n = 32) had 43% higher urinary albumin-creatinine ratio (uACR) compared to the HIV-uninfected individuals with MetS, after adjusting for age, sex and WC (p = 0.032). None of the other renal function markers differed after adjustments for WC or BMI.
Conclusion: The HIV-infected Africans with MetS had almost twofold higher uACR, despite the low prevalence of MetS, compared to their uninfected counterparts. The combination of HIV and MetS seemed to increase the risk for renal impairment. |
| first_indexed | 2024-04-13T07:33:50Z |
| format | Article |
| id | doaj.art-ac4c6d9d893a4254882057f911b1ddba |
| institution | Directory Open Access Journal |
| issn | 1608-9693 2078-6751 |
| language | English |
| last_indexed | 2024-04-13T07:33:50Z |
| publishDate | 2018-09-01 |
| publisher | AOSIS |
| record_format | Article |
| series | Southern African Journal of HIV Medicine |
| spelling | doaj.art-ac4c6d9d893a4254882057f911b1ddba2022-12-22T02:56:15ZengAOSISSouthern African Journal of HIV Medicine1608-96932078-67512018-09-01191e1e1010.4102/sajhivmed.v19i1.813596The metabolic syndrome and renal function in an African cohort infected with human immunodeficiency virusEdith Phalane0Carla M.T. Fourie1Aletta E. Schutte2Hypertension in Africa Research Team, North-West UniversityHypertension in Africa Research Team, North-West University, South Africa; and, Medical Research Council Unit for Hypertension and Cardiovascular Disease, Faculty of Health Sciences, North-West UniversityHypertension in Africa Research Team, North-West University, South Africa; and, Medical Research Council Unit for Hypertension and Cardiovascular Disease, Faculty of Health Sciences, North-West UniversityIntroduction: The human immunodeficiency virus (HIV) is often accompanied by renal dysfunction. It is expected that metabolic syndrome (MetS) may exacerbate renal impairment. Objective: We therefore determined the prevalence of MetS and the association thereof with renal function in a South African cohort infected with HIV. Methods: We matched 114 HIV-infected (77.3% on antiretroviral therapy [ART] and 22.7% ART-naïve) and 114 HIV-uninfected individuals according to age, sex and locality. We examined cardiovascular, anthropometric and metabolic measurements and determined the MetS. Renal function was assessed using standardised procedures. Results: The prevalence of MetS was lower in the HIV-infected individuals as compared to the uninfected individuals (28% vs. 44%, p = 0.013). The HIV-infected group presented with a lower body mass index (BMI) and waist circumference (WC) (all p < 0.001), as well as blood pressure (BP) (p ≤ 0.0021). The results were confirmed when comparing the HIV-infected group using ART (N = 85) and the HIV-uninfected group. When comparing the HIV-infected individuals with MetS to the HIV-uninfected individuals with MetS, no differences in BP were seen. With regard to renal function, the HIV-infected individuals with MetS (n = 32) had 43% higher urinary albumin-creatinine ratio (uACR) compared to the HIV-uninfected individuals with MetS, after adjusting for age, sex and WC (p = 0.032). None of the other renal function markers differed after adjustments for WC or BMI. Conclusion: The HIV-infected Africans with MetS had almost twofold higher uACR, despite the low prevalence of MetS, compared to their uninfected counterparts. The combination of HIV and MetS seemed to increase the risk for renal impairment.https://sajhivmed.org.za/index.php/hivmed/article/view/813cardio-metabolic diseasesHIV |
| spellingShingle | Edith Phalane Carla M.T. Fourie Aletta E. Schutte The metabolic syndrome and renal function in an African cohort infected with human immunodeficiency virus Southern African Journal of HIV Medicine cardio-metabolic diseases HIV |
| title | The metabolic syndrome and renal function in an African cohort infected with human immunodeficiency virus |
| title_full | The metabolic syndrome and renal function in an African cohort infected with human immunodeficiency virus |
| title_fullStr | The metabolic syndrome and renal function in an African cohort infected with human immunodeficiency virus |
| title_full_unstemmed | The metabolic syndrome and renal function in an African cohort infected with human immunodeficiency virus |
| title_short | The metabolic syndrome and renal function in an African cohort infected with human immunodeficiency virus |
| title_sort | metabolic syndrome and renal function in an african cohort infected with human immunodeficiency virus |
| topic | cardio-metabolic diseases HIV |
| url | https://sajhivmed.org.za/index.php/hivmed/article/view/813 |
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