Ribosome Rescue Pathways in Bacteria
Ribosomes that become stalled on truncated or damaged mRNAs during protein synthesis must be rescued for the cell to survive. Bacteria have evolved a diverse array of rescue pathways to remove the stalled ribosomes from the aberrant mRNA and return them to the free pool of actively translating ribos...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.652980/full |
| _version_ | 1818914597253414912 |
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| author | Claudia Müller Caillan Crowe-McAuliffe Daniel N. Wilson |
| author_facet | Claudia Müller Caillan Crowe-McAuliffe Daniel N. Wilson |
| author_sort | Claudia Müller |
| collection | DOAJ |
| description | Ribosomes that become stalled on truncated or damaged mRNAs during protein synthesis must be rescued for the cell to survive. Bacteria have evolved a diverse array of rescue pathways to remove the stalled ribosomes from the aberrant mRNA and return them to the free pool of actively translating ribosomes. In addition, some of these pathways target the damaged mRNA and the incomplete nascent polypeptide chain for degradation. This review highlights the recent developments in our mechanistic understanding of bacterial ribosomal rescue systems, including drop-off, trans-translation mediated by transfer-messenger RNA and small protein B, ribosome rescue by the alternative rescue factors ArfA and ArfB, as well as Bacillus ribosome rescue factor A, an additional rescue system found in some Gram-positive bacteria, such as Bacillus subtilis. Finally, we discuss the recent findings of ribosome-associated quality control in particular bacterial lineages mediated by RqcH and RqcP. The importance of rescue pathways for bacterial survival suggests they may represent novel targets for the development of new antimicrobial agents against multi-drug resistant pathogenic bacteria. |
| first_indexed | 2024-12-19T23:48:55Z |
| format | Article |
| id | doaj.art-ac4cd9f665cd4d58af16020c08a86175 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-19T23:48:55Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-ac4cd9f665cd4d58af16020c08a861752022-12-21T20:01:14ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-03-011210.3389/fmicb.2021.652980652980Ribosome Rescue Pathways in BacteriaClaudia MüllerCaillan Crowe-McAuliffeDaniel N. WilsonRibosomes that become stalled on truncated or damaged mRNAs during protein synthesis must be rescued for the cell to survive. Bacteria have evolved a diverse array of rescue pathways to remove the stalled ribosomes from the aberrant mRNA and return them to the free pool of actively translating ribosomes. In addition, some of these pathways target the damaged mRNA and the incomplete nascent polypeptide chain for degradation. This review highlights the recent developments in our mechanistic understanding of bacterial ribosomal rescue systems, including drop-off, trans-translation mediated by transfer-messenger RNA and small protein B, ribosome rescue by the alternative rescue factors ArfA and ArfB, as well as Bacillus ribosome rescue factor A, an additional rescue system found in some Gram-positive bacteria, such as Bacillus subtilis. Finally, we discuss the recent findings of ribosome-associated quality control in particular bacterial lineages mediated by RqcH and RqcP. The importance of rescue pathways for bacterial survival suggests they may represent novel targets for the development of new antimicrobial agents against multi-drug resistant pathogenic bacteria.https://www.frontiersin.org/articles/10.3389/fmicb.2021.652980/fullArfAArfBribosome rescueribosome-associated quality controlRqcHtmRNA |
| spellingShingle | Claudia Müller Caillan Crowe-McAuliffe Daniel N. Wilson Ribosome Rescue Pathways in Bacteria Frontiers in Microbiology ArfA ArfB ribosome rescue ribosome-associated quality control RqcH tmRNA |
| title | Ribosome Rescue Pathways in Bacteria |
| title_full | Ribosome Rescue Pathways in Bacteria |
| title_fullStr | Ribosome Rescue Pathways in Bacteria |
| title_full_unstemmed | Ribosome Rescue Pathways in Bacteria |
| title_short | Ribosome Rescue Pathways in Bacteria |
| title_sort | ribosome rescue pathways in bacteria |
| topic | ArfA ArfB ribosome rescue ribosome-associated quality control RqcH tmRNA |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.652980/full |
| work_keys_str_mv | AT claudiamuller ribosomerescuepathwaysinbacteria AT caillancrowemcauliffe ribosomerescuepathwaysinbacteria AT danielnwilson ribosomerescuepathwaysinbacteria |