Dock10 Regulates Cardiac Function under Neurohormonal Stress

Dock10 Regulates Cardiac Function under Neurohormonal Stress

Dedicator of cytokinesis 10 (Dock10) is a guanine nucleotide exchange factor for Cdc42 and Rac1 that regulates the JNK (c-Jun N-terminal kinase) and p38 MAPK (mitogen-activated protein kinase) signaling cascades. In this study, we characterized the roles of Dock10 in the myocardium. In vitro: we abl...

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Bibliographic Details
Main Authors: Liad Segal, Sharon Etzion, Sigal Elyagon, Moran Shahar, Hadar Klapper-Goldstein, Aviva Levitas, Michael S. Kapiloff, Ruti Parvari, Yoram Etzion
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
Rho GTPases
Cdc42
Rac1
MAPK signaling
pathological cardiac hypertrophy
Online Access:https://www.mdpi.com/1422-0067/23/17/9616

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