A 28-Day Toxicity Study of Tenofovir Alafenamide Hemifumarate by Subcutaneous Infusion in Rats and Dogs

A 28-Day Toxicity Study of Tenofovir Alafenamide Hemifumarate by Subcutaneous Infusion in Rats and Dogs

ABSTRACT The toxicity of tenofovir alafenamide (TAF) hemifumarate (HF) was evaluated when administered by continuous subcutaneous (s.c.) infusion via an external infusion pump for 28 days to rats and dogs. The toxicokinetics of TAF and two metabolites, tenofovir (TFV) and tenofovir diphosphate (TFV-...

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Bibliographic Details
Main Authors: Doris Zane, Shane Roller, Josephine Shelton, Roshni Singh, Rachna Jain, Yan Wang, Bing Yang, Melanie Felx, Thomas Alessi, Paul L. Feldman
Format: Article
Language:English
Published: American Society for Microbiology 2021-09-01
Series:Microbiology Spectrum
Subjects:
tenofovir alafenamide
subcutaneous
human immunodeficiency virus
antiretroviral
preexposure prophylaxis
Online Access:https://journals.asm.org/doi/10.1128/Spectrum.00339-21

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