Involvement of Nrf2, JAK and COX pathways in acetaminophen-induced nephropathy: Role of some antioxidants

Involvement of Nrf2, JAK and COX pathways in acetaminophen-induced nephropathy: Role of some antioxidants

Objectives: Acetaminophen (APAP)-induced nephrotoxicity is detrimental consequence for which there has not been a standardized therapeutic regimen. Although, N-acetylcysteine (NAC) is a well-known antidote used in APAP-induced hepatotoxicity, its benefit in nephrotoxicity caused by APAP is almost la...

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Bibliographic Details
Main Authors: Qamraa H. Alqahtani, Laila M. Fadda, Ahlam M. Alhusaini, Iman H. Hasan, Hanaa M. Ali
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Saudi Pharmaceutical Journal
Subjects:
Acetaminophen
Thymoquinone
Curcumin
N-acetylcysteine
α-Lipoic acid
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016423002475

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