Corneal Permeability and Uptake of Twenty-Five Drugs: Species Comparison and Quantitative Structure–Permeability Relationships

Corneal Permeability and Uptake of Twenty-Five Drugs: Species Comparison and Quantitative Structure–Permeability Relationships

The purpose of this study was to determine corneal permeability and uptake in rabbit, porcine, and bovine corneas for twenty-five drugs using an N-in-1 (cassette) approach and relate these parameters to drug physicochemical properties and tissue thickness through quantitative structure permeability...

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Bibliographic Details
Main Authors: Cleildo P. Santana, Brock A. Matter, Madhoosudan A. Patil, Armando Silva-Cunha, Uday B. Kompella
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Pharmaceutics
Subjects:
β-blockers
NSAIDs
corticosteroids
drug delivery
ocular delivery
drug permeability
Online Access:https://www.mdpi.com/1999-4923/15/6/1646

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