Correlation of serum IL-2 and IFN-γ levels with clinical prognosis of nasopharyngeal carcinoma patients and analysis of risk factors
Background: This study aims to investigate the correlation between serum levels of interleukin-2 (IL-2) and interferong (IFN-g) and the clinical prognosis of patients with nasopharyngeal carcinoma (NPC). Additionally, the study aims to analyse the risk factors associated with this correlation. Metho...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2024-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2024/1452-82582401050G.pdf |
| _version_ | 1797319639172120576 |
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| author | Guo Siquan Qin Feng Wang Jiang Ding Yongqing You Jianqiang Chao Changjiang |
| author_facet | Guo Siquan Qin Feng Wang Jiang Ding Yongqing You Jianqiang Chao Changjiang |
| author_sort | Guo Siquan |
| collection | DOAJ |
| description | Background: This study aims to investigate the correlation between serum levels of interleukin-2 (IL-2) and interferong (IFN-g) and the clinical prognosis of patients with nasopharyngeal carcinoma (NPC). Additionally, the study aims to analyse the risk factors associated with this correlation. Methods: The clinical data of 195 NPC patients admitted to our hospital from October 2020 to October 2022 were selected for a retrospective study. Based on the Glasgow score, patients were divided into two groups: the good prognosis group (group g), consisting of patients who scored 0 points, and the poor prognosis group (group p), consisting of patients who scored 1-2 points. The levels of serum IL-2 and IFN-g were compared between the two groups, and the clinical values of serum IL-2 and IFN-g in the prognosis of patients were analysed. The clinical parameters of the patients were collected, and the risk factors affecting the prognosis of NPC were analysed by univariate and multivariate logistic regression. Results: Among 195 patients, 125 were in group g, and 70 were in group p. The levels of IL-2 and IFN-g in group g were higher than in group p (P<0.05). The predictive AUC (95%CI) of IL-2 and IFN-g were 0.846 (0.791-0.902) and 0.851 (0.797-0.904), respectively (P<0.05). Logistic regression analysis showed that age, tumour diameter, clinical stages and degree of differentiation were risk factors for the prognosis of NPC patients. Conclusion: The levels of serum IL-2 and IFN-g are closely related to the prognosis of NPC patients and have certain value in evaluating the prognosis of patients. The age, tumour diameter, tumour staging and degree of tumour differentiation are all risk factors affecting the prognosis of patients, which can provide a reference for selecting clinical treatment methods and evaluating prognosis. |
| first_indexed | 2024-03-08T04:10:47Z |
| format | Article |
| id | doaj.art-ac5378d0c3cd43c9a53f8563380b9d9e |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-03-08T04:10:47Z |
| publishDate | 2024-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-ac5378d0c3cd43c9a53f8563380b9d9e2024-02-08T22:37:02ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662024-01-01431505610.5937/jomb0-440571452-82582401050GCorrelation of serum IL-2 and IFN-γ levels with clinical prognosis of nasopharyngeal carcinoma patients and analysis of risk factorsGuo Siquan0Qin Feng1Wang Jiang2Ding Yongqing3You Jianqiang4Chao Changjiang5Third Affiliated Hospital of Soochow University, Department of Otorhinolaryngology Head and Neck Surgery, Changzhou, ChinaNanjing Medical University, Changzhou Third People's Hospital, Changzhou Medical Center, Department of Otorhinolaryngology Head and Neck Surgery, Changzhou, ChinaThird Affiliated Hospital of Soochow University, Department of Otorhinolaryngology Head and Neck Surgery, Changzhou, ChinaFirst Affiliated Hospital of Hebei North University, Department of Otorhinolaryngology Head and Neck Surgery, Zhangjiakou, ChinaThird Affiliated Hospital of Soochow University, Department of Otorhinolaryngology Head and Neck Surgery, Changzhou, ChinaThird Affiliated Hospital of Soochow University, Department of Otorhinolaryngology Head and Neck Surgery, Changzhou, ChinaBackground: This study aims to investigate the correlation between serum levels of interleukin-2 (IL-2) and interferong (IFN-g) and the clinical prognosis of patients with nasopharyngeal carcinoma (NPC). Additionally, the study aims to analyse the risk factors associated with this correlation. Methods: The clinical data of 195 NPC patients admitted to our hospital from October 2020 to October 2022 were selected for a retrospective study. Based on the Glasgow score, patients were divided into two groups: the good prognosis group (group g), consisting of patients who scored 0 points, and the poor prognosis group (group p), consisting of patients who scored 1-2 points. The levels of serum IL-2 and IFN-g were compared between the two groups, and the clinical values of serum IL-2 and IFN-g in the prognosis of patients were analysed. The clinical parameters of the patients were collected, and the risk factors affecting the prognosis of NPC were analysed by univariate and multivariate logistic regression. Results: Among 195 patients, 125 were in group g, and 70 were in group p. The levels of IL-2 and IFN-g in group g were higher than in group p (P<0.05). The predictive AUC (95%CI) of IL-2 and IFN-g were 0.846 (0.791-0.902) and 0.851 (0.797-0.904), respectively (P<0.05). Logistic regression analysis showed that age, tumour diameter, clinical stages and degree of differentiation were risk factors for the prognosis of NPC patients. Conclusion: The levels of serum IL-2 and IFN-g are closely related to the prognosis of NPC patients and have certain value in evaluating the prognosis of patients. The age, tumour diameter, tumour staging and degree of tumour differentiation are all risk factors affecting the prognosis of patients, which can provide a reference for selecting clinical treatment methods and evaluating prognosis.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2024/1452-82582401050G.pdfil-2ifn-γnasopharyngeal carcinomacorrelationrisk factors |
| spellingShingle | Guo Siquan Qin Feng Wang Jiang Ding Yongqing You Jianqiang Chao Changjiang Correlation of serum IL-2 and IFN-γ levels with clinical prognosis of nasopharyngeal carcinoma patients and analysis of risk factors Journal of Medical Biochemistry il-2 ifn-γ nasopharyngeal carcinoma correlation risk factors |
| title | Correlation of serum IL-2 and IFN-γ levels with clinical prognosis of nasopharyngeal carcinoma patients and analysis of risk factors |
| title_full | Correlation of serum IL-2 and IFN-γ levels with clinical prognosis of nasopharyngeal carcinoma patients and analysis of risk factors |
| title_fullStr | Correlation of serum IL-2 and IFN-γ levels with clinical prognosis of nasopharyngeal carcinoma patients and analysis of risk factors |
| title_full_unstemmed | Correlation of serum IL-2 and IFN-γ levels with clinical prognosis of nasopharyngeal carcinoma patients and analysis of risk factors |
| title_short | Correlation of serum IL-2 and IFN-γ levels with clinical prognosis of nasopharyngeal carcinoma patients and analysis of risk factors |
| title_sort | correlation of serum il 2 and ifn γ levels with clinical prognosis of nasopharyngeal carcinoma patients and analysis of risk factors |
| topic | il-2 ifn-γ nasopharyngeal carcinoma correlation risk factors |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2024/1452-82582401050G.pdf |
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