Detrimental effects of environmental tobacco smoke in relation to asthma severity.
<h4>Background</h4>Environmental tobacco smoke (ETS) has adverse effects on the health of asthmatics, however the harmful consequences of ETS in relation to asthma severity are unknown.<h4>Methods</h4>In a multicenter study of severe asthma, we assessed the impact of ETS expo...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-05-01
|
| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21572527/pdf/?tool=EBI |
| _version_ | 1818845198577303552 |
|---|---|
| author | Suzy A A Comhair Benjamin M Gaston Kristin S Ricci Jeffrey Hammel Raed A Dweik W Gerald Teague Deborah Meyers Elizabeth J Ampleford Eugene R Bleecker William W Busse William J Calhoun Mario Castro Kian Fan Chung Douglas Curran-Everett Elliot Israel W Nizar Jarjour Wendy Moore Stephen P Peters Sally Wenzel Stanley L Hazen Serpil C Erzurum National Heart Lung Blood Institute Severe Asthma Research Program |
| author_facet | Suzy A A Comhair Benjamin M Gaston Kristin S Ricci Jeffrey Hammel Raed A Dweik W Gerald Teague Deborah Meyers Elizabeth J Ampleford Eugene R Bleecker William W Busse William J Calhoun Mario Castro Kian Fan Chung Douglas Curran-Everett Elliot Israel W Nizar Jarjour Wendy Moore Stephen P Peters Sally Wenzel Stanley L Hazen Serpil C Erzurum National Heart Lung Blood Institute Severe Asthma Research Program |
| author_sort | Suzy A A Comhair |
| collection | DOAJ |
| description | <h4>Background</h4>Environmental tobacco smoke (ETS) has adverse effects on the health of asthmatics, however the harmful consequences of ETS in relation to asthma severity are unknown.<h4>Methods</h4>In a multicenter study of severe asthma, we assessed the impact of ETS exposure on morbidity, health care utilization and lung functions; and activity of systemic superoxide dismutase (SOD), a potential oxidative target of ETS that is negatively associated with asthma severity.<h4>Findings</h4>From 2002-2006, 654 asthmatics (non-severe 366, severe 288) were enrolled, among whom 109 non-severe and 67 severe asthmatics were routinely exposed to ETS as ascertained by history and validated by urine cotinine levels. ETS-exposure was associated with lower quality of life scores; greater rescue inhaler use; lower lung function; greater bronchodilator responsiveness; and greater risk for emergency room visits, hospitalization and intensive care unit admission. ETS-exposure was associated with lower levels of serum SOD activity, particularly in asthmatic women of African heritage.<h4>Interpretation</h4>ETS-exposure of asthmatic individuals is associated with worse lung function, higher acuity of exacerbations, more health care utilization, and greater bronchial hyperreactivity. The association of diminished systemic SOD activity to ETS exposure provides for the first time a specific oxidant mechanism by which ETS may adversely affect patients with asthma. |
| first_indexed | 2024-12-19T05:25:51Z |
| format | Article |
| id | doaj.art-ac56f67e825440789a6b0452b5a9ec80 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T05:25:51Z |
| publishDate | 2011-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ac56f67e825440789a6b0452b5a9ec802022-12-21T20:34:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-05-0165e1857410.1371/journal.pone.0018574Detrimental effects of environmental tobacco smoke in relation to asthma severity.Suzy A A ComhairBenjamin M GastonKristin S RicciJeffrey HammelRaed A DweikW Gerald TeagueDeborah MeyersElizabeth J AmplefordEugene R BleeckerWilliam W BusseWilliam J CalhounMario CastroKian Fan ChungDouglas Curran-EverettElliot IsraelW Nizar JarjourWendy MooreStephen P PetersSally WenzelStanley L HazenSerpil C ErzurumNational Heart Lung Blood Institute Severe Asthma Research Program<h4>Background</h4>Environmental tobacco smoke (ETS) has adverse effects on the health of asthmatics, however the harmful consequences of ETS in relation to asthma severity are unknown.<h4>Methods</h4>In a multicenter study of severe asthma, we assessed the impact of ETS exposure on morbidity, health care utilization and lung functions; and activity of systemic superoxide dismutase (SOD), a potential oxidative target of ETS that is negatively associated with asthma severity.<h4>Findings</h4>From 2002-2006, 654 asthmatics (non-severe 366, severe 288) were enrolled, among whom 109 non-severe and 67 severe asthmatics were routinely exposed to ETS as ascertained by history and validated by urine cotinine levels. ETS-exposure was associated with lower quality of life scores; greater rescue inhaler use; lower lung function; greater bronchodilator responsiveness; and greater risk for emergency room visits, hospitalization and intensive care unit admission. ETS-exposure was associated with lower levels of serum SOD activity, particularly in asthmatic women of African heritage.<h4>Interpretation</h4>ETS-exposure of asthmatic individuals is associated with worse lung function, higher acuity of exacerbations, more health care utilization, and greater bronchial hyperreactivity. The association of diminished systemic SOD activity to ETS exposure provides for the first time a specific oxidant mechanism by which ETS may adversely affect patients with asthma.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21572527/pdf/?tool=EBI |
| spellingShingle | Suzy A A Comhair Benjamin M Gaston Kristin S Ricci Jeffrey Hammel Raed A Dweik W Gerald Teague Deborah Meyers Elizabeth J Ampleford Eugene R Bleecker William W Busse William J Calhoun Mario Castro Kian Fan Chung Douglas Curran-Everett Elliot Israel W Nizar Jarjour Wendy Moore Stephen P Peters Sally Wenzel Stanley L Hazen Serpil C Erzurum National Heart Lung Blood Institute Severe Asthma Research Program Detrimental effects of environmental tobacco smoke in relation to asthma severity. PLoS ONE |
| title | Detrimental effects of environmental tobacco smoke in relation to asthma severity. |
| title_full | Detrimental effects of environmental tobacco smoke in relation to asthma severity. |
| title_fullStr | Detrimental effects of environmental tobacco smoke in relation to asthma severity. |
| title_full_unstemmed | Detrimental effects of environmental tobacco smoke in relation to asthma severity. |
| title_short | Detrimental effects of environmental tobacco smoke in relation to asthma severity. |
| title_sort | detrimental effects of environmental tobacco smoke in relation to asthma severity |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21572527/pdf/?tool=EBI |
| work_keys_str_mv | AT suzyaacomhair detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT benjaminmgaston detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT kristinsricci detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT jeffreyhammel detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT raedadweik detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT wgeraldteague detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT deborahmeyers detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT elizabethjampleford detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT eugenerbleecker detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT williamwbusse detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT williamjcalhoun detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT mariocastro detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT kianfanchung detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT douglascurraneverett detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT elliotisrael detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT wnizarjarjour detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT wendymoore detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT stephenppeters detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT sallywenzel detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT stanleylhazen detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT serpilcerzurum detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity AT nationalheartlungbloodinstitutesevereasthmaresearchprogram detrimentaleffectsofenvironmentaltobaccosmokeinrelationtoasthmaseverity |