A Mechanistic Overview on Impact of Dietary Fibres on Gut Microbiota and Its Association with Colon Cancer
Colorectal cancer (CRC) is an abnormal growth that occurs in the rectum or rectal portion. In 2020, an anticipated 104,610 new cases of colon illness and 43,340 new cases of rectal abnormal growth were expected in the United States. Red and processed meat, body bloatedness, belly fatness, and binge...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Dietetics |
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| Online Access: | https://www.mdpi.com/2674-0311/1/3/17 |
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| author | Vasudev Biswas Asma Praveen Arya Lakshmi Marisetti Ajay Sharma Vijender Kumar Sanjeev Kumar Sahu Devesh Tewari |
| author_facet | Vasudev Biswas Asma Praveen Arya Lakshmi Marisetti Ajay Sharma Vijender Kumar Sanjeev Kumar Sahu Devesh Tewari |
| author_sort | Vasudev Biswas |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is an abnormal growth that occurs in the rectum or rectal portion. In 2020, an anticipated 104,610 new cases of colon illness and 43,340 new cases of rectal abnormal growth were expected in the United States. Red and processed meat, body bloatedness, belly fatness, and binge drinking expands the occurrence of colorectal disease. Dietary fibres contribute to faecal bulking, but they are break down by gut bacteria and produce metabolites such as short-chain fatty acids (SCFAs). SCFAs are chemical compounds that are mostly made up of acetate, propionate, and butyrate. Acetate and butyrate help to control mucus production and discharge, and thus, protect the gut mucosa. Reduced mucus secretion/increased bacterial catabolism, and fermentation of amino acids resulted in an increase of potentially detrimental metabolites such as branched-chain fatty acids, ammonia, amines, and N-nitroso complex components. Vital roles of fibres include reduction in the time that carcinogens encounter the intestinal lumen and promotion of healthy gut microbiota as well as modification of the host metabolism. The present review focuses on a brief introduction to various dietary fibres and specialised metabolites that can possess beneficial effect on CRC, as well as presenting our current, detailed understanding of various dietary fibres along with their potential effects on gut microbiota and its association with the colon cancer. A comprehensive discussion is also included, advocating the dietary fibre-enriched diet. |
| first_indexed | 2024-03-11T07:27:52Z |
| format | Article |
| id | doaj.art-ac5848228d0e4ed19bfb91f740e1d09a |
| institution | Directory Open Access Journal |
| issn | 2674-0311 |
| language | English |
| last_indexed | 2024-03-11T07:27:52Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dietetics |
| spelling | doaj.art-ac5848228d0e4ed19bfb91f740e1d09a2023-11-17T07:31:11ZengMDPI AGDietetics2674-03112022-11-011318220210.3390/dietetics1030017A Mechanistic Overview on Impact of Dietary Fibres on Gut Microbiota and Its Association with Colon CancerVasudev Biswas0Asma Praveen1Arya Lakshmi Marisetti2Ajay Sharma3Vijender Kumar4Sanjeev Kumar Sahu5Devesh Tewari6Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, IndiaDepartment of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, IndiaDepartment of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, IndiaDepartment of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, IndiaDepartment of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, IndiaSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, IndiaDepartment of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, IndiaColorectal cancer (CRC) is an abnormal growth that occurs in the rectum or rectal portion. In 2020, an anticipated 104,610 new cases of colon illness and 43,340 new cases of rectal abnormal growth were expected in the United States. Red and processed meat, body bloatedness, belly fatness, and binge drinking expands the occurrence of colorectal disease. Dietary fibres contribute to faecal bulking, but they are break down by gut bacteria and produce metabolites such as short-chain fatty acids (SCFAs). SCFAs are chemical compounds that are mostly made up of acetate, propionate, and butyrate. Acetate and butyrate help to control mucus production and discharge, and thus, protect the gut mucosa. Reduced mucus secretion/increased bacterial catabolism, and fermentation of amino acids resulted in an increase of potentially detrimental metabolites such as branched-chain fatty acids, ammonia, amines, and N-nitroso complex components. Vital roles of fibres include reduction in the time that carcinogens encounter the intestinal lumen and promotion of healthy gut microbiota as well as modification of the host metabolism. The present review focuses on a brief introduction to various dietary fibres and specialised metabolites that can possess beneficial effect on CRC, as well as presenting our current, detailed understanding of various dietary fibres along with their potential effects on gut microbiota and its association with the colon cancer. A comprehensive discussion is also included, advocating the dietary fibre-enriched diet.https://www.mdpi.com/2674-0311/1/3/17carbohydratescolorectal cancerdietflavonoidsprobioticsSCFA |
| spellingShingle | Vasudev Biswas Asma Praveen Arya Lakshmi Marisetti Ajay Sharma Vijender Kumar Sanjeev Kumar Sahu Devesh Tewari A Mechanistic Overview on Impact of Dietary Fibres on Gut Microbiota and Its Association with Colon Cancer Dietetics carbohydrates colorectal cancer diet flavonoids probiotics SCFA |
| title | A Mechanistic Overview on Impact of Dietary Fibres on Gut Microbiota and Its Association with Colon Cancer |
| title_full | A Mechanistic Overview on Impact of Dietary Fibres on Gut Microbiota and Its Association with Colon Cancer |
| title_fullStr | A Mechanistic Overview on Impact of Dietary Fibres on Gut Microbiota and Its Association with Colon Cancer |
| title_full_unstemmed | A Mechanistic Overview on Impact of Dietary Fibres on Gut Microbiota and Its Association with Colon Cancer |
| title_short | A Mechanistic Overview on Impact of Dietary Fibres on Gut Microbiota and Its Association with Colon Cancer |
| title_sort | mechanistic overview on impact of dietary fibres on gut microbiota and its association with colon cancer |
| topic | carbohydrates colorectal cancer diet flavonoids probiotics SCFA |
| url | https://www.mdpi.com/2674-0311/1/3/17 |
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