Role of mitochondria in brain functions and related disorders
Mitochondria are important organelles for high energy synthesis, reactive oxygen species balancing, antiapoptotic molecule production, membrane stability, intracellular calcium buffering, neuroplasticity and neurotransmission. Dysfunction in mitochondria is considered to be involved in the pathophys...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Open Exploration Publishing Inc.
2022-10-01
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| Series: | Exploration of Medicine |
| Subjects: | |
| Online Access: | https://www.explorationpub.com/Journals/em/Article/1001110 |
| _version_ | 1828099521916174336 |
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| author | Monu Yadav Mini Dahiya Jyoti Dagar Narender Singh Nidhi Sharma Nitin Rawat Pratibha Dhakla Neha Minocha Anil Kumar |
| author_facet | Monu Yadav Mini Dahiya Jyoti Dagar Narender Singh Nidhi Sharma Nitin Rawat Pratibha Dhakla Neha Minocha Anil Kumar |
| author_sort | Monu Yadav |
| collection | DOAJ |
| description | Mitochondria are important organelles for high energy synthesis, reactive oxygen species balancing, antiapoptotic molecule production, membrane stability, intracellular calcium buffering, neuroplasticity and neurotransmission. Dysfunction in mitochondria is considered to be involved in the pathophysiology of mental problems. It has been observed that several drug types used to treat brain illnesses can harm mitochondria by altering the oxidative phosphorylation system and the gene expression of mitochondria-related proteins. In some studies, it has been observed that mitochondrial biogenesis shows a therapeutic effect in the management of mitochondrial disorders. Many therapeutic compounds are effective in the activation of mitochondrial biogenesis. The comorbidity of mental problems observed in those with mitochondrial dysfunction and the change in the efficacy of the cellular respiratory system have attracted researchers to understand the pathways and possible therapeutic strategies in neurological disorders. This article has attempted to understand the impact of mitochondrial function and mitochondrial dysfunction in the pathogenesis of brain disorders to develop potential therapeutic drugs. |
| first_indexed | 2024-04-11T08:16:15Z |
| format | Article |
| id | doaj.art-ac59107956b4472da2b42a9e3bb5e8c1 |
| institution | Directory Open Access Journal |
| issn | 2692-3106 |
| language | English |
| last_indexed | 2024-04-11T08:16:15Z |
| publishDate | 2022-10-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Medicine |
| spelling | doaj.art-ac59107956b4472da2b42a9e3bb5e8c12022-12-22T04:35:09ZengOpen Exploration Publishing Inc.Exploration of Medicine2692-31062022-10-013549451510.37349/emed.2022.00110Role of mitochondria in brain functions and related disordersMonu Yadav0https://orcid.org/0000-0002-3003-4186Mini Dahiya1https://orcid.org/0000-0001-8887-7322Jyoti Dagar2Narender Singh3Nidhi Sharma4https://orcid.org/0000-0002-5904-4185Nitin Rawat5Pratibha Dhakla6Neha Minocha7https://orcid.org/0000-0002-0870-4972Anil Kumar8University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies (UGC-CAS), Panjab University, Chandigarh 160014, India; Department of Pharmacy, School of Medical & Allied Sciences, GD Goenka University, Gurugram 122103, IndiaUniversity Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies (UGC-CAS), Panjab University, Chandigarh 160014, IndiaDepartment of Pharmacy, School of Medical & Allied Sciences, GD Goenka University, Gurugram 122103, IndiaDepartment of Pharmacy, School of Medical & Allied Sciences, GD Goenka University, Gurugram 122103, IndiaDr. K.N. Modi Institute of Pharmaceutical Education and Research, Modinagar 201204, Uttar Pradesh, IndiaUniversity Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies (UGC-CAS), Panjab University, Chandigarh 160014, IndiaDepartment of Pharmacy, School of Medical & Allied Sciences, GD Goenka University, Gurugram 122103, IndiaSchool of Medical & Allied Sciences, K. R. Mangalam University, Gurugram 122103, Haryana, IndiaUniversity Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies (UGC-CAS), Panjab University, Chandigarh 160014, IndiaMitochondria are important organelles for high energy synthesis, reactive oxygen species balancing, antiapoptotic molecule production, membrane stability, intracellular calcium buffering, neuroplasticity and neurotransmission. Dysfunction in mitochondria is considered to be involved in the pathophysiology of mental problems. It has been observed that several drug types used to treat brain illnesses can harm mitochondria by altering the oxidative phosphorylation system and the gene expression of mitochondria-related proteins. In some studies, it has been observed that mitochondrial biogenesis shows a therapeutic effect in the management of mitochondrial disorders. Many therapeutic compounds are effective in the activation of mitochondrial biogenesis. The comorbidity of mental problems observed in those with mitochondrial dysfunction and the change in the efficacy of the cellular respiratory system have attracted researchers to understand the pathways and possible therapeutic strategies in neurological disorders. This article has attempted to understand the impact of mitochondrial function and mitochondrial dysfunction in the pathogenesis of brain disorders to develop potential therapeutic drugs.https://www.explorationpub.com/Journals/em/Article/1001110mitochondriamitochondrial functionmitochondrial dysfunctionneurological disorder |
| spellingShingle | Monu Yadav Mini Dahiya Jyoti Dagar Narender Singh Nidhi Sharma Nitin Rawat Pratibha Dhakla Neha Minocha Anil Kumar Role of mitochondria in brain functions and related disorders Exploration of Medicine mitochondria mitochondrial function mitochondrial dysfunction neurological disorder |
| title | Role of mitochondria in brain functions and related disorders |
| title_full | Role of mitochondria in brain functions and related disorders |
| title_fullStr | Role of mitochondria in brain functions and related disorders |
| title_full_unstemmed | Role of mitochondria in brain functions and related disorders |
| title_short | Role of mitochondria in brain functions and related disorders |
| title_sort | role of mitochondria in brain functions and related disorders |
| topic | mitochondria mitochondrial function mitochondrial dysfunction neurological disorder |
| url | https://www.explorationpub.com/Journals/em/Article/1001110 |
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