Antihyperalgesic and Antiallodynic Effects of Amarisolide A and <i>Salvia amarissima</i> Ortega in Experimental Fibromyalgia-Type Pain
<i>Salvia amarissima</i> Ortega is an endemic species of Mexico used in folk medicine to alleviate pain and as a nervous tranquilizer. The <i>S. amarissima</i> extract and one of its abundant metabolites, identified and isolated through chromatographic techniques, were invest...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/13/1/59 |
| _version_ | 1827623299373334528 |
|---|---|
| author | Gabriel Fernando Moreno-Pérez María Eva González-Trujano Alberto Hernandez-Leon María Guadalupe Valle-Dorado Alejandro Valdés-Cruz Noé Alvarado-Vásquez Eva Aguirre-Hernández Hermelinda Salgado-Ceballos Francisco Pellicer |
| author_facet | Gabriel Fernando Moreno-Pérez María Eva González-Trujano Alberto Hernandez-Leon María Guadalupe Valle-Dorado Alejandro Valdés-Cruz Noé Alvarado-Vásquez Eva Aguirre-Hernández Hermelinda Salgado-Ceballos Francisco Pellicer |
| author_sort | Gabriel Fernando Moreno-Pérez |
| collection | DOAJ |
| description | <i>Salvia amarissima</i> Ortega is an endemic species of Mexico used in folk medicine to alleviate pain and as a nervous tranquilizer. The <i>S. amarissima</i> extract and one of its abundant metabolites, identified and isolated through chromatographic techniques, were investigated to obtain scientific evidence of its potential effects to relieve nociplastic pain such as fibromyalgia. Then, the extract and amarisolide A (3–300 mg/kg, i.p.) were pharmacologically evaluated in reserpine-induced fibromyalgia-type chronic pain and in depressive-like behavior (as a common comorbidity) by using the forced swimming test in rats. The 5-HT<sub>1A</sub> serotonin receptor (selective antagonist WAY100635, 1 mg/kg, i.p.) was explored after the prediction of a chemical interaction using in silico analysis to look for a possible mechanism of action of amarisolide A. Both the extract and amarisolide A produced significant and dose-dependent antihyperalgesic and antiallodynic effects in rats, as well as significant antidepressive behavior without sedative effects when the antinociceptive dosages were used. The 5-HT<sub>1A</sub> serotonin receptor participation was predicted by the in silico descriptors and was corroborated in the presence of WAY100635. In conclusion, <i>S. amarissima</i> possesses antihyperalgesic, antiallodynic, and anti-depressive activities, partially due to the presence of amarisolide A, which involves the 5-HT<sub>1A</sub> serotonin receptor. This pharmacological evidence suggests that <i>S. amarissima</i> and amarisolide A are both potential alternatives to relieve pain-like fibromyalgia. |
| first_indexed | 2024-03-09T11:43:46Z |
| format | Article |
| id | doaj.art-ac5944ddc80d4ba9b07565ac6707d4cc |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T11:43:46Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-ac5944ddc80d4ba9b07565ac6707d4cc2023-11-30T23:28:26ZengMDPI AGMetabolites2218-19892022-12-011315910.3390/metabo13010059Antihyperalgesic and Antiallodynic Effects of Amarisolide A and <i>Salvia amarissima</i> Ortega in Experimental Fibromyalgia-Type PainGabriel Fernando Moreno-Pérez0María Eva González-Trujano1Alberto Hernandez-Leon2María Guadalupe Valle-Dorado3Alejandro Valdés-Cruz4Noé Alvarado-Vásquez5Eva Aguirre-Hernández6Hermelinda Salgado-Ceballos7Francisco Pellicer8Laboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Ciudad de México 14370, MexicoLaboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Ciudad de México 14370, MexicoLaboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Ciudad de México 14370, MexicoLaboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Ciudad de México 14370, MexicoLaboratorio de Neurofisiología del Control y la Regulación, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Ciudad de México 14370, MexicoDepartamento de Bioquímica, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Calz. de Tlalpan 4502, Col. Sección XVI, Tlalpan, Ciudad de México 14080, MexicoLaboratorio de Productos Naturales, Departamento de Ecología y Recursos Naturales, Facultad de Ciencias, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510, MexicoUnidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS, Ciudad de México 06720, MexicoLaboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Ciudad de México 14370, Mexico<i>Salvia amarissima</i> Ortega is an endemic species of Mexico used in folk medicine to alleviate pain and as a nervous tranquilizer. The <i>S. amarissima</i> extract and one of its abundant metabolites, identified and isolated through chromatographic techniques, were investigated to obtain scientific evidence of its potential effects to relieve nociplastic pain such as fibromyalgia. Then, the extract and amarisolide A (3–300 mg/kg, i.p.) were pharmacologically evaluated in reserpine-induced fibromyalgia-type chronic pain and in depressive-like behavior (as a common comorbidity) by using the forced swimming test in rats. The 5-HT<sub>1A</sub> serotonin receptor (selective antagonist WAY100635, 1 mg/kg, i.p.) was explored after the prediction of a chemical interaction using in silico analysis to look for a possible mechanism of action of amarisolide A. Both the extract and amarisolide A produced significant and dose-dependent antihyperalgesic and antiallodynic effects in rats, as well as significant antidepressive behavior without sedative effects when the antinociceptive dosages were used. The 5-HT<sub>1A</sub> serotonin receptor participation was predicted by the in silico descriptors and was corroborated in the presence of WAY100635. In conclusion, <i>S. amarissima</i> possesses antihyperalgesic, antiallodynic, and anti-depressive activities, partially due to the presence of amarisolide A, which involves the 5-HT<sub>1A</sub> serotonin receptor. This pharmacological evidence suggests that <i>S. amarissima</i> and amarisolide A are both potential alternatives to relieve pain-like fibromyalgia.https://www.mdpi.com/2218-1989/13/1/59nociplastic paindepressionfibromyalgianeoclerodane diterpene<i>Salvia</i> |
| spellingShingle | Gabriel Fernando Moreno-Pérez María Eva González-Trujano Alberto Hernandez-Leon María Guadalupe Valle-Dorado Alejandro Valdés-Cruz Noé Alvarado-Vásquez Eva Aguirre-Hernández Hermelinda Salgado-Ceballos Francisco Pellicer Antihyperalgesic and Antiallodynic Effects of Amarisolide A and <i>Salvia amarissima</i> Ortega in Experimental Fibromyalgia-Type Pain Metabolites nociplastic pain depression fibromyalgia neoclerodane diterpene <i>Salvia</i> |
| title | Antihyperalgesic and Antiallodynic Effects of Amarisolide A and <i>Salvia amarissima</i> Ortega in Experimental Fibromyalgia-Type Pain |
| title_full | Antihyperalgesic and Antiallodynic Effects of Amarisolide A and <i>Salvia amarissima</i> Ortega in Experimental Fibromyalgia-Type Pain |
| title_fullStr | Antihyperalgesic and Antiallodynic Effects of Amarisolide A and <i>Salvia amarissima</i> Ortega in Experimental Fibromyalgia-Type Pain |
| title_full_unstemmed | Antihyperalgesic and Antiallodynic Effects of Amarisolide A and <i>Salvia amarissima</i> Ortega in Experimental Fibromyalgia-Type Pain |
| title_short | Antihyperalgesic and Antiallodynic Effects of Amarisolide A and <i>Salvia amarissima</i> Ortega in Experimental Fibromyalgia-Type Pain |
| title_sort | antihyperalgesic and antiallodynic effects of amarisolide a and i salvia amarissima i ortega in experimental fibromyalgia type pain |
| topic | nociplastic pain depression fibromyalgia neoclerodane diterpene <i>Salvia</i> |
| url | https://www.mdpi.com/2218-1989/13/1/59 |
| work_keys_str_mv | AT gabrielfernandomorenoperez antihyperalgesicandantiallodyniceffectsofamarisolideaandisalviaamarissimaiortegainexperimentalfibromyalgiatypepain AT mariaevagonzaleztrujano antihyperalgesicandantiallodyniceffectsofamarisolideaandisalviaamarissimaiortegainexperimentalfibromyalgiatypepain AT albertohernandezleon antihyperalgesicandantiallodyniceffectsofamarisolideaandisalviaamarissimaiortegainexperimentalfibromyalgiatypepain AT mariaguadalupevalledorado antihyperalgesicandantiallodyniceffectsofamarisolideaandisalviaamarissimaiortegainexperimentalfibromyalgiatypepain AT alejandrovaldescruz antihyperalgesicandantiallodyniceffectsofamarisolideaandisalviaamarissimaiortegainexperimentalfibromyalgiatypepain AT noealvaradovasquez antihyperalgesicandantiallodyniceffectsofamarisolideaandisalviaamarissimaiortegainexperimentalfibromyalgiatypepain AT evaaguirrehernandez antihyperalgesicandantiallodyniceffectsofamarisolideaandisalviaamarissimaiortegainexperimentalfibromyalgiatypepain AT hermelindasalgadoceballos antihyperalgesicandantiallodyniceffectsofamarisolideaandisalviaamarissimaiortegainexperimentalfibromyalgiatypepain AT franciscopellicer antihyperalgesicandantiallodyniceffectsofamarisolideaandisalviaamarissimaiortegainexperimentalfibromyalgiatypepain |