Doxofylline ameliorates liver fibrosis by regulating the ferroptosis signaling pathway

Doxofylline ameliorates liver fibrosis by regulating the ferroptosis signaling pathway

Liver fibrosis, a compensatory repair response to chronic liver injury, is caused by various pathogenic factors, and hepatic stellate cell (HSC) activation and phenotypic transformation are regarded as key events in its progression. Ferroptosis, a novel form of programmed cell death, is also closely...

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Bibliographic Details
Main Authors:	Lenan Xu, Meiling Zhang, Junzhi Pan, Xiangwei Xu, Yawen Zhang, Xue Han, Lina Yin, Lingfeng Chen, Juan Ren, Jie Yu, Yanmei Zhang, Guang Liang, Yi Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-03-01
Series:	Frontiers in Pharmacology
Subjects:	liver fibrosis doxofylline hepatic stellate cells ferroptosis deferoxamine (DFO)
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1135366/full

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