Phase Angle as a Comprehensive Tool for Nutritional Monitoring and Management in Patients with Crohn’s Disease
Background and Aims: Crohn’s disease (CD) is usually accompanied by malnutrition. CD-related malnutrition can increase morbidity, disability, mortality, and hospitalization costs. The purpose of this study was to find a reliable indicator for evaluating CD patients’ nutritional status. Methods: All...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/11/2260 |
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| author | Ziheng Peng Duo Xu Yong Li Yu Peng Xiaowei Liu |
| author_facet | Ziheng Peng Duo Xu Yong Li Yu Peng Xiaowei Liu |
| author_sort | Ziheng Peng |
| collection | DOAJ |
| description | Background and Aims: Crohn’s disease (CD) is usually accompanied by malnutrition. CD-related malnutrition can increase morbidity, disability, mortality, and hospitalization costs. The purpose of this study was to find a reliable indicator for evaluating CD patients’ nutritional status. Methods: All data were retrospectively collected from Xiangya Hospital, Central South University between May 2021 and February 2022. All patients were evaluated for nutritional status using the Global Leadership Initiative on Malnutrition (GLIM) criteria. Body composition, resistance, and reactance were recorded by a body analyser, and the phase angle (PhA) was calculated simultaneously. The Mann–Whitney U test, chi-square test, Fisher’s exact test, and univariate and multivariate logistic regression analyses were used. A receiver operating characteristic (ROC) curve was built to evaluate the predictive value of differential variables for diagnosing malnutrition based on the GLIM criteria. Results: A total of 169 CD patients were enrolled, of which 74 (58.3%) males and 32 (76.2%) females were diagnosed with malnutrition; 34 (45.9%) males and 22 (68.8%) females were severely malnourished. Univariate analysis identified that as nutritional status deteriorated, body mass index, PhA, and levels of haemoglobin and albumin decreased, while platelet count, erythrocyte sedimentation rate, and levels of C-reactive protein and fibrinogen increased (<i>p</i> < 0.05). Logistic regression analysis revealed that the PhA was significantly independently associated with malnutrition (<i>p</i> < 0.05). The ROC curve analysis indicated that the optimal PhA cut-off levels of 6.11° and 5.55° could be used to predict malnutrition according to the GLIM criteria in males and females, respectively, with a PhA < 5.53° and < 5.12° indicating severe malnutrition in males and females, respectively. Conclusion: The PhA is a sensitive, noninvasive, portable, inexpensive tool that can be used to monitor and manage the nutritional status of CD patients. |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T01:00:52Z |
| publishDate | 2022-05-01 |
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| series | Nutrients |
| spelling | doaj.art-ac5a8f32e56742c4a8a1a9558354475d2023-11-23T14:36:11ZengMDPI AGNutrients2072-66432022-05-011411226010.3390/nu14112260Phase Angle as a Comprehensive Tool for Nutritional Monitoring and Management in Patients with Crohn’s DiseaseZiheng Peng0Duo Xu1Yong Li2Yu Peng3Xiaowei Liu4Department of Gastroenterology, Xiangya Hospital of Central South University, Changsha 410008, ChinaDepartment of Gastroenterology, Xiangya Hospital of Central South University, Changsha 410008, ChinaDepartment of Gastroenterology, Xiangya Hospital of Central South University, Changsha 410008, ChinaDepartment of Gastroenterology, Xiangya Hospital of Central South University, Changsha 410008, ChinaDepartment of Gastroenterology, Xiangya Hospital of Central South University, Changsha 410008, ChinaBackground and Aims: Crohn’s disease (CD) is usually accompanied by malnutrition. CD-related malnutrition can increase morbidity, disability, mortality, and hospitalization costs. The purpose of this study was to find a reliable indicator for evaluating CD patients’ nutritional status. Methods: All data were retrospectively collected from Xiangya Hospital, Central South University between May 2021 and February 2022. All patients were evaluated for nutritional status using the Global Leadership Initiative on Malnutrition (GLIM) criteria. Body composition, resistance, and reactance were recorded by a body analyser, and the phase angle (PhA) was calculated simultaneously. The Mann–Whitney U test, chi-square test, Fisher’s exact test, and univariate and multivariate logistic regression analyses were used. A receiver operating characteristic (ROC) curve was built to evaluate the predictive value of differential variables for diagnosing malnutrition based on the GLIM criteria. Results: A total of 169 CD patients were enrolled, of which 74 (58.3%) males and 32 (76.2%) females were diagnosed with malnutrition; 34 (45.9%) males and 22 (68.8%) females were severely malnourished. Univariate analysis identified that as nutritional status deteriorated, body mass index, PhA, and levels of haemoglobin and albumin decreased, while platelet count, erythrocyte sedimentation rate, and levels of C-reactive protein and fibrinogen increased (<i>p</i> < 0.05). Logistic regression analysis revealed that the PhA was significantly independently associated with malnutrition (<i>p</i> < 0.05). The ROC curve analysis indicated that the optimal PhA cut-off levels of 6.11° and 5.55° could be used to predict malnutrition according to the GLIM criteria in males and females, respectively, with a PhA < 5.53° and < 5.12° indicating severe malnutrition in males and females, respectively. Conclusion: The PhA is a sensitive, noninvasive, portable, inexpensive tool that can be used to monitor and manage the nutritional status of CD patients.https://www.mdpi.com/2072-6643/14/11/2260phase angleCrohn’s diseaseGLIMnutritional statusnutritional monitoring and management |
| spellingShingle | Ziheng Peng Duo Xu Yong Li Yu Peng Xiaowei Liu Phase Angle as a Comprehensive Tool for Nutritional Monitoring and Management in Patients with Crohn’s Disease Nutrients phase angle Crohn’s disease GLIM nutritional status nutritional monitoring and management |
| title | Phase Angle as a Comprehensive Tool for Nutritional Monitoring and Management in Patients with Crohn’s Disease |
| title_full | Phase Angle as a Comprehensive Tool for Nutritional Monitoring and Management in Patients with Crohn’s Disease |
| title_fullStr | Phase Angle as a Comprehensive Tool for Nutritional Monitoring and Management in Patients with Crohn’s Disease |
| title_full_unstemmed | Phase Angle as a Comprehensive Tool for Nutritional Monitoring and Management in Patients with Crohn’s Disease |
| title_short | Phase Angle as a Comprehensive Tool for Nutritional Monitoring and Management in Patients with Crohn’s Disease |
| title_sort | phase angle as a comprehensive tool for nutritional monitoring and management in patients with crohn s disease |
| topic | phase angle Crohn’s disease GLIM nutritional status nutritional monitoring and management |
| url | https://www.mdpi.com/2072-6643/14/11/2260 |
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