Critical Overview of Hepatic Factors That Link Non-Alcoholic Fatty Liver Disease and Acute Kidney Injury: Physiology and Therapeutic Implications
Non-alcoholic fatty liver disease (NAFLD) is defined as a combination of a group of progressive diseases, presenting different structural features of the liver at different stages of the disease. According to epidemiological surveys, as living standards improve, the global prevalence of NAFLD increa...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/20/12464 |
| _version_ | 1797472779232083968 |
|---|---|
| author | Le Chen Xiaodong Lv Min Kan Ruonan Wang Hua Wang Hongmei Zang |
| author_facet | Le Chen Xiaodong Lv Min Kan Ruonan Wang Hua Wang Hongmei Zang |
| author_sort | Le Chen |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) is defined as a combination of a group of progressive diseases, presenting different structural features of the liver at different stages of the disease. According to epidemiological surveys, as living standards improve, the global prevalence of NAFLD increases. Acute kidney injury (AKI) is a class of clinical conditions characterized by a rapid decline in kidney function. NAFLD and AKI, as major public health diseases with high prevalence and mortality, respectively, worldwide, place a heavy burden on societal healthcare systems. Clinical observations of patients with NAFLD with AKI suggest a possible association between the two diseases. However, little is known about the pathogenic mechanisms linking NAFLD and AKI, and the combination of the diseases is poorly treated. Previous studies have revealed that liver-derived factors are transported to distal organs via circulation, such as the kidney, where they elicit specific effects. Of note, while NAFLD affects the expression of many hepatic factors, studies on the mechanisms whereby NAFLD mediates the generation of hepatic factors that lead to AKI are lacking. Considering the unique positioning of hepatic factors in coordinating systemic energy metabolism and maintaining energy homeostasis, we hypothesize that the effects of NAFLD are not only limited to the structural and functional changes in the liver but may also involve the entire body via the hepatic factors, e.g., playing an important role in the development of AKI. This raises the question of whether analogs of beneficial hepatic factors or inhibitors of detrimental hepatic factors could be used as a treatment for NAFLD-mediated and hepatic factor-driven AKI or other metabolic disorders. Accordingly, in this review, we describe the systemic effects of several types of hepatic factors, with a particular focus on the possible link between hepatic factors whose expression is altered under NAFLD and AKI. We also summarize the role of some key hepatic factors in metabolic control mechanisms and discuss their possible use as a preventive treatment for the progression of metabolic diseases. |
| first_indexed | 2024-03-09T20:06:05Z |
| format | Article |
| id | doaj.art-ac5c88f51fe5486ebdad2ae4017b44b1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T20:06:05Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ac5c88f51fe5486ebdad2ae4017b44b12023-11-24T00:31:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123201246410.3390/ijms232012464Critical Overview of Hepatic Factors That Link Non-Alcoholic Fatty Liver Disease and Acute Kidney Injury: Physiology and Therapeutic ImplicationsLe Chen0Xiaodong Lv1Min Kan2Ruonan Wang3Hua Wang4Hongmei Zang5Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, The Key Laboratory of Anti-Inflammatory of Immune Medicines, School of Pharmacy, Anhui Medical University, Hefei 230032, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, The Key Laboratory of Anti-Inflammatory of Immune Medicines, School of Pharmacy, Anhui Medical University, Hefei 230032, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, The Key Laboratory of Anti-Inflammatory of Immune Medicines, School of Pharmacy, Anhui Medical University, Hefei 230032, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, The Key Laboratory of Anti-Inflammatory of Immune Medicines, School of Pharmacy, Anhui Medical University, Hefei 230032, ChinaDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, The Key Laboratory of Anti-Inflammatory of Immune Medicines, School of Pharmacy, Anhui Medical University, Hefei 230032, ChinaNon-alcoholic fatty liver disease (NAFLD) is defined as a combination of a group of progressive diseases, presenting different structural features of the liver at different stages of the disease. According to epidemiological surveys, as living standards improve, the global prevalence of NAFLD increases. Acute kidney injury (AKI) is a class of clinical conditions characterized by a rapid decline in kidney function. NAFLD and AKI, as major public health diseases with high prevalence and mortality, respectively, worldwide, place a heavy burden on societal healthcare systems. Clinical observations of patients with NAFLD with AKI suggest a possible association between the two diseases. However, little is known about the pathogenic mechanisms linking NAFLD and AKI, and the combination of the diseases is poorly treated. Previous studies have revealed that liver-derived factors are transported to distal organs via circulation, such as the kidney, where they elicit specific effects. Of note, while NAFLD affects the expression of many hepatic factors, studies on the mechanisms whereby NAFLD mediates the generation of hepatic factors that lead to AKI are lacking. Considering the unique positioning of hepatic factors in coordinating systemic energy metabolism and maintaining energy homeostasis, we hypothesize that the effects of NAFLD are not only limited to the structural and functional changes in the liver but may also involve the entire body via the hepatic factors, e.g., playing an important role in the development of AKI. This raises the question of whether analogs of beneficial hepatic factors or inhibitors of detrimental hepatic factors could be used as a treatment for NAFLD-mediated and hepatic factor-driven AKI or other metabolic disorders. Accordingly, in this review, we describe the systemic effects of several types of hepatic factors, with a particular focus on the possible link between hepatic factors whose expression is altered under NAFLD and AKI. We also summarize the role of some key hepatic factors in metabolic control mechanisms and discuss their possible use as a preventive treatment for the progression of metabolic diseases.https://www.mdpi.com/1422-0067/23/20/12464nonalcoholic fatty liveracute kidney injuryrenal functionhepatic factorhepatic-renal axis |
| spellingShingle | Le Chen Xiaodong Lv Min Kan Ruonan Wang Hua Wang Hongmei Zang Critical Overview of Hepatic Factors That Link Non-Alcoholic Fatty Liver Disease and Acute Kidney Injury: Physiology and Therapeutic Implications International Journal of Molecular Sciences nonalcoholic fatty liver acute kidney injury renal function hepatic factor hepatic-renal axis |
| title | Critical Overview of Hepatic Factors That Link Non-Alcoholic Fatty Liver Disease and Acute Kidney Injury: Physiology and Therapeutic Implications |
| title_full | Critical Overview of Hepatic Factors That Link Non-Alcoholic Fatty Liver Disease and Acute Kidney Injury: Physiology and Therapeutic Implications |
| title_fullStr | Critical Overview of Hepatic Factors That Link Non-Alcoholic Fatty Liver Disease and Acute Kidney Injury: Physiology and Therapeutic Implications |
| title_full_unstemmed | Critical Overview of Hepatic Factors That Link Non-Alcoholic Fatty Liver Disease and Acute Kidney Injury: Physiology and Therapeutic Implications |
| title_short | Critical Overview of Hepatic Factors That Link Non-Alcoholic Fatty Liver Disease and Acute Kidney Injury: Physiology and Therapeutic Implications |
| title_sort | critical overview of hepatic factors that link non alcoholic fatty liver disease and acute kidney injury physiology and therapeutic implications |
| topic | nonalcoholic fatty liver acute kidney injury renal function hepatic factor hepatic-renal axis |
| url | https://www.mdpi.com/1422-0067/23/20/12464 |
| work_keys_str_mv | AT lechen criticaloverviewofhepaticfactorsthatlinknonalcoholicfattyliverdiseaseandacutekidneyinjuryphysiologyandtherapeuticimplications AT xiaodonglv criticaloverviewofhepaticfactorsthatlinknonalcoholicfattyliverdiseaseandacutekidneyinjuryphysiologyandtherapeuticimplications AT minkan criticaloverviewofhepaticfactorsthatlinknonalcoholicfattyliverdiseaseandacutekidneyinjuryphysiologyandtherapeuticimplications AT ruonanwang criticaloverviewofhepaticfactorsthatlinknonalcoholicfattyliverdiseaseandacutekidneyinjuryphysiologyandtherapeuticimplications AT huawang criticaloverviewofhepaticfactorsthatlinknonalcoholicfattyliverdiseaseandacutekidneyinjuryphysiologyandtherapeuticimplications AT hongmeizang criticaloverviewofhepaticfactorsthatlinknonalcoholicfattyliverdiseaseandacutekidneyinjuryphysiologyandtherapeuticimplications |