Tumor-overexpressed enzyme responsive amphiphiles small molecular self-assembly nano-prodrug for the chemo-phototherapy against non-small-cell lung cancer
Rational design of self-assembly drug amphiphiles can provide a promising strategy for constructing nano-prodrug with high drug loading, smart stimuli-responsive drug release and high tumor selectivity. Herein, we report a small molecular amphiphile prodrug that can self-assemble into multifunctiona...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006423001825 |
| _version_ | 1797770757289279488 |
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| author | Peilian Liu Yong Huang Chenyue Zhan Fu Zhang Chuansen Deng Yongmei Jia Tao Wan Sheng Wang Bowen Li |
| author_facet | Peilian Liu Yong Huang Chenyue Zhan Fu Zhang Chuansen Deng Yongmei Jia Tao Wan Sheng Wang Bowen Li |
| author_sort | Peilian Liu |
| collection | DOAJ |
| description | Rational design of self-assembly drug amphiphiles can provide a promising strategy for constructing nano-prodrug with high drug loading, smart stimuli-responsive drug release and high tumor selectivity. Herein, we report a small molecular amphiphile prodrug that can self-assemble into multifunctional nano-prodrug for enhanced anticancer effect by the combination of chemotherapy and phototherapy (PDT/PTT). In this prodrug, the simple insertion of quinone propionate into hydrophilic drug Irinotecan (Ir) generates suitable amphiphiles that endow a good self-assembly behavior of the prodrug and transform it into a stable and uniform nanoparticle. Interestingly, this excellent self-assembly behavior can load phototherapy agent ICG to form a multifunctional nano-prodrug, thereby enhancing the chemotherapeutic effect with PDT/PTT. Importantly, the quinone propionic acid moiety in the prodrug showed a high sensitivity to the overexpressed NAD(P)H:quinone oxidoreductase-1 (NQO1) in non-small cell lung cancer (NSCLC) cells, and this sensitivity enables the disassembly of nano-prodrug and efficient NQO1-responsive drug release. To further enhance the drug accumulation on tumor tissue and migrate the blood clearance, a biomimetic nano-prodrug has been successfully explored by coating hybrid membrane on the above nano-prodrug, which displays high selective inhibition of tumor growth and metastasis on NSCLC mice model. Our findings provide new insights into the rational design of tumor-overexpressed enzyme responsive nano-prodrug for cancer combinational therapy. |
| first_indexed | 2024-03-12T21:27:53Z |
| format | Article |
| id | doaj.art-ac5d9a76aa8345b1b66518cdf6681eef |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-03-12T21:27:53Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-ac5d9a76aa8345b1b66518cdf6681eef2023-07-28T04:26:45ZengElsevierMaterials Today Bio2590-00642023-08-0121100722Tumor-overexpressed enzyme responsive amphiphiles small molecular self-assembly nano-prodrug for the chemo-phototherapy against non-small-cell lung cancerPeilian Liu0Yong Huang1Chenyue Zhan2Fu Zhang3Chuansen Deng4Yongmei Jia5Tao Wan6Sheng Wang7Bowen Li8School of Chemistry and Chemical Engineering, Key Laboratory of Clean Energy Materials Chemistry in Guangdong General University, Lingnan Normal University, Zhanjiang, 524048, PR China; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR ChinaCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, School of Medicine, Zhejiang University, Hangzhou, 310003, PR China; Corresponding author. Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117585, Singapore.Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, School of Medicine, Zhejiang University, Hangzhou, 310003, PR ChinaSchool of Chemistry and Chemical Engineering, Key Laboratory of Clean Energy Materials Chemistry in Guangdong General University, Lingnan Normal University, Zhanjiang, 524048, PR ChinaSchool of Chemistry and Chemical Engineering, Key Laboratory of Clean Energy Materials Chemistry in Guangdong General University, Lingnan Normal University, Zhanjiang, 524048, PR ChinaCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR ChinaSchool of Chemistry and Chemical Engineering, Key Laboratory of Clean Energy Materials Chemistry in Guangdong General University, Lingnan Normal University, Zhanjiang, 524048, PR China; Corresponding author. Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117585, Singapore.Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117585, Singapore; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China; Corresponding author. Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117585, Singapore.Rational design of self-assembly drug amphiphiles can provide a promising strategy for constructing nano-prodrug with high drug loading, smart stimuli-responsive drug release and high tumor selectivity. Herein, we report a small molecular amphiphile prodrug that can self-assemble into multifunctional nano-prodrug for enhanced anticancer effect by the combination of chemotherapy and phototherapy (PDT/PTT). In this prodrug, the simple insertion of quinone propionate into hydrophilic drug Irinotecan (Ir) generates suitable amphiphiles that endow a good self-assembly behavior of the prodrug and transform it into a stable and uniform nanoparticle. Interestingly, this excellent self-assembly behavior can load phototherapy agent ICG to form a multifunctional nano-prodrug, thereby enhancing the chemotherapeutic effect with PDT/PTT. Importantly, the quinone propionic acid moiety in the prodrug showed a high sensitivity to the overexpressed NAD(P)H:quinone oxidoreductase-1 (NQO1) in non-small cell lung cancer (NSCLC) cells, and this sensitivity enables the disassembly of nano-prodrug and efficient NQO1-responsive drug release. To further enhance the drug accumulation on tumor tissue and migrate the blood clearance, a biomimetic nano-prodrug has been successfully explored by coating hybrid membrane on the above nano-prodrug, which displays high selective inhibition of tumor growth and metastasis on NSCLC mice model. Our findings provide new insights into the rational design of tumor-overexpressed enzyme responsive nano-prodrug for cancer combinational therapy.http://www.sciencedirect.com/science/article/pii/S2590006423001825Nano-prodrugNQO1-ResponsiveSelf-assemblyAmphiphiles small molecularCombinational therapy |
| spellingShingle | Peilian Liu Yong Huang Chenyue Zhan Fu Zhang Chuansen Deng Yongmei Jia Tao Wan Sheng Wang Bowen Li Tumor-overexpressed enzyme responsive amphiphiles small molecular self-assembly nano-prodrug for the chemo-phototherapy against non-small-cell lung cancer Materials Today Bio Nano-prodrug NQO1-Responsive Self-assembly Amphiphiles small molecular Combinational therapy |
| title | Tumor-overexpressed enzyme responsive amphiphiles small molecular self-assembly nano-prodrug for the chemo-phototherapy against non-small-cell lung cancer |
| title_full | Tumor-overexpressed enzyme responsive amphiphiles small molecular self-assembly nano-prodrug for the chemo-phototherapy against non-small-cell lung cancer |
| title_fullStr | Tumor-overexpressed enzyme responsive amphiphiles small molecular self-assembly nano-prodrug for the chemo-phototherapy against non-small-cell lung cancer |
| title_full_unstemmed | Tumor-overexpressed enzyme responsive amphiphiles small molecular self-assembly nano-prodrug for the chemo-phototherapy against non-small-cell lung cancer |
| title_short | Tumor-overexpressed enzyme responsive amphiphiles small molecular self-assembly nano-prodrug for the chemo-phototherapy against non-small-cell lung cancer |
| title_sort | tumor overexpressed enzyme responsive amphiphiles small molecular self assembly nano prodrug for the chemo phototherapy against non small cell lung cancer |
| topic | Nano-prodrug NQO1-Responsive Self-assembly Amphiphiles small molecular Combinational therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2590006423001825 |
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