GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis
Abstract. GSDME contains a pore-forming domain at its N-terminal region to execute pyroptosis. Our previous study has reported that forced expression of Gsdme impairs the reconstitution capacity of hematopoietic stem cells (HSCs). While, how GSDME-mediated pyroptosis regulates HSCs remains unknown....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health
2021-04-01
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| Series: | Blood Science |
| Online Access: | http://journals.lww.com/10.1097/BS9.0000000000000064 |
| _version_ | 1818744646672580608 |
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| author | Xiuxiu Yang Tingting Cong Hanqing He Jianwei Wang |
| author_facet | Xiuxiu Yang Tingting Cong Hanqing He Jianwei Wang |
| author_sort | Xiuxiu Yang |
| collection | DOAJ |
| description | Abstract. GSDME contains a pore-forming domain at its N-terminal region to execute pyroptosis. Our previous study has reported that forced expression of Gsdme impairs the reconstitution capacity of hematopoietic stem cells (HSCs). While, how GSDME-mediated pyroptosis regulates HSCs remains unknown. Here, we show that hematopoietic stem and progenitor cells are capable to undergo pyroptosis in response to cisplatin treatment and GSDME is one of the genes mediating such process. Gsdme−/− mice revealed no difference in the steady state of blood system while Gsdme−/− HSCs exhibited compromised reconstitution capacity due to increased apoptosis. Briefly, this study reveals that GSDME modulates HSC function by coordinating pyroptosis and apoptosis. |
| first_indexed | 2024-12-18T02:47:37Z |
| format | Article |
| id | doaj.art-ac5dd5e4eb0d4e238ac9f2f03d6fcf29 |
| institution | Directory Open Access Journal |
| issn | 2543-6368 |
| language | English |
| last_indexed | 2024-12-18T02:47:37Z |
| publishDate | 2021-04-01 |
| publisher | Wolters Kluwer Health |
| record_format | Article |
| series | Blood Science |
| spelling | doaj.art-ac5dd5e4eb0d4e238ac9f2f03d6fcf292022-12-21T21:23:32ZengWolters Kluwer HealthBlood Science2543-63682021-04-0132404710.1097/BS9.0000000000000064202104000-00004GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosisXiuxiu Yang0Tingting Cong1Hanqing He2Jianwei Wang3School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, ChinaSchool of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, ChinaSchool of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, ChinaSchool of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, ChinaAbstract. GSDME contains a pore-forming domain at its N-terminal region to execute pyroptosis. Our previous study has reported that forced expression of Gsdme impairs the reconstitution capacity of hematopoietic stem cells (HSCs). While, how GSDME-mediated pyroptosis regulates HSCs remains unknown. Here, we show that hematopoietic stem and progenitor cells are capable to undergo pyroptosis in response to cisplatin treatment and GSDME is one of the genes mediating such process. Gsdme−/− mice revealed no difference in the steady state of blood system while Gsdme−/− HSCs exhibited compromised reconstitution capacity due to increased apoptosis. Briefly, this study reveals that GSDME modulates HSC function by coordinating pyroptosis and apoptosis.http://journals.lww.com/10.1097/BS9.0000000000000064 |
| spellingShingle | Xiuxiu Yang Tingting Cong Hanqing He Jianwei Wang GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis Blood Science |
| title | GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis |
| title_full | GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis |
| title_fullStr | GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis |
| title_full_unstemmed | GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis |
| title_short | GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis |
| title_sort | gsdme maintains hematopoietic stem cells by balancing pyroptosis and apoptosis |
| url | http://journals.lww.com/10.1097/BS9.0000000000000064 |
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