Metabolic fate of tea polyphenols and their crosstalk with gut microbiota
Tea represents an abundant source of naturally occurring polyphenols. Tea polyphenols (TPs) have received growing attentions for its wide consumption in the world, and more importantly its pleiotropic bioeffects for human health. After ingestion, TPs may undergo absorption and phase II reaction in t...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2022-05-01
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| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021001312 |
| _version_ | 1797708076415975424 |
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| author | Meiyan Wang Jianying Li Ting Hu Hui Zhao |
| author_facet | Meiyan Wang Jianying Li Ting Hu Hui Zhao |
| author_sort | Meiyan Wang |
| collection | DOAJ |
| description | Tea represents an abundant source of naturally occurring polyphenols. Tea polyphenols (TPs) have received growing attentions for its wide consumption in the world, and more importantly its pleiotropic bioeffects for human health. After ingestion, TPs may undergo absorption and phase II reaction in the small intestine, and most undigested proportion would be submitted to the colon to interact with gut microbiota. Interactions between gut microbiota and TPs are bidirectional, including not only bacteria-mediated TPs metabolism, e.g., removal of gallic acid moiety and ring fission to release phenolic acid catabolites, but also TPs-based modification of bacterial profiles. Crosstalk between TPs and gut microbes may benefit for gut barrier function, for example, improvement of the intestinal permeability to alleviate inflammation. Moreover, by reshaping microbial composition and associated metabolites, TPs may exert a systemic protection on host metabolism, which contributes to improve certain chronic metabolic disorders. Given that, further understanding of the metabolic fate of TPs and interplay with gut microbiota as well as potential health-promoting effects are of great significance to development and application of tea and their polyphenolic components in the future as dietary supplements and/or functional ingredients in medical foods. |
| first_indexed | 2024-03-12T06:16:02Z |
| format | Article |
| id | doaj.art-ac5e2c7a0f7f438da0ccc457fc40072f |
| institution | Directory Open Access Journal |
| issn | 2213-4530 |
| language | English |
| last_indexed | 2024-03-12T06:16:02Z |
| publishDate | 2022-05-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj.art-ac5e2c7a0f7f438da0ccc457fc40072f2023-09-03T02:35:03ZengTsinghua University PressFood Science and Human Wellness2213-45302022-05-01113455466Metabolic fate of tea polyphenols and their crosstalk with gut microbiotaMeiyan Wang0Jianying Li1Ting Hu2Hui Zhao3Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China; Corresponding authors.Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, ChinaHubei Key Laboratory for EFGIR, Huanggang Normal University, Huanggang 438000, China; Corresponding authors.Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China; Corresponding authors.Tea represents an abundant source of naturally occurring polyphenols. Tea polyphenols (TPs) have received growing attentions for its wide consumption in the world, and more importantly its pleiotropic bioeffects for human health. After ingestion, TPs may undergo absorption and phase II reaction in the small intestine, and most undigested proportion would be submitted to the colon to interact with gut microbiota. Interactions between gut microbiota and TPs are bidirectional, including not only bacteria-mediated TPs metabolism, e.g., removal of gallic acid moiety and ring fission to release phenolic acid catabolites, but also TPs-based modification of bacterial profiles. Crosstalk between TPs and gut microbes may benefit for gut barrier function, for example, improvement of the intestinal permeability to alleviate inflammation. Moreover, by reshaping microbial composition and associated metabolites, TPs may exert a systemic protection on host metabolism, which contributes to improve certain chronic metabolic disorders. Given that, further understanding of the metabolic fate of TPs and interplay with gut microbiota as well as potential health-promoting effects are of great significance to development and application of tea and their polyphenolic components in the future as dietary supplements and/or functional ingredients in medical foods.http://www.sciencedirect.com/science/article/pii/S2213453021001312Tea polyphenolsMetabolismGut microbiotaBioeffects |
| spellingShingle | Meiyan Wang Jianying Li Ting Hu Hui Zhao Metabolic fate of tea polyphenols and their crosstalk with gut microbiota Food Science and Human Wellness Tea polyphenols Metabolism Gut microbiota Bioeffects |
| title | Metabolic fate of tea polyphenols and their crosstalk with gut microbiota |
| title_full | Metabolic fate of tea polyphenols and their crosstalk with gut microbiota |
| title_fullStr | Metabolic fate of tea polyphenols and their crosstalk with gut microbiota |
| title_full_unstemmed | Metabolic fate of tea polyphenols and their crosstalk with gut microbiota |
| title_short | Metabolic fate of tea polyphenols and their crosstalk with gut microbiota |
| title_sort | metabolic fate of tea polyphenols and their crosstalk with gut microbiota |
| topic | Tea polyphenols Metabolism Gut microbiota Bioeffects |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021001312 |
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