Endogenous MMTV proviruses induce susceptibility to both viral and bacterial pathogens.
Most inbred mice carry germline proviruses of the retrovirus, mouse mammary tumor virus (MMTV) (called Mtvs), which have multiple replication defects. A BALB/c congenic mouse strain lacking all endogenous Mtvs (Mtv-null) was resistant to MMTV oral and intraperitoneal infection and tumorigenesis comp...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2006-12-01
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| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.0020128 |
| _version_ | 1818734948919541760 |
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| author | Sanchita Bhadra Mary M Lozano Shelley M Payne Jaquelin P Dudley |
| author_facet | Sanchita Bhadra Mary M Lozano Shelley M Payne Jaquelin P Dudley |
| author_sort | Sanchita Bhadra |
| collection | DOAJ |
| description | Most inbred mice carry germline proviruses of the retrovirus, mouse mammary tumor virus (MMTV) (called Mtvs), which have multiple replication defects. A BALB/c congenic mouse strain lacking all endogenous Mtvs (Mtv-null) was resistant to MMTV oral and intraperitoneal infection and tumorigenesis compared to wild-type BALB/c mice. Infection of Mtv-null mice with an MMTV-related retrovirus, type B leukemogenic virus, also resulted in severely reduced viral loads and failure to induce T-cell lymphomas, indicating that resistance is not dependent on expression of a superantigen (Sag) encoded by exogenous MMTV. Resistance to MMTV in Mtv-null animals was not due to neutralizing antibodies. Further, Mtv-null mice were resistant to rapid mortality induced by intragastric inoculation of the Gram-negative bacterium, Vibrio cholerae, but susceptibility to Salmonella typhimurium was not significantly different from BALB/c mice. Susceptibility to both MMTV and V. cholerae was reconstituted by the presence of any one of three endogenous Mtvs located on different chromosomes and was associated with increased pathogen load. One of these endogenous proviruses is known to encode only Sag. Therefore, Mtv-encoded Sag appears to provide a unique genetic susceptibility to specific viruses and bacteria. Since human endogenous retroviruses also encode Sags, these studies have broad implications for pathogen-induced responses in mice and humans. |
| first_indexed | 2024-12-18T00:13:29Z |
| format | Article |
| id | doaj.art-ac5e75d6f5214270ac2391acc2753d64 |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-12-18T00:13:29Z |
| publishDate | 2006-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-ac5e75d6f5214270ac2391acc2753d642022-12-21T21:27:36ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742006-12-01212e12810.1371/journal.ppat.0020128Endogenous MMTV proviruses induce susceptibility to both viral and bacterial pathogens.Sanchita BhadraMary M LozanoShelley M PayneJaquelin P DudleyMost inbred mice carry germline proviruses of the retrovirus, mouse mammary tumor virus (MMTV) (called Mtvs), which have multiple replication defects. A BALB/c congenic mouse strain lacking all endogenous Mtvs (Mtv-null) was resistant to MMTV oral and intraperitoneal infection and tumorigenesis compared to wild-type BALB/c mice. Infection of Mtv-null mice with an MMTV-related retrovirus, type B leukemogenic virus, also resulted in severely reduced viral loads and failure to induce T-cell lymphomas, indicating that resistance is not dependent on expression of a superantigen (Sag) encoded by exogenous MMTV. Resistance to MMTV in Mtv-null animals was not due to neutralizing antibodies. Further, Mtv-null mice were resistant to rapid mortality induced by intragastric inoculation of the Gram-negative bacterium, Vibrio cholerae, but susceptibility to Salmonella typhimurium was not significantly different from BALB/c mice. Susceptibility to both MMTV and V. cholerae was reconstituted by the presence of any one of three endogenous Mtvs located on different chromosomes and was associated with increased pathogen load. One of these endogenous proviruses is known to encode only Sag. Therefore, Mtv-encoded Sag appears to provide a unique genetic susceptibility to specific viruses and bacteria. Since human endogenous retroviruses also encode Sags, these studies have broad implications for pathogen-induced responses in mice and humans.https://doi.org/10.1371/journal.ppat.0020128 |
| spellingShingle | Sanchita Bhadra Mary M Lozano Shelley M Payne Jaquelin P Dudley Endogenous MMTV proviruses induce susceptibility to both viral and bacterial pathogens. PLoS Pathogens |
| title | Endogenous MMTV proviruses induce susceptibility to both viral and bacterial pathogens. |
| title_full | Endogenous MMTV proviruses induce susceptibility to both viral and bacterial pathogens. |
| title_fullStr | Endogenous MMTV proviruses induce susceptibility to both viral and bacterial pathogens. |
| title_full_unstemmed | Endogenous MMTV proviruses induce susceptibility to both viral and bacterial pathogens. |
| title_short | Endogenous MMTV proviruses induce susceptibility to both viral and bacterial pathogens. |
| title_sort | endogenous mmtv proviruses induce susceptibility to both viral and bacterial pathogens |
| url | https://doi.org/10.1371/journal.ppat.0020128 |
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