Pneumocystis pneumonia in COVID-19 patients: A comprehensive review
The admitted patients of intensive care units with coronavirus disease 2019 (COVID-19) meet the challenges of subsequent infections. Opportunistic fungal infections such as Pneumocystis pneumonia (PCP) are among the important factors in the context of COVID-19 patients affecting illness severity and...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023008253 |
| _version_ | 1811161709292814336 |
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| author | Elahe Sasani Fares Bahrami Mohammadreza Salehi Farzad Aala Ronak Bakhtiari Alireza Abdollahi Bahareh Bashardoust Mahsa Abdorahimi Sadegh Khodavaisy |
| author_facet | Elahe Sasani Fares Bahrami Mohammadreza Salehi Farzad Aala Ronak Bakhtiari Alireza Abdollahi Bahareh Bashardoust Mahsa Abdorahimi Sadegh Khodavaisy |
| author_sort | Elahe Sasani |
| collection | DOAJ |
| description | The admitted patients of intensive care units with coronavirus disease 2019 (COVID-19) meet the challenges of subsequent infections. Opportunistic fungal infections such as Pneumocystis pneumonia (PCP) are among the important factors in the context of COVID-19 patients affecting illness severity and mortality. We reviewed the literature on COVID-19 patients with PCP to identify features of this infection. Although studies confirmed at least the presence of one immunosuppressive condition in half of PCP patients, this disease can also occur in immunocompetent patients who developed the immunosuppressive condition during Covid-19 treatment. The major risk factors associated with COVID-19 patients with PCP can be considered low lymphocyte counts and corticosteroid therapy. Diagnostic and treatment options are complicated by the overlapping clinical and radiologic characteristics of PCP and COVID-19 pneumonia. Therefore, physicians should comprehensively evaluate high-risk patients for PCP prophylaxis. |
| first_indexed | 2024-04-10T06:19:48Z |
| format | Article |
| id | doaj.art-ac5ecb55b82b4084814167c1c9cc7442 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-10T06:19:48Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-ac5ecb55b82b4084814167c1c9cc74422023-03-02T05:02:17ZengElsevierHeliyon2405-84402023-02-0192e13618Pneumocystis pneumonia in COVID-19 patients: A comprehensive reviewElahe Sasani0Fares Bahrami1Mohammadreza Salehi2Farzad Aala3Ronak Bakhtiari4Alireza Abdollahi5Bahareh Bashardoust6Mahsa Abdorahimi7Sadegh Khodavaisy8Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, IranZoonoses Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran; Department of Parasitology and Mycology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, IranResearch center for antibiotic stewardship and antimicrobial resistance, Tehran University of Medical Sciences, Tehran, Iran; Department of Infectious Diseases and Tropical Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IranDepartment of Parasitology and Mycology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, IranDepartment of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranDepartment of Pathology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IranDepartment of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranDepartment of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, IranZoonoses Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran; Research center for antibiotic stewardship and antimicrobial resistance, Tehran University of Medical Sciences, Tehran, Iran; Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Corresponding author.The admitted patients of intensive care units with coronavirus disease 2019 (COVID-19) meet the challenges of subsequent infections. Opportunistic fungal infections such as Pneumocystis pneumonia (PCP) are among the important factors in the context of COVID-19 patients affecting illness severity and mortality. We reviewed the literature on COVID-19 patients with PCP to identify features of this infection. Although studies confirmed at least the presence of one immunosuppressive condition in half of PCP patients, this disease can also occur in immunocompetent patients who developed the immunosuppressive condition during Covid-19 treatment. The major risk factors associated with COVID-19 patients with PCP can be considered low lymphocyte counts and corticosteroid therapy. Diagnostic and treatment options are complicated by the overlapping clinical and radiologic characteristics of PCP and COVID-19 pneumonia. Therefore, physicians should comprehensively evaluate high-risk patients for PCP prophylaxis.http://www.sciencedirect.com/science/article/pii/S2405844023008253Pneumocystosis pneumoniaCOVID-19SARS-CoV-2 |
| spellingShingle | Elahe Sasani Fares Bahrami Mohammadreza Salehi Farzad Aala Ronak Bakhtiari Alireza Abdollahi Bahareh Bashardoust Mahsa Abdorahimi Sadegh Khodavaisy Pneumocystis pneumonia in COVID-19 patients: A comprehensive review Heliyon Pneumocystosis pneumonia COVID-19 SARS-CoV-2 |
| title | Pneumocystis pneumonia in COVID-19 patients: A comprehensive review |
| title_full | Pneumocystis pneumonia in COVID-19 patients: A comprehensive review |
| title_fullStr | Pneumocystis pneumonia in COVID-19 patients: A comprehensive review |
| title_full_unstemmed | Pneumocystis pneumonia in COVID-19 patients: A comprehensive review |
| title_short | Pneumocystis pneumonia in COVID-19 patients: A comprehensive review |
| title_sort | pneumocystis pneumonia in covid 19 patients a comprehensive review |
| topic | Pneumocystosis pneumonia COVID-19 SARS-CoV-2 |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023008253 |
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