The Specific Binding and Promotion Effect of Azoles on Human Aldo-Keto Reductase 7A2

The Specific Binding and Promotion Effect of Azoles on Human Aldo-Keto Reductase 7A2

Human AKR 7A2 broadly participates in the metabolism of a number of exogenous and endogenous compounds. Azoles are a class of clinically widely used antifungal drugs, which are usually metabolized by CYP 3A4, CYP2C19, and CYP1A1, etc. in vivo. The azole–protein interactions that human AKR7A2 partici...

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Bibliographic Details
Main Authors: Wanying Wu, Tianqing Jiang, Haihui Lin, Chao Chen, Lingling Wang, Jikai Wen, Jun Wu, Yiqun Deng
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Metabolites
Subjects:
azoles
AKR7A2
AFAR
docking
drug–protein interactions
Online Access:https://www.mdpi.com/2218-1989/13/5/601

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