Delayed neuropsychiatric sequelae due to long-term effects of carbon monoxide poisoning in Ethiopia: A case report
Background: One emergency that occurs frequently and has high morbidity is carbon monoxide poisoning. After a time of lucidity, some victims who recover from the incident of acute carbon monoxide exposure may later suffer delayed neuropsychiatric sequelae (DNS), which can include cognitive impairmen...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
|
| Series: | Toxicology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750023000732 |
| _version_ | 1827580222259593216 |
|---|---|
| author | Belayneh Dessie Kassa Aklog Almaw Yigzaw Yoseph Gebremedhin Kassie Mulugeta Wondimu Kedimu Yihun Fenta Mekuanint Natnael Moges |
| author_facet | Belayneh Dessie Kassa Aklog Almaw Yigzaw Yoseph Gebremedhin Kassie Mulugeta Wondimu Kedimu Yihun Fenta Mekuanint Natnael Moges |
| author_sort | Belayneh Dessie Kassa |
| collection | DOAJ |
| description | Background: One emergency that occurs frequently and has high morbidity is carbon monoxide poisoning. After a time of lucidity, some victims who recover from the incident of acute carbon monoxide exposure may later suffer delayed neuropsychiatric sequelae (DNS), which can include cognitive impairments, a wide range of neurological abnormalities, and affective disorders. Below, we report the first documented incident of DNS after carbon monoxide poisoning in Ethiopia. Case presentation: A 40-year-old male patient who developed a coma after he was exposed to burning charcoal in a closed room was admitted to Debre Tabor Comprehensive Specialized Hospital in the northwest region of Ethiopia. He stayed for 12 days during his first admission and was discharged with improvement. One month after discharge, he developed delayed neuropsychiatric sequelae, which manifested as bizarre behavior, being unable to walk unsupported, loss of concentration, and failure to control urine and feces. Brain MRI showed bilateral periventricular and frontoparietal deep white matter subcortical abnormal T1 and T2 prolongation with no restriction of diffusivity, possibly due to demyelinating disorders. He was managed with fluid therapy, benzhexol, risperidone, and rehabilitation therapy. He stayed for two weeks in our hospital and was discharged with improvement. Conclusion: Despite the paucity of delayed neuropsychiatric sequelae from carbon monoxide poisoning, physicians should be highly suspicious in the right situations. The precise mechanisms of delayed toxic effects, prevention measures, and treatment modalities have not yet been determined; therefore, more research and attention are required. |
| first_indexed | 2024-03-08T22:15:28Z |
| format | Article |
| id | doaj.art-ac61822ca800444499b3a273c8c4275c |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-03-08T22:15:28Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-ac61822ca800444499b3a273c8c4275c2023-12-19T04:16:54ZengElsevierToxicology Reports2214-75002023-12-01113639Delayed neuropsychiatric sequelae due to long-term effects of carbon monoxide poisoning in Ethiopia: A case reportBelayneh Dessie Kassa0Aklog Almaw Yigzaw1Yoseph Gebremedhin Kassie2Mulugeta Wondimu Kedimu3Yihun Fenta Mekuanint4Natnael Moges5Department of Emergency and Critical Care Medicine, Debre Tabor University, Debre Tabor, Ethiopia; Correspondence to: Debre Tabor University, Debre Tabor, Ethiopia.Department of Internal Medicine, Debre Tabor University, Debre Tabor, EthiopiaDepartment of Internal Medicine, Debre Tabor Comprehensive Specialized Hospital, Debre Tabor, EthiopiaDepartment of Surgery, Debre Tabor University, Debre Tabor, EthiopiaDepartment of Radiology, Debre Tabor Comprehensive Specialized Hospital, Debre Tabor, EthiopiaDepartment of Pediatrics and Child Health Nursing, Debre Tabor University, Debre Tabor, EthiopiaBackground: One emergency that occurs frequently and has high morbidity is carbon monoxide poisoning. After a time of lucidity, some victims who recover from the incident of acute carbon monoxide exposure may later suffer delayed neuropsychiatric sequelae (DNS), which can include cognitive impairments, a wide range of neurological abnormalities, and affective disorders. Below, we report the first documented incident of DNS after carbon monoxide poisoning in Ethiopia. Case presentation: A 40-year-old male patient who developed a coma after he was exposed to burning charcoal in a closed room was admitted to Debre Tabor Comprehensive Specialized Hospital in the northwest region of Ethiopia. He stayed for 12 days during his first admission and was discharged with improvement. One month after discharge, he developed delayed neuropsychiatric sequelae, which manifested as bizarre behavior, being unable to walk unsupported, loss of concentration, and failure to control urine and feces. Brain MRI showed bilateral periventricular and frontoparietal deep white matter subcortical abnormal T1 and T2 prolongation with no restriction of diffusivity, possibly due to demyelinating disorders. He was managed with fluid therapy, benzhexol, risperidone, and rehabilitation therapy. He stayed for two weeks in our hospital and was discharged with improvement. Conclusion: Despite the paucity of delayed neuropsychiatric sequelae from carbon monoxide poisoning, physicians should be highly suspicious in the right situations. The precise mechanisms of delayed toxic effects, prevention measures, and treatment modalities have not yet been determined; therefore, more research and attention are required.http://www.sciencedirect.com/science/article/pii/S2214750023000732EthiopiaDelayed neuropsychiatric sequelaeCarbon monoxide poisoning |
| spellingShingle | Belayneh Dessie Kassa Aklog Almaw Yigzaw Yoseph Gebremedhin Kassie Mulugeta Wondimu Kedimu Yihun Fenta Mekuanint Natnael Moges Delayed neuropsychiatric sequelae due to long-term effects of carbon monoxide poisoning in Ethiopia: A case report Toxicology Reports Ethiopia Delayed neuropsychiatric sequelae Carbon monoxide poisoning |
| title | Delayed neuropsychiatric sequelae due to long-term effects of carbon monoxide poisoning in Ethiopia: A case report |
| title_full | Delayed neuropsychiatric sequelae due to long-term effects of carbon monoxide poisoning in Ethiopia: A case report |
| title_fullStr | Delayed neuropsychiatric sequelae due to long-term effects of carbon monoxide poisoning in Ethiopia: A case report |
| title_full_unstemmed | Delayed neuropsychiatric sequelae due to long-term effects of carbon monoxide poisoning in Ethiopia: A case report |
| title_short | Delayed neuropsychiatric sequelae due to long-term effects of carbon monoxide poisoning in Ethiopia: A case report |
| title_sort | delayed neuropsychiatric sequelae due to long term effects of carbon monoxide poisoning in ethiopia a case report |
| topic | Ethiopia Delayed neuropsychiatric sequelae Carbon monoxide poisoning |
| url | http://www.sciencedirect.com/science/article/pii/S2214750023000732 |
| work_keys_str_mv | AT belaynehdessiekassa delayedneuropsychiatricsequelaeduetolongtermeffectsofcarbonmonoxidepoisoninginethiopiaacasereport AT aklogalmawyigzaw delayedneuropsychiatricsequelaeduetolongtermeffectsofcarbonmonoxidepoisoninginethiopiaacasereport AT yosephgebremedhinkassie delayedneuropsychiatricsequelaeduetolongtermeffectsofcarbonmonoxidepoisoninginethiopiaacasereport AT mulugetawondimukedimu delayedneuropsychiatricsequelaeduetolongtermeffectsofcarbonmonoxidepoisoninginethiopiaacasereport AT yihunfentamekuanint delayedneuropsychiatricsequelaeduetolongtermeffectsofcarbonmonoxidepoisoninginethiopiaacasereport AT natnaelmoges delayedneuropsychiatricsequelaeduetolongtermeffectsofcarbonmonoxidepoisoninginethiopiaacasereport |