Metabolic frailty in malnourished heart failure patients
Muscular wasting (MW) and cardiac cachexia (CC) are often present in patients with chronic heart failure (HF). Aim: To identify whether MW and CC are due to malnutrition or impairment of protein metabolism in HF patients. Material and Method: In 78 clinically stable HF patients (NYHA class II-III),...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2016-02-01
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| Series: | Monaldi Archives for Chest Disease |
| Subjects: | |
| Online Access: | https://www.monaldi-archives.org/index.php/macd/article/view/461 |
| _version_ | 1818129709095976960 |
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| author | Alessandra Gualco Cristina Opasich Silvia Brazzo Franco Cobelli Evasio Pasini Ornella Pastoris Roberto Aquilani |
| author_facet | Alessandra Gualco Cristina Opasich Silvia Brazzo Franco Cobelli Evasio Pasini Ornella Pastoris Roberto Aquilani |
| author_sort | Alessandra Gualco |
| collection | DOAJ |
| description | Muscular wasting (MW) and cardiac cachexia (CC) are often present in patients with chronic heart failure (HF). Aim: To identify whether MW and CC are due to malnutrition or impairment of protein metabolism in HF patients. Material and Method: In 78 clinically stable HF patients (NYHA class II-III), aged from 32 to 89 years, we measured anthropometrical parameters and nutritional habits. In the identified 35 malnourished patients, we also measured: insulin resistance, gluconeogenetic amino acids blood concentration and nitrogen balance. Results: Seventy-five patients had eating-related symptoms. However we found significant nutritional impairment in 35 patients only. In addition, these 35 patients had: 1) significant increase of blood Alanine independently from both presence of insulin resistance or food intake reduction and 2) positive nitrogen balance. Conclusion: Food intake is not impaired in CHF patients. In spite of normal food intake, 35 of 78 patients had nutritional impairment with reduced anthropometric parameters and increased blood Alanine. These findings show alteration of proteins metabolism with proteolysis. We believe that specific physical training with nutritional supplement can be an additional therapy able to prevent protein disarrangement in CHF patients. |
| first_indexed | 2024-12-11T07:53:27Z |
| format | Article |
| id | doaj.art-ac63361ef40945bd81716794e4fada3d |
| institution | Directory Open Access Journal |
| issn | 1122-0643 2532-5264 |
| language | English |
| last_indexed | 2024-12-11T07:53:27Z |
| publishDate | 2016-02-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Monaldi Archives for Chest Disease |
| spelling | doaj.art-ac63361ef40945bd81716794e4fada3d2022-12-22T01:15:17ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642016-02-0168210.4081/monaldi.2007.461Metabolic frailty in malnourished heart failure patientsAlessandra Gualco0Cristina Opasich1Silvia Brazzo2Franco Cobelli3Evasio Pasini4Ornella Pastoris5Roberto Aquilani6Unità Operativa Riabilitativa Cardiologica, Istituto di Gussago Lumezzane (BS)Unità Operativa Riabilitativa Cardiologica, Istituto di Gussago Lumezzane (BS)Unità Operativa Riabilitativa Cardiologica, Istituto di Gussago Lumezzane (BS)Unità Operativa Riabilitativa Cardiologica, Istituto di Gussago Lumezzane (BS)Unità Operativa Riabilitativa Cardiologica, Istituto di Gussago Lumezzane (BS)Dipartimento di Scienze Fisiologiche-Farmacologiche Cellulari-Molecolari, Sezione di Farmacologia e Biotecnologie Farmacologiche, Università degli Studi di PaviaServizio Mebabolico Nutrizionale, Istituto di Montescano (PV)Muscular wasting (MW) and cardiac cachexia (CC) are often present in patients with chronic heart failure (HF). Aim: To identify whether MW and CC are due to malnutrition or impairment of protein metabolism in HF patients. Material and Method: In 78 clinically stable HF patients (NYHA class II-III), aged from 32 to 89 years, we measured anthropometrical parameters and nutritional habits. In the identified 35 malnourished patients, we also measured: insulin resistance, gluconeogenetic amino acids blood concentration and nitrogen balance. Results: Seventy-five patients had eating-related symptoms. However we found significant nutritional impairment in 35 patients only. In addition, these 35 patients had: 1) significant increase of blood Alanine independently from both presence of insulin resistance or food intake reduction and 2) positive nitrogen balance. Conclusion: Food intake is not impaired in CHF patients. In spite of normal food intake, 35 of 78 patients had nutritional impairment with reduced anthropometric parameters and increased blood Alanine. These findings show alteration of proteins metabolism with proteolysis. We believe that specific physical training with nutritional supplement can be an additional therapy able to prevent protein disarrangement in CHF patients.https://www.monaldi-archives.org/index.php/macd/article/view/461cachexiamusclenutritionheart failure |
| spellingShingle | Alessandra Gualco Cristina Opasich Silvia Brazzo Franco Cobelli Evasio Pasini Ornella Pastoris Roberto Aquilani Metabolic frailty in malnourished heart failure patients Monaldi Archives for Chest Disease cachexia muscle nutrition heart failure |
| title | Metabolic frailty in malnourished heart failure patients |
| title_full | Metabolic frailty in malnourished heart failure patients |
| title_fullStr | Metabolic frailty in malnourished heart failure patients |
| title_full_unstemmed | Metabolic frailty in malnourished heart failure patients |
| title_short | Metabolic frailty in malnourished heart failure patients |
| title_sort | metabolic frailty in malnourished heart failure patients |
| topic | cachexia muscle nutrition heart failure |
| url | https://www.monaldi-archives.org/index.php/macd/article/view/461 |
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