Symptomatic bone marrow lesions induced by reduced bone mineral density in middle-aged women: a cross-sectional Japanese population study
Abstract Background The etiology of bone marrow lesions (BMLs) without knee osteoarthritis (KOA) and their association with bone fragility are unclear. We aimed to investigate the association between BMLs, bone mineral density (BMD), and bone markers in women without radiographic evidence of KOA. Me...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-05-01
|
| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13075-019-1900-4 |
| _version_ | 1811294939646001152 |
|---|---|
| author | Seiya Ota Daisuke Chiba Eiji Sasaki Gentaro Kumagai Yuji Yamamoto Shigeyuki Nakaji Eiichi Tsuda Yasuyuki Ishibashi |
| author_facet | Seiya Ota Daisuke Chiba Eiji Sasaki Gentaro Kumagai Yuji Yamamoto Shigeyuki Nakaji Eiichi Tsuda Yasuyuki Ishibashi |
| author_sort | Seiya Ota |
| collection | DOAJ |
| description | Abstract Background The etiology of bone marrow lesions (BMLs) without knee osteoarthritis (KOA) and their association with bone fragility are unclear. We aimed to investigate the association between BMLs, bone mineral density (BMD), and bone markers in women without radiographic evidence of KOA. Methods This single-center cross-sectional study in a Japanese population included 266 women without radiographic evidence of KOA, which was defined as a Kellgren-Lawrence grade < 2. All participants underwent coronal and sagittal T2-weighted fat-suppressed magnetic resonance imaging of their right knee. BML severity was scored according to the Whole-Organ MRI Scoring method. BMD was measured by dual-energy X-ray absorptiometry of the forearm. Levels of bone markers (bone-alkaline phosphatase [BAP], type I procollagen N-terminal propeptide [PINP], cross-linked N-telopeptide of type I collagen [NTx], and tartrate-resistant acid phosphatase-5b [TRACP-5b]), pentosidine, and homocysteine were assessed in the serum. Knee symptoms were evaluated on the basis of the Knee injury and Osteoarthritis and Outcome Score (KOOS). Participants were divided into symptomatic knee and asymptomatic knee groups on the basis of their KOOS according to the classification criteria for early KOA. Multiple linear regression analysis was performed to evaluate the relationship between BMLs, BMD, and bone markers. Results The prevalence of BML was 35.3%. Age and some bone marker levels (BAP, PINP, NTx, and TRACP-5b) were higher, and all KOOS subscale scores and BMD were lower in participants with BMLs than in those without BMLs. On multiple linear regression analysis, BMD was negatively associated with BMLs (p = 0.014) in participants with symptomatic knees. There was no such association in participants with asymptomatic knees (p = 0.918). Among the bone markers, BAP (p = 0.006) and PINP (p = 0.043) were positively associated with BMLs in participants with symptomatic knees, while BAP (p = 0.038) and TRACP-5b (p = 0.011) were positively associated with BMLs in participants with asymptomatic knees. Conclusions In symptomatic Japanese women without radiographic evidence of KOA, BMD is negatively associated and some bone markers are positively associated with BMLs after adjustment for age and BMI. Thus, maintaining systemic bone metabolism could contribute to BML prevention in patients with pre-radiographic KOA. |
| first_indexed | 2024-04-13T05:24:55Z |
| format | Article |
| id | doaj.art-ac642ee8f70c44e3a4a7ea77c79f13f0 |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-04-13T05:24:55Z |
| publishDate | 2019-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-ac642ee8f70c44e3a4a7ea77c79f13f02022-12-22T03:00:37ZengBMCArthritis Research & Therapy1478-63622019-05-012111910.1186/s13075-019-1900-4Symptomatic bone marrow lesions induced by reduced bone mineral density in middle-aged women: a cross-sectional Japanese population studySeiya Ota0Daisuke Chiba1Eiji Sasaki2Gentaro Kumagai3Yuji Yamamoto4Shigeyuki Nakaji5Eiichi Tsuda6Yasuyuki Ishibashi7Department of Orthopaedic Surgery, Hirosaki University Graduate School of MedicineDepartment of Orthopaedic Surgery, Hirosaki University Graduate School of MedicineDepartment of Orthopaedic Surgery, Hirosaki University Graduate School of MedicineDepartment of Orthopaedic Surgery, Hirosaki University Graduate School of MedicineDepartment of Orthopaedic Surgery, Hirosaki University Graduate School of MedicineDepartment of Social Medicine, Hirosaki University Graduate School of MedicineDepartment of Rehabilitation Medicine, Hirosaki University Graduate School of MedicineDepartment of Orthopaedic Surgery, Hirosaki University Graduate School of MedicineAbstract Background The etiology of bone marrow lesions (BMLs) without knee osteoarthritis (KOA) and their association with bone fragility are unclear. We aimed to investigate the association between BMLs, bone mineral density (BMD), and bone markers in women without radiographic evidence of KOA. Methods This single-center cross-sectional study in a Japanese population included 266 women without radiographic evidence of KOA, which was defined as a Kellgren-Lawrence grade < 2. All participants underwent coronal and sagittal T2-weighted fat-suppressed magnetic resonance imaging of their right knee. BML severity was scored according to the Whole-Organ MRI Scoring method. BMD was measured by dual-energy X-ray absorptiometry of the forearm. Levels of bone markers (bone-alkaline phosphatase [BAP], type I procollagen N-terminal propeptide [PINP], cross-linked N-telopeptide of type I collagen [NTx], and tartrate-resistant acid phosphatase-5b [TRACP-5b]), pentosidine, and homocysteine were assessed in the serum. Knee symptoms were evaluated on the basis of the Knee injury and Osteoarthritis and Outcome Score (KOOS). Participants were divided into symptomatic knee and asymptomatic knee groups on the basis of their KOOS according to the classification criteria for early KOA. Multiple linear regression analysis was performed to evaluate the relationship between BMLs, BMD, and bone markers. Results The prevalence of BML was 35.3%. Age and some bone marker levels (BAP, PINP, NTx, and TRACP-5b) were higher, and all KOOS subscale scores and BMD were lower in participants with BMLs than in those without BMLs. On multiple linear regression analysis, BMD was negatively associated with BMLs (p = 0.014) in participants with symptomatic knees. There was no such association in participants with asymptomatic knees (p = 0.918). Among the bone markers, BAP (p = 0.006) and PINP (p = 0.043) were positively associated with BMLs in participants with symptomatic knees, while BAP (p = 0.038) and TRACP-5b (p = 0.011) were positively associated with BMLs in participants with asymptomatic knees. Conclusions In symptomatic Japanese women without radiographic evidence of KOA, BMD is negatively associated and some bone markers are positively associated with BMLs after adjustment for age and BMI. Thus, maintaining systemic bone metabolism could contribute to BML prevention in patients with pre-radiographic KOA.http://link.springer.com/article/10.1186/s13075-019-1900-4Bone marrow lesionBone mineral densityBone markersKnee osteoarthritis |
| spellingShingle | Seiya Ota Daisuke Chiba Eiji Sasaki Gentaro Kumagai Yuji Yamamoto Shigeyuki Nakaji Eiichi Tsuda Yasuyuki Ishibashi Symptomatic bone marrow lesions induced by reduced bone mineral density in middle-aged women: a cross-sectional Japanese population study Arthritis Research & Therapy Bone marrow lesion Bone mineral density Bone markers Knee osteoarthritis |
| title | Symptomatic bone marrow lesions induced by reduced bone mineral density in middle-aged women: a cross-sectional Japanese population study |
| title_full | Symptomatic bone marrow lesions induced by reduced bone mineral density in middle-aged women: a cross-sectional Japanese population study |
| title_fullStr | Symptomatic bone marrow lesions induced by reduced bone mineral density in middle-aged women: a cross-sectional Japanese population study |
| title_full_unstemmed | Symptomatic bone marrow lesions induced by reduced bone mineral density in middle-aged women: a cross-sectional Japanese population study |
| title_short | Symptomatic bone marrow lesions induced by reduced bone mineral density in middle-aged women: a cross-sectional Japanese population study |
| title_sort | symptomatic bone marrow lesions induced by reduced bone mineral density in middle aged women a cross sectional japanese population study |
| topic | Bone marrow lesion Bone mineral density Bone markers Knee osteoarthritis |
| url | http://link.springer.com/article/10.1186/s13075-019-1900-4 |
| work_keys_str_mv | AT seiyaota symptomaticbonemarrowlesionsinducedbyreducedbonemineraldensityinmiddleagedwomenacrosssectionaljapanesepopulationstudy AT daisukechiba symptomaticbonemarrowlesionsinducedbyreducedbonemineraldensityinmiddleagedwomenacrosssectionaljapanesepopulationstudy AT eijisasaki symptomaticbonemarrowlesionsinducedbyreducedbonemineraldensityinmiddleagedwomenacrosssectionaljapanesepopulationstudy AT gentarokumagai symptomaticbonemarrowlesionsinducedbyreducedbonemineraldensityinmiddleagedwomenacrosssectionaljapanesepopulationstudy AT yujiyamamoto symptomaticbonemarrowlesionsinducedbyreducedbonemineraldensityinmiddleagedwomenacrosssectionaljapanesepopulationstudy AT shigeyukinakaji symptomaticbonemarrowlesionsinducedbyreducedbonemineraldensityinmiddleagedwomenacrosssectionaljapanesepopulationstudy AT eiichitsuda symptomaticbonemarrowlesionsinducedbyreducedbonemineraldensityinmiddleagedwomenacrosssectionaljapanesepopulationstudy AT yasuyukiishibashi symptomaticbonemarrowlesionsinducedbyreducedbonemineraldensityinmiddleagedwomenacrosssectionaljapanesepopulationstudy |