Sustained virologic response improved the long-term health-related quality of life in patients with chronic hepatitis C: a prospective national study in China
Abstract Background To investigate the trends in health-related quality of life (HRQoL) among hepatitis C virus (HCV) patients and to assess the longitudinal impact of antiviral therapy on their well-being. Methods In this prospective multicenter observational study in adults with HCV infection, soc...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-023-08940-3 |
| _version_ | 1797355941345099776 |
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| author | Rui Huang Jia Shang Hong Chen Jun Li Qing Xie Jiajun Feng Lai Wei Huiying Rao |
| author_facet | Rui Huang Jia Shang Hong Chen Jun Li Qing Xie Jiajun Feng Lai Wei Huiying Rao |
| author_sort | Rui Huang |
| collection | DOAJ |
| description | Abstract Background To investigate the trends in health-related quality of life (HRQoL) among hepatitis C virus (HCV) patients and to assess the longitudinal impact of antiviral therapy on their well-being. Methods In this prospective multicenter observational study in adults with HCV infection, sociodemographic, clinical characteristics and EQ-5D questionnaires were collected. Generalized estimating equation (GEE) models were used to assess the associations between these variables and changes in HRQoL over time. Results 456 patients were included, with a median age of 46.5 (36.5–57.0) years, of which 262 (57.5%) were males and 44 (9.6%) had cirrhosis. 335 patients (73.5%) receiving antiviral therapy and 61.8% achieved sustained virologic response (SVR). The baseline EQ-5D utility and EQ-VAS were 0.916 ± 0.208 and 80.6 ± 13.0. In multivariable analysis of GEE estimation, achieving SVR24 was positively associated with EQ-5D utility (p = 0.000) and EQ-VAS (p = 0.000) over time. Age and income were shown to be significant predictors of EQ-5D utility, while gender, age and genotype were associated with EQ-VAS over time. Conclusions SVR improved long-term HRQoL in HCV patients in the first few years following viral clearance. Certain sociodemographic factors, such as gender, age, income as well as genotype, significantly influenced long-term changes in patients’ quality of life. Trial registration NCT01594554. Registration date: 09/05/2012. |
| first_indexed | 2024-03-08T14:19:26Z |
| format | Article |
| id | doaj.art-ac6451c3d0c1414aa141f16899c06b1f |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-08T14:19:26Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-ac6451c3d0c1414aa141f16899c06b1f2024-01-14T12:13:23ZengBMCBMC Infectious Diseases1471-23342024-01-0124111010.1186/s12879-023-08940-3Sustained virologic response improved the long-term health-related quality of life in patients with chronic hepatitis C: a prospective national study in ChinaRui Huang0Jia Shang1Hong Chen2Jun Li3Qing Xie4Jiajun Feng5Lai Wei6Huiying Rao7Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Peking University People’s Hospital, Peking University Hepatology Institute, Beijing International Cooperation Base for Science and Technology On NAFLD DiagnosisHenan Provincial People’s HospitalFirst Hospital of Lanzhou UniversityFirst Affiliated Hospital with Nanjing Medical UniversityMedical College, Ruijin Hospital, Shanghai Jiaotong UniversityDepartment of Marketing, School of Business, Renmin University of ChinaHepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, Tsinghua UniversityBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Peking University People’s Hospital, Peking University Hepatology Institute, Beijing International Cooperation Base for Science and Technology On NAFLD DiagnosisAbstract Background To investigate the trends in health-related quality of life (HRQoL) among hepatitis C virus (HCV) patients and to assess the longitudinal impact of antiviral therapy on their well-being. Methods In this prospective multicenter observational study in adults with HCV infection, sociodemographic, clinical characteristics and EQ-5D questionnaires were collected. Generalized estimating equation (GEE) models were used to assess the associations between these variables and changes in HRQoL over time. Results 456 patients were included, with a median age of 46.5 (36.5–57.0) years, of which 262 (57.5%) were males and 44 (9.6%) had cirrhosis. 335 patients (73.5%) receiving antiviral therapy and 61.8% achieved sustained virologic response (SVR). The baseline EQ-5D utility and EQ-VAS were 0.916 ± 0.208 and 80.6 ± 13.0. In multivariable analysis of GEE estimation, achieving SVR24 was positively associated with EQ-5D utility (p = 0.000) and EQ-VAS (p = 0.000) over time. Age and income were shown to be significant predictors of EQ-5D utility, while gender, age and genotype were associated with EQ-VAS over time. Conclusions SVR improved long-term HRQoL in HCV patients in the first few years following viral clearance. Certain sociodemographic factors, such as gender, age, income as well as genotype, significantly influenced long-term changes in patients’ quality of life. Trial registration NCT01594554. Registration date: 09/05/2012.https://doi.org/10.1186/s12879-023-08940-3Hepatitis C virus (HCV)Health-related quality of life (HRQoL)Sustained virological response (SVR) |
| spellingShingle | Rui Huang Jia Shang Hong Chen Jun Li Qing Xie Jiajun Feng Lai Wei Huiying Rao Sustained virologic response improved the long-term health-related quality of life in patients with chronic hepatitis C: a prospective national study in China BMC Infectious Diseases Hepatitis C virus (HCV) Health-related quality of life (HRQoL) Sustained virological response (SVR) |
| title | Sustained virologic response improved the long-term health-related quality of life in patients with chronic hepatitis C: a prospective national study in China |
| title_full | Sustained virologic response improved the long-term health-related quality of life in patients with chronic hepatitis C: a prospective national study in China |
| title_fullStr | Sustained virologic response improved the long-term health-related quality of life in patients with chronic hepatitis C: a prospective national study in China |
| title_full_unstemmed | Sustained virologic response improved the long-term health-related quality of life in patients with chronic hepatitis C: a prospective national study in China |
| title_short | Sustained virologic response improved the long-term health-related quality of life in patients with chronic hepatitis C: a prospective national study in China |
| title_sort | sustained virologic response improved the long term health related quality of life in patients with chronic hepatitis c a prospective national study in china |
| topic | Hepatitis C virus (HCV) Health-related quality of life (HRQoL) Sustained virological response (SVR) |
| url | https://doi.org/10.1186/s12879-023-08940-3 |
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