Targeting the Regulatory Subunit R2Alpha of Protein Kinase A in Human Glioblastoma through shRNA-Expressing Lentiviral Vectors

Targeting the Regulatory Subunit R2Alpha of Protein Kinase A in Human Glioblastoma through shRNA-Expressing Lentiviral Vectors

Glioblastoma is the most malignant and most common form of brain tumor, still today associated with a poor 14-months median survival from diagnosis. Protein kinase A, particularly its regulatory subunit R2Alpha, presents a typical intracellular distribution in glioblastoma cells compared to the heal...

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Bibliographic Details
Main Authors: Maira Zorzan, Claudia Del Vecchio, Stefania Vogiatzis, Elisa Saccon, Cristina Parolin, Giorgio Palù, Arianna Calistri, Carla Mucignat-Caretta
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Viruses
Subjects:
lentiviral vectors
glioblastoma
protein kinase A
brain tumor
short hairpin RNA
cAMP
Online Access:https://www.mdpi.com/1999-4915/13/7/1361

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