Evaluation of the Serum Levels of TNF-α and IL-8 in the Patients Undergoing Angiography
Introduction: Angiography is a safe cardiovascular technique for the diagnosis and treatment of cardiovascular disorders. The potential effects of angiography on the levels of cytokines are yet to be clarified completely. Interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-α) are important pro...
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| Format: | Article |
| Language: | English |
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Zabol University of Medical sciences
2022-03-01
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| Series: | International Journal of Basic Science in Medicine |
| Subjects: | |
| Online Access: | https://ijbsm.zbmu.ac.ir/PDF/ijbsm-7-11.pdf |
| _version_ | 1818491231891619840 |
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| author | Lida Zare Akram Eidi Mohammad Safarian Mohammad Kazemi Arababadi |
| author_facet | Lida Zare Akram Eidi Mohammad Safarian Mohammad Kazemi Arababadi |
| author_sort | Lida Zare |
| collection | DOAJ |
| description | Introduction: Angiography is a safe cardiovascular technique for the diagnosis and treatment of cardiovascular disorders. The potential effects of angiography on the levels of cytokines are yet to be clarified completely. Interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-α) are important pro-inflammatory cytokines that participate in the pathogenesis of artery stenosis. The aim of this study was to investigate the effects of angiography on the serum levels of IL-8 and TNF-α.Methods: Sixty participants in three groups, without, with one, and with more than one artery stenosis, were explored in this project. Serum levels of IL-8 and TNF-α were measured in the participants before and after angiography using the enzyme linked immunosorbent assay (ELISA) technique.Results: Serum levels of IL-8, but not TNF-α, significantly decreased following angiography from 61.45 (9.80-266.72) to 7.00 (3.82-17.85) pg/mL (P = 0.008) in participants without artery stenosis, from 79.40 (7.20-197.40) to 6.80 (3.85-29.50) pg/mL (P = 0.002) in participants with one artery stenosis, and from 91.25 (12.80-145.97) to 10.75 (6.97-49.82) pg/mL (P = 0.004) in participants with more than one artery stenosis. The X-ray dose had a moderate positive correlation with serum levels of TNF-α in patients with more than one artery stenosis (r = 0.584, P = 0.009). Serum levels of IL-8 and TNF-α were not different between male and female participants in none of the groups. Conclusion: Angiography may be a protective factor against inflammation by suppressing IL-8. |
| first_indexed | 2024-12-10T17:28:02Z |
| format | Article |
| id | doaj.art-ac664d969ade4be48aa38bf05e6efc39 |
| institution | Directory Open Access Journal |
| issn | 2476-664X |
| language | English |
| last_indexed | 2024-12-10T17:28:02Z |
| publishDate | 2022-03-01 |
| publisher | Zabol University of Medical sciences |
| record_format | Article |
| series | International Journal of Basic Science in Medicine |
| spelling | doaj.art-ac664d969ade4be48aa38bf05e6efc392022-12-22T01:39:48ZengZabol University of Medical sciencesInternational Journal of Basic Science in Medicine2476-664X2022-03-0171111410.34172/ijbsm.2022.03ijbsm-23542Evaluation of the Serum Levels of TNF-α and IL-8 in the Patients Undergoing AngiographyLida Zare0Akram Eidi1Mohammad Safarian2Mohammad Kazemi Arababadi3Department of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Cardiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, IranDepartment of Laboratory Sciences, Faculty of Paramedicine, Rafsanjan University of Medical Sciences, Rafsanjan, IranIntroduction: Angiography is a safe cardiovascular technique for the diagnosis and treatment of cardiovascular disorders. The potential effects of angiography on the levels of cytokines are yet to be clarified completely. Interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-α) are important pro-inflammatory cytokines that participate in the pathogenesis of artery stenosis. The aim of this study was to investigate the effects of angiography on the serum levels of IL-8 and TNF-α.Methods: Sixty participants in three groups, without, with one, and with more than one artery stenosis, were explored in this project. Serum levels of IL-8 and TNF-α were measured in the participants before and after angiography using the enzyme linked immunosorbent assay (ELISA) technique.Results: Serum levels of IL-8, but not TNF-α, significantly decreased following angiography from 61.45 (9.80-266.72) to 7.00 (3.82-17.85) pg/mL (P = 0.008) in participants without artery stenosis, from 79.40 (7.20-197.40) to 6.80 (3.85-29.50) pg/mL (P = 0.002) in participants with one artery stenosis, and from 91.25 (12.80-145.97) to 10.75 (6.97-49.82) pg/mL (P = 0.004) in participants with more than one artery stenosis. The X-ray dose had a moderate positive correlation with serum levels of TNF-α in patients with more than one artery stenosis (r = 0.584, P = 0.009). Serum levels of IL-8 and TNF-α were not different between male and female participants in none of the groups. Conclusion: Angiography may be a protective factor against inflammation by suppressing IL-8.https://ijbsm.zbmu.ac.ir/PDF/ijbsm-7-11.pdfartery stenosisangiographyx-raycytokineil-8tnf-a |
| spellingShingle | Lida Zare Akram Eidi Mohammad Safarian Mohammad Kazemi Arababadi Evaluation of the Serum Levels of TNF-α and IL-8 in the Patients Undergoing Angiography International Journal of Basic Science in Medicine artery stenosis angiography x-ray cytokine il-8 tnf-a |
| title | Evaluation of the Serum Levels of TNF-α and IL-8 in the Patients Undergoing Angiography |
| title_full | Evaluation of the Serum Levels of TNF-α and IL-8 in the Patients Undergoing Angiography |
| title_fullStr | Evaluation of the Serum Levels of TNF-α and IL-8 in the Patients Undergoing Angiography |
| title_full_unstemmed | Evaluation of the Serum Levels of TNF-α and IL-8 in the Patients Undergoing Angiography |
| title_short | Evaluation of the Serum Levels of TNF-α and IL-8 in the Patients Undergoing Angiography |
| title_sort | evaluation of the serum levels of tnf α and il 8 in the patients undergoing angiography |
| topic | artery stenosis angiography x-ray cytokine il-8 tnf-a |
| url | https://ijbsm.zbmu.ac.ir/PDF/ijbsm-7-11.pdf |
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