Development of Foot-and-Mouth Disease Virus-Neutralizing Monoclonal Antibodies Derived From Plasmablasts of Infected Cattle and Their Germline Gene Usage

Development of Foot-and-Mouth Disease Virus-Neutralizing Monoclonal Antibodies Derived From Plasmablasts of Infected Cattle and Their Germline Gene Usage

Cattle are susceptible to foot-and-mouth disease virus (FMDV), and neutralizing antibodies are critical for protection against FMDV infection in this species. However, more information is needed on the host specific antigenic structure recognized by the FMDV-specific monoclonal antibodies (mAbs) and...

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Bibliographic Details
Main Authors: Kun Li, Sheng Wang, Yimei Cao, Huifang Bao, Pinghua Li, Pu Sun, Xingwen Bai, Yuanfang Fu, Xueqing Ma, Jing Zhang, Dong Li, Yingli Chen, Xuerong Liu, Fanglan An, Faju Wu, Zengjun Lu, Zaixin Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
cattle
foot-and-mouth disease virus
broadly neutralizing antibodies
antigenic character
single B cell antibody
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02870/full

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