A conserved epitope in VAR2CSA is targeted by a cross-reactive antibody originating from Plasmodium vivax Duffy binding protein

A conserved epitope in VAR2CSA is targeted by a cross-reactive antibody originating from Plasmodium vivax Duffy binding protein

During Plasmodium falciparum infection in pregnancy, VAR2CSA is expressed on the surface of infected erythrocytes (IEs) and mediates their sequestration in the placenta. As a result, antibodies to VAR2CSA are largely restricted to women who were infected during pregnancy. However, we discovered that...

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Bibliographic Details
Main Authors: Uwa Iyamu, Daniel Ferrer Vinals, Bernard Tornyigah, Eliana Arango, Rakesh Bhat, Trixie Rae Adra, Simranjit Grewal, Kimberly Martin, Amanda Maestre, Michael Overduin, Bart Hazes, Stephanie K. Yanow
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
malaria
VAR2CSA
cross-reactivity
PvDBP
peptide
vaccine design
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1202276/full

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