Identification of CD8+ T cell infiltration-related genes and their prognostic values in cervical cancer
Cervical cancer is a female-specific cancer with relatively high morbidity and mortality. As known to all, immune cell infiltrations in the cancer microenvironment are closely related to the cancer diagnosis and prognosis. Here we revealed that the CD8+ T cell infiltration was significantly upregula...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1031643/full |
| _version_ | 1811192283876294656 |
|---|---|
| author | Xiaopeng Shen Chunguang Wang Meng Li Sufen Wang Yun Zhao Zhongxian Liu Guoping Zhu |
| author_facet | Xiaopeng Shen Chunguang Wang Meng Li Sufen Wang Yun Zhao Zhongxian Liu Guoping Zhu |
| author_sort | Xiaopeng Shen |
| collection | DOAJ |
| description | Cervical cancer is a female-specific cancer with relatively high morbidity and mortality. As known to all, immune cell infiltrations in the cancer microenvironment are closely related to the cancer diagnosis and prognosis. Here we revealed that the CD8+ T cell infiltration was significantly upregulated in cervical cancer versus normal cervix uteri samples. Through univariate and multivariate cox analyses, we discovered that the CD8+ T cell infiltration was the only independent beneficial factor for the prognosis of cervical cancer. To explore the genes associated with the CD8+ T cell infiltration in cervical cancer, we performed the WGCNA analysis on the differentially expressed genes (DEGs) of cervical cancer versus normal cervix uteri tissues. As a result, 231 DEGs were found to be associated with CD8+ T cell infiltration in cervical cancer. Subsequently, with the Cytoscape analysis, we identified 105 hub genes out of the 231 DEGs. To further explore the genes that might be responsible for the prognosis of cervical cancer, we performed a univariate cox analysis followed by a LASSO assay on the 105 hub genes and located four genes (IGSF6, TLR10, FCRL3, and IFI30) finally. The four genes could be applied to the prediction of the prognosis of cervical cancer, and relatively higher expression of these four genes predicted a better prognosis. These findings contributed to our understanding of the prognostic values of CD8+ T cell infiltration and its associated genes in cervical cancer and thus might benefit future immune-related therapies. |
| first_indexed | 2024-04-11T23:50:03Z |
| format | Article |
| id | doaj.art-ac6852bc5cfa4d699750c3695d705102 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T23:50:03Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-ac6852bc5cfa4d699750c3695d7051022022-12-22T03:56:30ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-10-011210.3389/fonc.2022.10316431031643Identification of CD8+ T cell infiltration-related genes and their prognostic values in cervical cancerXiaopeng Shen0Chunguang Wang1Meng Li2Sufen Wang3Yun Zhao4Zhongxian Liu5Guoping Zhu6College of Life Sciences, Anhui Normal University, Wuhu, Anhui, ChinaCollege of Life Sciences, Anhui Normal University, Wuhu, Anhui, ChinaCollege of Life Sciences, Anhui Normal University, Wuhu, Anhui, ChinaDepartment of Pathology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, ChinaCollege of Life Sciences, Anhui Normal University, Wuhu, Anhui, ChinaCollege of Life Sciences, Anhui Normal University, Wuhu, Anhui, ChinaCollege of Life Sciences, Anhui Normal University, Wuhu, Anhui, ChinaCervical cancer is a female-specific cancer with relatively high morbidity and mortality. As known to all, immune cell infiltrations in the cancer microenvironment are closely related to the cancer diagnosis and prognosis. Here we revealed that the CD8+ T cell infiltration was significantly upregulated in cervical cancer versus normal cervix uteri samples. Through univariate and multivariate cox analyses, we discovered that the CD8+ T cell infiltration was the only independent beneficial factor for the prognosis of cervical cancer. To explore the genes associated with the CD8+ T cell infiltration in cervical cancer, we performed the WGCNA analysis on the differentially expressed genes (DEGs) of cervical cancer versus normal cervix uteri tissues. As a result, 231 DEGs were found to be associated with CD8+ T cell infiltration in cervical cancer. Subsequently, with the Cytoscape analysis, we identified 105 hub genes out of the 231 DEGs. To further explore the genes that might be responsible for the prognosis of cervical cancer, we performed a univariate cox analysis followed by a LASSO assay on the 105 hub genes and located four genes (IGSF6, TLR10, FCRL3, and IFI30) finally. The four genes could be applied to the prediction of the prognosis of cervical cancer, and relatively higher expression of these four genes predicted a better prognosis. These findings contributed to our understanding of the prognostic values of CD8+ T cell infiltration and its associated genes in cervical cancer and thus might benefit future immune-related therapies.https://www.frontiersin.org/articles/10.3389/fonc.2022.1031643/fullCD8+ T cellscervical cancerprognosisIGSF6TLR10FCRL3 |
| spellingShingle | Xiaopeng Shen Chunguang Wang Meng Li Sufen Wang Yun Zhao Zhongxian Liu Guoping Zhu Identification of CD8+ T cell infiltration-related genes and their prognostic values in cervical cancer Frontiers in Oncology CD8+ T cells cervical cancer prognosis IGSF6 TLR10 FCRL3 |
| title | Identification of CD8+ T cell infiltration-related genes and their prognostic values in cervical cancer |
| title_full | Identification of CD8+ T cell infiltration-related genes and their prognostic values in cervical cancer |
| title_fullStr | Identification of CD8+ T cell infiltration-related genes and their prognostic values in cervical cancer |
| title_full_unstemmed | Identification of CD8+ T cell infiltration-related genes and their prognostic values in cervical cancer |
| title_short | Identification of CD8+ T cell infiltration-related genes and their prognostic values in cervical cancer |
| title_sort | identification of cd8 t cell infiltration related genes and their prognostic values in cervical cancer |
| topic | CD8+ T cells cervical cancer prognosis IGSF6 TLR10 FCRL3 |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1031643/full |
| work_keys_str_mv | AT xiaopengshen identificationofcd8tcellinfiltrationrelatedgenesandtheirprognosticvaluesincervicalcancer AT chunguangwang identificationofcd8tcellinfiltrationrelatedgenesandtheirprognosticvaluesincervicalcancer AT mengli identificationofcd8tcellinfiltrationrelatedgenesandtheirprognosticvaluesincervicalcancer AT sufenwang identificationofcd8tcellinfiltrationrelatedgenesandtheirprognosticvaluesincervicalcancer AT yunzhao identificationofcd8tcellinfiltrationrelatedgenesandtheirprognosticvaluesincervicalcancer AT zhongxianliu identificationofcd8tcellinfiltrationrelatedgenesandtheirprognosticvaluesincervicalcancer AT guopingzhu identificationofcd8tcellinfiltrationrelatedgenesandtheirprognosticvaluesincervicalcancer |