Optimization and Deoptimization of Codons in SARS‐CoV‐2 and Related Implications for Vaccine Development

Optimization and Deoptimization of Codons in SARS‐CoV‐2 and Related Implications for Vaccine Development

Abstract The spread of coronavirus disease 2019 (COVID‐19), caused by severe respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has progressed into a global pandemic. To date, thousands of genetic variants have been identified among SARS‐CoV‐2 isolates collected from patients. Sequence analysis reveal...

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Bibliographic Details
Main Authors: Xinkai Wu, Ke‐jia Shan, Fuwen Zan, Xiaolu Tang, Zhaohui Qian, Jian Lu
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Advanced Science
Subjects:
codon optimization
codon usage bias
SARS‐CoV‐2
spike protein
synonymous mutations
vaccine design
Online Access:https://doi.org/10.1002/advs.202205445

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