Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy
Inflammatory bowel disease (IBD) is a life-threatening organ dysfunction amplified by complex interactions between genetic, environmental, and immune factors. Sulfasalazine (Sul), an immunosuppressant, can potentially treat autoinflammation-induced disorders; however, clinical application of Sul is...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127522010887 |
| _version_ | 1828051380983562240 |
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| author | Sen Lin Haosen Zhao Chang Xu Peng Zhang Xifan Mei Dingwen Jiang |
| author_facet | Sen Lin Haosen Zhao Chang Xu Peng Zhang Xifan Mei Dingwen Jiang |
| author_sort | Sen Lin |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a life-threatening organ dysfunction amplified by complex interactions between genetic, environmental, and immune factors. Sulfasalazine (Sul), an immunosuppressant, can potentially treat autoinflammation-induced disorders; however, clinical application of Sul is hindered by its inability to be directly taken up by cells. To address this challenge, we developed Mn doped prussian blue nanozymes (MPBs) to directly deliver Sul for targeting reactive oxygen species (ROS)-enriched microenvironment. The artificial nanozyme (Sul-MPBs) exhibits reactive oxygen species (ROS)-scavenging properties against hydrogen peroxide (H2O2)-mediated mitochondrial dysfunction and possesses both catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)-like properties in vitro. Furthermore, it significantly enhances therapeutic effects in treating dextran sulfate sodium salt (DSS)-induced IBD via alleviating ROS-mediated inflammatory responses. This study demonstrates good biocompatibility and protective properties of this artificial nanozyme, thus potentially leading to a highly innovative and translational approach to treat IBD efficiently and safely. |
| first_indexed | 2024-04-10T19:37:58Z |
| format | Article |
| id | doaj.art-ac6ab6d0cbd042eeae939abf1bdb7294 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-10T19:37:58Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-ac6ab6d0cbd042eeae939abf1bdb72942023-01-30T04:12:00ZengElsevierMaterials & Design0264-12752023-01-01225111465Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategySen Lin0Haosen Zhao1Chang Xu2Peng Zhang3Xifan Mei4Dingwen Jiang5Department of Orthopedic, Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, China; Key Laboratory of Medical Tissue Engineering, Jinzhou Medical University, Jinzhou, China; Corresponding authors at: Department of Orthopedic, Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, China (S. Lin and X. Mei).Department of Orthopedic, Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, ChinaDepartment of Orthopedic, First Affiliated Hospital of Jinzhou Medical University, Jinzhou, ChinaKey Laboratory of Medical Tissue Engineering, Jinzhou Medical University, Jinzhou, ChinaDepartment of Orthopedic, Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, China; Key Laboratory of Medical Tissue Engineering, Jinzhou Medical University, Jinzhou, China; Corresponding authors at: Department of Orthopedic, Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, China (S. Lin and X. Mei).Department of Endocrinology, First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China; Corresponding authors at: Department of Orthopedic, Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, China (S. Lin and X. Mei).Inflammatory bowel disease (IBD) is a life-threatening organ dysfunction amplified by complex interactions between genetic, environmental, and immune factors. Sulfasalazine (Sul), an immunosuppressant, can potentially treat autoinflammation-induced disorders; however, clinical application of Sul is hindered by its inability to be directly taken up by cells. To address this challenge, we developed Mn doped prussian blue nanozymes (MPBs) to directly deliver Sul for targeting reactive oxygen species (ROS)-enriched microenvironment. The artificial nanozyme (Sul-MPBs) exhibits reactive oxygen species (ROS)-scavenging properties against hydrogen peroxide (H2O2)-mediated mitochondrial dysfunction and possesses both catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)-like properties in vitro. Furthermore, it significantly enhances therapeutic effects in treating dextran sulfate sodium salt (DSS)-induced IBD via alleviating ROS-mediated inflammatory responses. This study demonstrates good biocompatibility and protective properties of this artificial nanozyme, thus potentially leading to a highly innovative and translational approach to treat IBD efficiently and safely.http://www.sciencedirect.com/science/article/pii/S0264127522010887Inflammatory bowel diseaseSulfasalazineMn doped prussian blue nanoparticlesROSInflammation |
| spellingShingle | Sen Lin Haosen Zhao Chang Xu Peng Zhang Xifan Mei Dingwen Jiang Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy Materials & Design Inflammatory bowel disease Sulfasalazine Mn doped prussian blue nanoparticles ROS Inflammation |
| title | Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy |
| title_full | Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy |
| title_fullStr | Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy |
| title_full_unstemmed | Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy |
| title_short | Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy |
| title_sort | sulfasalazine loaded nanoparticles for efficient inflammatory bowel disease therapy via ros scavenging strategy |
| topic | Inflammatory bowel disease Sulfasalazine Mn doped prussian blue nanoparticles ROS Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S0264127522010887 |
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