Açaí (Euterpe oleracea Mart.) has anti-inflammatory potential through NLRP3-inflammasome modulation
There are several diseases, such as bipolar disorder, for example, where a chronic inflammation related to NLRP3 inflammasome is present. So, it is important to search for new anti-inflammatory agents. Açaí (Euterpe oleracea Mart.) is a Brazilian fruit with antioxidant and anti-inflammatory activiti...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-05-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619301525 |
| _version_ | 1818414151636090880 |
|---|---|
| author | Alencar Kolinski Machado Francine Carla Cadoná Charles Elias Assmann Ana Cristina Andreazza Marta Maria Medeiros Frescura Duarte Cátia dos Santos Branco Xinyang Zhou Diulie Valente de Souza Euler Esteves Ribeiro Ivana Beatrice Mânica da Cruz |
| author_facet | Alencar Kolinski Machado Francine Carla Cadoná Charles Elias Assmann Ana Cristina Andreazza Marta Maria Medeiros Frescura Duarte Cátia dos Santos Branco Xinyang Zhou Diulie Valente de Souza Euler Esteves Ribeiro Ivana Beatrice Mânica da Cruz |
| author_sort | Alencar Kolinski Machado |
| collection | DOAJ |
| description | There are several diseases, such as bipolar disorder, for example, where a chronic inflammation related to NLRP3 inflammasome is present. So, it is important to search for new anti-inflammatory agents. Açaí (Euterpe oleracea Mart.) is a Brazilian fruit with antioxidant and anti-inflammatory activities. However, the mechanism of açaí anti-inflammatory potential is still unclear. The objective of this study was to evaluate the anti-inflammatory effect of açaí extract and its mechanism. Macrophages were exposed to phytohemagglutinin to induce inflammation and treated with different concentrations of açaí extract. Cellular proliferation, cell cycle, oxidative metabolism parameters, inflammatory cytokines and NLRP3 have been assessed. 1 μg/mL of açaí extract was able to act as an antioxidant agent. Açaí extract decreased NLRP3 inflammasome levels and reduced pro-inflammatory cytokines. The extract caused cell cycle arresting and decreased proliferation. Obtained results suggest that açaí extract has anti-inflammatory effect and its mechanism of action involve NLRP3 inflammasome modulation. |
| first_indexed | 2024-12-14T11:14:32Z |
| format | Article |
| id | doaj.art-ac6ac19a505f49519f7258fd44bd0de9 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T11:14:32Z |
| publishDate | 2019-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-ac6ac19a505f49519f7258fd44bd0de92022-12-21T23:04:06ZengElsevierJournal of Functional Foods1756-46462019-05-0156364371Açaí (Euterpe oleracea Mart.) has anti-inflammatory potential through NLRP3-inflammasome modulationAlencar Kolinski Machado0Francine Carla Cadoná1Charles Elias Assmann2Ana Cristina Andreazza3Marta Maria Medeiros Frescura Duarte4Cátia dos Santos Branco5Xinyang Zhou6Diulie Valente de Souza7Euler Esteves Ribeiro8Ivana Beatrice Mânica da Cruz9Graduate Program in Nanosciences, Franciscan University, Santa Maria, RS, Brazil; Corresponding author at: Andradas’ Street, 1614, Building #04, Suite 216, Santa Maria, RS 97010-032, Brazil.Franciscan University, Santa Maria, RS, BrazilBiogenomics Laboratory, Department of Morphology, Health Science Center, Federal University of Santa Maria, Santa Maria, RS, BrazilDepartment of Pharmacology, University of Toronto, Toronto, ON, Canada; Centre for Addiction and Mental Health, Toronto, ON, CanadaLutheran University of Brazil, Santa Maria, RS, BrazilLaboratory of Oxidative Stress and Antioxidants, Biotechnology Institute, University of Caxias do Sul, Caxias do Sul, RS, BrazilDepartment of Pharmacology, University of Toronto, Toronto, ON, CanadaGraduate Program in Nanosciences, Franciscan University, Santa Maria, RS, BrazilBiogenomics Laboratory, Department of Morphology, Health Science Center, Federal University of Santa Maria, Santa Maria, RS, Brazil; Third Age Open University, University of Amazonas State, Manaus, AM, BrazilBiogenomics Laboratory, Department of Morphology, Health Science Center, Federal University of Santa Maria, Santa Maria, RS, Brazil; Graduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria, RS, BrazilThere are several diseases, such as bipolar disorder, for example, where a chronic inflammation related to NLRP3 inflammasome is present. So, it is important to search for new anti-inflammatory agents. Açaí (Euterpe oleracea Mart.) is a Brazilian fruit with antioxidant and anti-inflammatory activities. However, the mechanism of açaí anti-inflammatory potential is still unclear. The objective of this study was to evaluate the anti-inflammatory effect of açaí extract and its mechanism. Macrophages were exposed to phytohemagglutinin to induce inflammation and treated with different concentrations of açaí extract. Cellular proliferation, cell cycle, oxidative metabolism parameters, inflammatory cytokines and NLRP3 have been assessed. 1 μg/mL of açaí extract was able to act as an antioxidant agent. Açaí extract decreased NLRP3 inflammasome levels and reduced pro-inflammatory cytokines. The extract caused cell cycle arresting and decreased proliferation. Obtained results suggest that açaí extract has anti-inflammatory effect and its mechanism of action involve NLRP3 inflammasome modulation.http://www.sciencedirect.com/science/article/pii/S1756464619301525Chronic inflammatory responseNatural productCytokines |
| spellingShingle | Alencar Kolinski Machado Francine Carla Cadoná Charles Elias Assmann Ana Cristina Andreazza Marta Maria Medeiros Frescura Duarte Cátia dos Santos Branco Xinyang Zhou Diulie Valente de Souza Euler Esteves Ribeiro Ivana Beatrice Mânica da Cruz Açaí (Euterpe oleracea Mart.) has anti-inflammatory potential through NLRP3-inflammasome modulation Journal of Functional Foods Chronic inflammatory response Natural product Cytokines |
| title | Açaí (Euterpe oleracea Mart.) has anti-inflammatory potential through NLRP3-inflammasome modulation |
| title_full | Açaí (Euterpe oleracea Mart.) has anti-inflammatory potential through NLRP3-inflammasome modulation |
| title_fullStr | Açaí (Euterpe oleracea Mart.) has anti-inflammatory potential through NLRP3-inflammasome modulation |
| title_full_unstemmed | Açaí (Euterpe oleracea Mart.) has anti-inflammatory potential through NLRP3-inflammasome modulation |
| title_short | Açaí (Euterpe oleracea Mart.) has anti-inflammatory potential through NLRP3-inflammasome modulation |
| title_sort | acai euterpe oleracea mart has anti inflammatory potential through nlrp3 inflammasome modulation |
| topic | Chronic inflammatory response Natural product Cytokines |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619301525 |
| work_keys_str_mv | AT alencarkolinskimachado acaieuterpeoleraceamarthasantiinflammatorypotentialthroughnlrp3inflammasomemodulation AT francinecarlacadona acaieuterpeoleraceamarthasantiinflammatorypotentialthroughnlrp3inflammasomemodulation AT charleseliasassmann acaieuterpeoleraceamarthasantiinflammatorypotentialthroughnlrp3inflammasomemodulation AT anacristinaandreazza acaieuterpeoleraceamarthasantiinflammatorypotentialthroughnlrp3inflammasomemodulation AT martamariamedeirosfrescuraduarte acaieuterpeoleraceamarthasantiinflammatorypotentialthroughnlrp3inflammasomemodulation AT catiadossantosbranco acaieuterpeoleraceamarthasantiinflammatorypotentialthroughnlrp3inflammasomemodulation AT xinyangzhou acaieuterpeoleraceamarthasantiinflammatorypotentialthroughnlrp3inflammasomemodulation AT diulievalentedesouza acaieuterpeoleraceamarthasantiinflammatorypotentialthroughnlrp3inflammasomemodulation AT eulerestevesribeiro acaieuterpeoleraceamarthasantiinflammatorypotentialthroughnlrp3inflammasomemodulation AT ivanabeatricemanicadacruz acaieuterpeoleraceamarthasantiinflammatorypotentialthroughnlrp3inflammasomemodulation |