Metabolic Deregulations in Patients with Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) contributes to endocrine and metabolic complications for women worldwide. The aim of this study was to establish the usefulness of new anthropometric indices and atherogenic indices in the evaluation of metabolic disorders, in particular, glucose and insulin abnormal...
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MDPI AG
2023-02-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/2/302 |
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| author | Marzena Jabczyk Justyna Nowak Paweł Jagielski Bartosz Hudzik Karolina Kulik-Kupka Aleksander Włodarczyk Katarzyna Lar Barbara Zubelewicz-Szkodzińska |
| author_facet | Marzena Jabczyk Justyna Nowak Paweł Jagielski Bartosz Hudzik Karolina Kulik-Kupka Aleksander Włodarczyk Katarzyna Lar Barbara Zubelewicz-Szkodzińska |
| author_sort | Marzena Jabczyk |
| collection | DOAJ |
| description | Polycystic ovary syndrome (PCOS) contributes to endocrine and metabolic complications for women worldwide. The aim of this study was to establish the usefulness of new anthropometric indices and atherogenic indices in the evaluation of metabolic disorders, in particular, glucose and insulin abnormalities in the profiles of women with polycystic ovary syndrome (PCOS). In the study, a total of 49 women with PCOS aged between 18 and 39 years were recruited. All patients were tested for fasting glucose and insulin, lipid parameters, oral-glucose administration, and biochemical parameters. All of them underwent anthropometric measurements, such as BMI (body mass index), WHR (waist-to-hip ratio), WHtR (waist-to-height ratio), BAI (body adiposity index), VAI (visceral adiposity index), LAP (lipid accumulation product), BRI (body roundness index), ABSI (A body shape index), AIP (atherogenic risk of plasma), AC (atherogenic coefficient), Castelli risk index-I, Castelli risk index-II and (LCI) lipoprotein combine index, TG/HDL-C ratio, METS-IR (The metabolic score of insulin resistance), triglyceride glucose index (TyG index), triglyceride glucose-body mass index (TyG-BMI index) and triglyceride glucose-waist circumference index (TyG-WC index) were calculated. The analyzed anthropometric measurements/indices and atherogenic indices demonstrated significant correlations in PCOS women. T A strong relationship was found between fasting glucose, fasting insulin, glucose after 60 min, HOMA-IR index in the patients with PCOS. There was no significant relationship between HbA1c and other analyzed parameters and indices. Most of the analyzed anthropometric and atherogenic indices may be useful tools in evaluating metabolic disorders, and, in particular, glucose and insulin abnormalities in PCOS women. |
| first_indexed | 2024-03-11T08:26:32Z |
| format | Article |
| id | doaj.art-ac6b09bfbbda423e94243f903c4e2310 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T08:26:32Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-ac6b09bfbbda423e94243f903c4e23102023-11-16T22:05:41ZengMDPI AGMetabolites2218-19892023-02-0113230210.3390/metabo13020302Metabolic Deregulations in Patients with Polycystic Ovary SyndromeMarzena Jabczyk0Justyna Nowak1Paweł Jagielski2Bartosz Hudzik3Karolina Kulik-Kupka4Aleksander Włodarczyk5Katarzyna Lar6Barbara Zubelewicz-Szkodzińska7Department of Metabolic Disease Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia, 41-900 Bytom, PolandDepartment of Metabolic Disease Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia, 41-900 Bytom, PolandDepartment of Nutrition and Drug Research, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, 31-066 Cracow, PolandDepartment of Metabolic Disease Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia, 41-900 Bytom, PolandDepartment of Metabolic Disease Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia, 41-900 Bytom, PolandDistrict Hospital, 41-940 Piekary Slaskie, PolandDepartment of Metabolic Disease Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia, 41-900 Bytom, PolandDepartment of Metabolic Disease Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia, 41-900 Bytom, PolandPolycystic ovary syndrome (PCOS) contributes to endocrine and metabolic complications for women worldwide. The aim of this study was to establish the usefulness of new anthropometric indices and atherogenic indices in the evaluation of metabolic disorders, in particular, glucose and insulin abnormalities in the profiles of women with polycystic ovary syndrome (PCOS). In the study, a total of 49 women with PCOS aged between 18 and 39 years were recruited. All patients were tested for fasting glucose and insulin, lipid parameters, oral-glucose administration, and biochemical parameters. All of them underwent anthropometric measurements, such as BMI (body mass index), WHR (waist-to-hip ratio), WHtR (waist-to-height ratio), BAI (body adiposity index), VAI (visceral adiposity index), LAP (lipid accumulation product), BRI (body roundness index), ABSI (A body shape index), AIP (atherogenic risk of plasma), AC (atherogenic coefficient), Castelli risk index-I, Castelli risk index-II and (LCI) lipoprotein combine index, TG/HDL-C ratio, METS-IR (The metabolic score of insulin resistance), triglyceride glucose index (TyG index), triglyceride glucose-body mass index (TyG-BMI index) and triglyceride glucose-waist circumference index (TyG-WC index) were calculated. The analyzed anthropometric measurements/indices and atherogenic indices demonstrated significant correlations in PCOS women. T A strong relationship was found between fasting glucose, fasting insulin, glucose after 60 min, HOMA-IR index in the patients with PCOS. There was no significant relationship between HbA1c and other analyzed parameters and indices. Most of the analyzed anthropometric and atherogenic indices may be useful tools in evaluating metabolic disorders, and, in particular, glucose and insulin abnormalities in PCOS women.https://www.mdpi.com/2218-1989/13/2/302polycystic ovary syndromeatherogenic indicesanthropometric indicesmetabolic disorder |
| spellingShingle | Marzena Jabczyk Justyna Nowak Paweł Jagielski Bartosz Hudzik Karolina Kulik-Kupka Aleksander Włodarczyk Katarzyna Lar Barbara Zubelewicz-Szkodzińska Metabolic Deregulations in Patients with Polycystic Ovary Syndrome Metabolites polycystic ovary syndrome atherogenic indices anthropometric indices metabolic disorder |
| title | Metabolic Deregulations in Patients with Polycystic Ovary Syndrome |
| title_full | Metabolic Deregulations in Patients with Polycystic Ovary Syndrome |
| title_fullStr | Metabolic Deregulations in Patients with Polycystic Ovary Syndrome |
| title_full_unstemmed | Metabolic Deregulations in Patients with Polycystic Ovary Syndrome |
| title_short | Metabolic Deregulations in Patients with Polycystic Ovary Syndrome |
| title_sort | metabolic deregulations in patients with polycystic ovary syndrome |
| topic | polycystic ovary syndrome atherogenic indices anthropometric indices metabolic disorder |
| url | https://www.mdpi.com/2218-1989/13/2/302 |
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