Survival analysis of stage II gastric cancer patients after D2 gastrectomy: a Chinese people-based research
Abstract Objective The benefit of adjuvant chemotherapy is still controversial for stage II gastric cancer patients. This study aims to identify prognostic factors to guide individualized treatment for stage II gastric cancer patients. Methods We retrospectively reviewed 1121 stage II gastric cancer...
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-021-01937-9 |
| _version_ | 1818730623775277056 |
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| author | Zi-Jian Deng Run-Cong Nie Jun Lu Xi-Jie Chen Jun Xiang Chang-Ming Huang Ying-Bo Chen Jun-Sheng Peng Shi Chen |
| author_facet | Zi-Jian Deng Run-Cong Nie Jun Lu Xi-Jie Chen Jun Xiang Chang-Ming Huang Ying-Bo Chen Jun-Sheng Peng Shi Chen |
| author_sort | Zi-Jian Deng |
| collection | DOAJ |
| description | Abstract Objective The benefit of adjuvant chemotherapy is still controversial for stage II gastric cancer patients. This study aims to identify prognostic factors to guide individualized treatment for stage II gastric cancer patients. Methods We retrospectively reviewed 1121 stage II gastric cancer patients who underwent D2 radical gastrectomy from 2007 to 2017 in the Sixth Affiliated Hospital of Sun Yat-sen University, FuJian Medical School Affiliated Union Hospital and Sun Yat-sen University Cancer Center. Propensity score matching was used to ensure that the baseline data were balanced between the adjuvant chemotherapy group and surgery-only group. Kaplan–Meier survival and multivariate Cox regression analyses were carried out to identify independent prognostic factors. Results In univariate analysis, after propensity score matching, age, tumor location, tumor size, CEA, T stage and N stage were associated with overall survival (OS). Multivariate analysis illustrated that age ≥ 60 years old, linitis plastica and T4 were independent risk factors for OS, but lower location and adjuvant chemotherapy were protective factors. Conclusion Stage II gastric cancer patients with adverse prognostic factors (age ≥ 60, linitis plastica and T4) have poor prognosis. Adjuvant chemotherapy may be more beneficial for these patients. |
| first_indexed | 2024-12-17T23:04:44Z |
| format | Article |
| id | doaj.art-ac6b752abd65436588110d597ade8fab |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-17T23:04:44Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-ac6b752abd65436588110d597ade8fab2022-12-21T21:29:19ZengBMCBMC Gastroenterology1471-230X2021-10-012111910.1186/s12876-021-01937-9Survival analysis of stage II gastric cancer patients after D2 gastrectomy: a Chinese people-based researchZi-Jian Deng0Run-Cong Nie1Jun Lu2Xi-Jie Chen3Jun Xiang4Chang-Ming Huang5Ying-Bo Chen6Jun-Sheng Peng7Shi Chen8Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Gastric Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineDepartment of Gastric Surgery, Fujian Medical University Union HospitalGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-Sen UniversityGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Gastric Surgery, Fujian Medical University Union HospitalDepartment of Gastric Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-Sen UniversityGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-Sen UniversityAbstract Objective The benefit of adjuvant chemotherapy is still controversial for stage II gastric cancer patients. This study aims to identify prognostic factors to guide individualized treatment for stage II gastric cancer patients. Methods We retrospectively reviewed 1121 stage II gastric cancer patients who underwent D2 radical gastrectomy from 2007 to 2017 in the Sixth Affiliated Hospital of Sun Yat-sen University, FuJian Medical School Affiliated Union Hospital and Sun Yat-sen University Cancer Center. Propensity score matching was used to ensure that the baseline data were balanced between the adjuvant chemotherapy group and surgery-only group. Kaplan–Meier survival and multivariate Cox regression analyses were carried out to identify independent prognostic factors. Results In univariate analysis, after propensity score matching, age, tumor location, tumor size, CEA, T stage and N stage were associated with overall survival (OS). Multivariate analysis illustrated that age ≥ 60 years old, linitis plastica and T4 were independent risk factors for OS, but lower location and adjuvant chemotherapy were protective factors. Conclusion Stage II gastric cancer patients with adverse prognostic factors (age ≥ 60, linitis plastica and T4) have poor prognosis. Adjuvant chemotherapy may be more beneficial for these patients.https://doi.org/10.1186/s12876-021-01937-9Gastric cancerStage IIPrognosisAdjuvant chemotherapyPropensity score matching |
| spellingShingle | Zi-Jian Deng Run-Cong Nie Jun Lu Xi-Jie Chen Jun Xiang Chang-Ming Huang Ying-Bo Chen Jun-Sheng Peng Shi Chen Survival analysis of stage II gastric cancer patients after D2 gastrectomy: a Chinese people-based research BMC Gastroenterology Gastric cancer Stage II Prognosis Adjuvant chemotherapy Propensity score matching |
| title | Survival analysis of stage II gastric cancer patients after D2 gastrectomy: a Chinese people-based research |
| title_full | Survival analysis of stage II gastric cancer patients after D2 gastrectomy: a Chinese people-based research |
| title_fullStr | Survival analysis of stage II gastric cancer patients after D2 gastrectomy: a Chinese people-based research |
| title_full_unstemmed | Survival analysis of stage II gastric cancer patients after D2 gastrectomy: a Chinese people-based research |
| title_short | Survival analysis of stage II gastric cancer patients after D2 gastrectomy: a Chinese people-based research |
| title_sort | survival analysis of stage ii gastric cancer patients after d2 gastrectomy a chinese people based research |
| topic | Gastric cancer Stage II Prognosis Adjuvant chemotherapy Propensity score matching |
| url | https://doi.org/10.1186/s12876-021-01937-9 |
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