Gut microbiota are differentially correlated with blood pressure status in African American collegiate athletes: A pilot study
Abstract Hypertension (HTN) is common among athletes and the most recent epidemiologic data reports that cardiovascular (CV) sudden death is significantly greater in African Americans (AAs). Gut microbial dysbiosis (a poorly diverse stool microbial profile) has been associated with HTN in sedentary...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.15982 |
| _version_ | 1827270712414437376 |
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| author | Taylor Hogue Jarrad Hampton‐Marcell Ian M. Carroll Troy Purdom Heather Colleran TJ Exford Michael Brown Marc D. Cook |
| author_facet | Taylor Hogue Jarrad Hampton‐Marcell Ian M. Carroll Troy Purdom Heather Colleran TJ Exford Michael Brown Marc D. Cook |
| author_sort | Taylor Hogue |
| collection | DOAJ |
| description | Abstract Hypertension (HTN) is common among athletes and the most recent epidemiologic data reports that cardiovascular (CV) sudden death is significantly greater in African Americans (AAs). Gut microbial dysbiosis (a poorly diverse stool microbial profile) has been associated with HTN in sedentary people but microbial characteristics of athletes with HTN are unknown. Our purpose was to differentiate microbiome characteristics associated with BP status in AA collegiate athletes. Thirty AA collegiate athletes were stratified by normal BP (systolic BP (SBP) ≤130 mmHg; n = 15) and HTN (SBP ≥130 mmHg; n = 15). 16S rRNA gene sequencing was performed on stool samples to identify microbes at the genus level. We did not observe any significant differences in alpha diversity, but beta diversity was different between groups. Principal coordinate analysis was significantly different (PERMANOVA, p < 0.05, R = 0.235) between groups. Spearman rank correlations showed a significant (p < 0.05) correlation between systolic BP and abundances for Adlercreutzia (R = 0.64), Coprococcus (R = 0.49), Granulicatella (R = 0.63), and Veillonella (R = 0.41). Gut microbial characteristics were associated with differentially abundant microbial genus' and BP status. These results will direct future studies to define the functions of these microbes associated with BP in athletes. |
| first_indexed | 2024-04-24T17:09:42Z |
| format | Article |
| id | doaj.art-ac6d311bf3f94c06b5fa827079fbd32f |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2025-03-22T05:25:47Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-ac6d311bf3f94c06b5fa827079fbd32f2024-04-27T00:35:34ZengWileyPhysiological Reports2051-817X2024-03-01126n/an/a10.14814/phy2.15982Gut microbiota are differentially correlated with blood pressure status in African American collegiate athletes: A pilot studyTaylor Hogue0Jarrad Hampton‐Marcell1Ian M. Carroll2Troy Purdom3Heather Colleran4TJ Exford5Michael Brown6Marc D. Cook7Department of Kinesiology North Carolina Agriculture and Technical State University Greensboro North Carolina USADepartment of Biological Sciences University of Illinois at Chicago Chicago Illinois USADepartment of Nutrition University of North Carolina at Chapel Hill Chapel Hill North Carolina USADepartment of Kinesiology North Carolina Agriculture and Technical State University Greensboro North Carolina USADepartment of Nutrition North Carolina Agriculture and Technical State University Greensboro North Carolina USAEducation & Research Department Dayton VA Medical Center Dayton Ohio USADepartment of Kinesiology University of Maryland College Park Maryland USADepartment of Kinesiology North Carolina Agriculture and Technical State University Greensboro North Carolina USAAbstract Hypertension (HTN) is common among athletes and the most recent epidemiologic data reports that cardiovascular (CV) sudden death is significantly greater in African Americans (AAs). Gut microbial dysbiosis (a poorly diverse stool microbial profile) has been associated with HTN in sedentary people but microbial characteristics of athletes with HTN are unknown. Our purpose was to differentiate microbiome characteristics associated with BP status in AA collegiate athletes. Thirty AA collegiate athletes were stratified by normal BP (systolic BP (SBP) ≤130 mmHg; n = 15) and HTN (SBP ≥130 mmHg; n = 15). 16S rRNA gene sequencing was performed on stool samples to identify microbes at the genus level. We did not observe any significant differences in alpha diversity, but beta diversity was different between groups. Principal coordinate analysis was significantly different (PERMANOVA, p < 0.05, R = 0.235) between groups. Spearman rank correlations showed a significant (p < 0.05) correlation between systolic BP and abundances for Adlercreutzia (R = 0.64), Coprococcus (R = 0.49), Granulicatella (R = 0.63), and Veillonella (R = 0.41). Gut microbial characteristics were associated with differentially abundant microbial genus' and BP status. These results will direct future studies to define the functions of these microbes associated with BP in athletes.https://doi.org/10.14814/phy2.15982African Americanathletegut microbiomehypertension |
| spellingShingle | Taylor Hogue Jarrad Hampton‐Marcell Ian M. Carroll Troy Purdom Heather Colleran TJ Exford Michael Brown Marc D. Cook Gut microbiota are differentially correlated with blood pressure status in African American collegiate athletes: A pilot study Physiological Reports African American athlete gut microbiome hypertension |
| title | Gut microbiota are differentially correlated with blood pressure status in African American collegiate athletes: A pilot study |
| title_full | Gut microbiota are differentially correlated with blood pressure status in African American collegiate athletes: A pilot study |
| title_fullStr | Gut microbiota are differentially correlated with blood pressure status in African American collegiate athletes: A pilot study |
| title_full_unstemmed | Gut microbiota are differentially correlated with blood pressure status in African American collegiate athletes: A pilot study |
| title_short | Gut microbiota are differentially correlated with blood pressure status in African American collegiate athletes: A pilot study |
| title_sort | gut microbiota are differentially correlated with blood pressure status in african american collegiate athletes a pilot study |
| topic | African American athlete gut microbiome hypertension |
| url | https://doi.org/10.14814/phy2.15982 |
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