Pineal parenchymal tumors: Case series
Background: Pineal parenchymal tumors (PPTs) are uncommon tumors comprising of pineocytoma (PC), pineal parenchymal tumor of intermediate differentiation (PPTID) and pineoblastoma (PB). Morphological sub typing and histological grading based on mitotic index and neurofilament (NF) immunostaining are...
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| Format: | Article |
| Language: | English |
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KIMS Foundation and Research Center
2016-01-01
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| Series: | Journal of Medical and Scientific Research |
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| Online Access: | http://jmsronline.com/article.aspx?ID=Pineal-parenchymal-tumors-Case-series |
| _version_ | 1818529500648964096 |
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| author | Mohiuddin KM Sailaja M Rao SI Panigrahi MK Reddy KA Naidu CS |
| author_facet | Mohiuddin KM Sailaja M Rao SI Panigrahi MK Reddy KA Naidu CS |
| author_sort | Mohiuddin KM |
| collection | DOAJ |
| description | Background: Pineal parenchymal tumors (PPTs) are uncommon tumors comprising of pineocytoma (PC), pineal parenchymal tumor of intermediate differentiation (PPTID) and pineoblastoma (PB). Morphological sub typing and histological grading based on mitotic index and neurofilament (NF) immunostaining are the factors affecting the survival of these patients. Treatment strategy and prognosis of PPTIDs remain controversial with limited data available on pathologic features and biologic behavior of PPTID.
Case series: We report a series of 8 pineal parenchymal tumors over a period of 5 years with special reference to PPTIDs. The series includes 3 cases of PC, 2 of PPTID and 3 of PB. Patients underwent decompression, microsurgical/ stereotactic/ endoscopic biopsy. Histological features with MIB1 LI (labelling index) and NF immunostaining were studied and showed varied presentation. One case each of PC and PPTID showed ganglion like cells. Both PPTIDs showed 8% and 20% MIB1 LI. All PBs showed brisk mitosis hemorrhage and necrosis except for one case where mitosis was not clearly evident but showed high MIB1 LI (50%).
Conclusion: PCs with ganglionic differentiation have an essentially benign course.
Ganglionic differentiation in PPTIDs, its impact on the prognosis and as a differentiating factor between PPTID grade II and grade III needs further study. |
| first_indexed | 2024-12-11T17:07:40Z |
| format | Article |
| id | doaj.art-ac6dbf5f2807490ea4c3a6ad7fe4c3c1 |
| institution | Directory Open Access Journal |
| issn | 2321-1326 2394-112X |
| language | English |
| last_indexed | 2024-12-11T17:07:40Z |
| publishDate | 2016-01-01 |
| publisher | KIMS Foundation and Research Center |
| record_format | Article |
| series | Journal of Medical and Scientific Research |
| spelling | doaj.art-ac6dbf5f2807490ea4c3a6ad7fe4c3c12022-12-22T00:57:38ZengKIMS Foundation and Research CenterJournal of Medical and Scientific Research2321-13262394-112X2016-01-0141111410.17727/JMSR.2016/4-004Pineal parenchymal tumors: Case seriesMohiuddin KM0Sailaja M1Rao SI2Panigrahi MK3Reddy KA4Naidu CS5Department of Pathology, Krishna Institute of Medical Sciences, Secunderabad, Telangana, IndiaDepartment of Pathology, Krishna Institute of Medical Sciences, Secunderabad, Telangana, IndiaDepartment of Pathology, Krishna Institute of Medical Sciences, Secunderabad, Telangana, IndiaDepartment of Neurosurgery, Krishna Institute of Medical Sciences, Secunderabad, Telangana, IndiaDepartment of Neurosurgery, Krishna Institute of Medical Sciences, Secunderabad, Telangana, IndiaDepartment of Neurosurgery, Krishna Institute of Medical Sciences, Secunderabad, Telangana, IndiaBackground: Pineal parenchymal tumors (PPTs) are uncommon tumors comprising of pineocytoma (PC), pineal parenchymal tumor of intermediate differentiation (PPTID) and pineoblastoma (PB). Morphological sub typing and histological grading based on mitotic index and neurofilament (NF) immunostaining are the factors affecting the survival of these patients. Treatment strategy and prognosis of PPTIDs remain controversial with limited data available on pathologic features and biologic behavior of PPTID. Case series: We report a series of 8 pineal parenchymal tumors over a period of 5 years with special reference to PPTIDs. The series includes 3 cases of PC, 2 of PPTID and 3 of PB. Patients underwent decompression, microsurgical/ stereotactic/ endoscopic biopsy. Histological features with MIB1 LI (labelling index) and NF immunostaining were studied and showed varied presentation. One case each of PC and PPTID showed ganglion like cells. Both PPTIDs showed 8% and 20% MIB1 LI. All PBs showed brisk mitosis hemorrhage and necrosis except for one case where mitosis was not clearly evident but showed high MIB1 LI (50%). Conclusion: PCs with ganglionic differentiation have an essentially benign course. Ganglionic differentiation in PPTIDs, its impact on the prognosis and as a differentiating factor between PPTID grade II and grade III needs further study.http://jmsronline.com/article.aspx?ID=Pineal-parenchymal-tumors-Case-seriesPineocytomapineal parenchymapineoblastomaMIB1 LIneurofilamentsynaptophysin |
| spellingShingle | Mohiuddin KM Sailaja M Rao SI Panigrahi MK Reddy KA Naidu CS Pineal parenchymal tumors: Case series Journal of Medical and Scientific Research Pineocytoma pineal parenchyma pineoblastoma MIB1 LI neurofilament synaptophysin |
| title | Pineal parenchymal tumors: Case series |
| title_full | Pineal parenchymal tumors: Case series |
| title_fullStr | Pineal parenchymal tumors: Case series |
| title_full_unstemmed | Pineal parenchymal tumors: Case series |
| title_short | Pineal parenchymal tumors: Case series |
| title_sort | pineal parenchymal tumors case series |
| topic | Pineocytoma pineal parenchyma pineoblastoma MIB1 LI neurofilament synaptophysin |
| url | http://jmsronline.com/article.aspx?ID=Pineal-parenchymal-tumors-Case-series |
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