Progress in the treatment of drug-induced liver injury with natural products
There are numerous prescription drugs and non-prescription drugs that cause drug-induced liver injury (DILI), which is the main cause of liver disease in humans around the globe. Its mechanism becomes clearer as the disease is studied further. For an instance, when acetaminophen (APAP) is taken in e...
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| Format: | Article |
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Elsevier
2022-09-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661822003061 |
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| author | Yuan-kai Sun Ya-fei Zhang Li Xie Fan Rong Xing-yu Zhu Jing Xie Huan Zhou Tao Xu |
| author_facet | Yuan-kai Sun Ya-fei Zhang Li Xie Fan Rong Xing-yu Zhu Jing Xie Huan Zhou Tao Xu |
| author_sort | Yuan-kai Sun |
| collection | DOAJ |
| description | There are numerous prescription drugs and non-prescription drugs that cause drug-induced liver injury (DILI), which is the main cause of liver disease in humans around the globe. Its mechanism becomes clearer as the disease is studied further. For an instance, when acetaminophen (APAP) is taken in excess, it produces N-acetyl-p-benzoquinone imine (NAPQI) that binds to biomacromolecules in the liver causing liver injury. Treatment of DILI with traditional Chinese medicine (TCM) has shown to be effective. For example, activation of the Nrf2 signaling pathway as well as regulation of glutathione (GSH) synthesis, coupling, and excretion are the mechanisms by which ginsenoside Rg1 (Rg1) treats APAP-induced acute liver injury. Nevertheless, reducing the toxicity of TCM in treating DILI is still a problem to be overcome at present and in the future. Accumulated evidences show that hydrogel-based nanocomposite may be an excellent carrier for TCM. Therefore, we reviewed TCM with potential anti-DILI, focusing on the signaling pathway of these drugs' anti-DILI effect, as well as the possibility and prospect of treating DILI by TCM based on hydrogel materials in the future. In conclusion, this review provides new insights to further explore TCM in the treatment of DILI. |
| first_indexed | 2024-03-08T17:07:10Z |
| format | Article |
| id | doaj.art-ac70ed6d708a4bd780b80e559e149ee5 |
| institution | Directory Open Access Journal |
| issn | 1096-1186 |
| language | English |
| last_indexed | 2024-03-08T17:07:10Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj.art-ac70ed6d708a4bd780b80e559e149ee52024-01-04T04:37:56ZengElsevierPharmacological Research1096-11862022-09-01183106361Progress in the treatment of drug-induced liver injury with natural productsYuan-kai Sun0Ya-fei Zhang1Li Xie2Fan Rong3Xing-yu Zhu4Jing Xie5Huan Zhou6Tao Xu7Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei 230032, China; Anhui Key Lab. of Bioactivity of Natural Products, Institute for Liver Diseases of Anhui Medical University, Anhui Medical University, Hefei 230032, ChinaDepartment of Infectious Diseases, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, ChinaDepartment of Ultrasound, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, ChinaPeople's Hospital of Lujiang County, Anhui province, Lujiang 231500, ChinaNational Institute of Drug Clinical Trial, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China; School of Pharmacy, Bengbu Medical College, Bengbu 233004, ChinaNational Institute of Drug Clinical Trial, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, ChinaNational Institute of Drug Clinical Trial, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China; School of Pharmacy, Bengbu Medical College, Bengbu 233004, China; Correspondence to: School of Pharmacy, Bengbu Medical College, 287 Changhuai road, Bengbu, Anhui Province 233004, China.Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei 230032, China; Anhui Key Lab. of Bioactivity of Natural Products, Institute for Liver Diseases of Anhui Medical University, Anhui Medical University, Hefei 230032, China; Correspondence to: School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei, Anhui Province 230032, China.There are numerous prescription drugs and non-prescription drugs that cause drug-induced liver injury (DILI), which is the main cause of liver disease in humans around the globe. Its mechanism becomes clearer as the disease is studied further. For an instance, when acetaminophen (APAP) is taken in excess, it produces N-acetyl-p-benzoquinone imine (NAPQI) that binds to biomacromolecules in the liver causing liver injury. Treatment of DILI with traditional Chinese medicine (TCM) has shown to be effective. For example, activation of the Nrf2 signaling pathway as well as regulation of glutathione (GSH) synthesis, coupling, and excretion are the mechanisms by which ginsenoside Rg1 (Rg1) treats APAP-induced acute liver injury. Nevertheless, reducing the toxicity of TCM in treating DILI is still a problem to be overcome at present and in the future. Accumulated evidences show that hydrogel-based nanocomposite may be an excellent carrier for TCM. Therefore, we reviewed TCM with potential anti-DILI, focusing on the signaling pathway of these drugs' anti-DILI effect, as well as the possibility and prospect of treating DILI by TCM based on hydrogel materials in the future. In conclusion, this review provides new insights to further explore TCM in the treatment of DILI.http://www.sciencedirect.com/science/article/pii/S1043661822003061DILITCMNatural productsHydrogel |
| spellingShingle | Yuan-kai Sun Ya-fei Zhang Li Xie Fan Rong Xing-yu Zhu Jing Xie Huan Zhou Tao Xu Progress in the treatment of drug-induced liver injury with natural products Pharmacological Research DILI TCM Natural products Hydrogel |
| title | Progress in the treatment of drug-induced liver injury with natural products |
| title_full | Progress in the treatment of drug-induced liver injury with natural products |
| title_fullStr | Progress in the treatment of drug-induced liver injury with natural products |
| title_full_unstemmed | Progress in the treatment of drug-induced liver injury with natural products |
| title_short | Progress in the treatment of drug-induced liver injury with natural products |
| title_sort | progress in the treatment of drug induced liver injury with natural products |
| topic | DILI TCM Natural products Hydrogel |
| url | http://www.sciencedirect.com/science/article/pii/S1043661822003061 |
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