Age-adjusted quick Sequential Organ Failure Assessment score for predicting mortality and disease severity in children with infection: a systematic review and meta-analysis
Abstract We assessed the diagnostic accuracy of the age-adjusted quick Sequential Organ Failure Assessment score (qSOFA) for predicting mortality and disease severity in pediatric patients with suspected or confirmed infection. We conducted a systematic search of PubMed, EMBASE, the Cochrane Library...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-01271-w |
| _version_ | 1818896777490726912 |
|---|---|
| author | Sohyun Eun Haemin Kim Ha Yan Kim Myeongjee Lee Go Eun Bae Heoungjin Kim Chung Mo Koo Moon Kyu Kim Seo Hee Yoon |
| author_facet | Sohyun Eun Haemin Kim Ha Yan Kim Myeongjee Lee Go Eun Bae Heoungjin Kim Chung Mo Koo Moon Kyu Kim Seo Hee Yoon |
| author_sort | Sohyun Eun |
| collection | DOAJ |
| description | Abstract We assessed the diagnostic accuracy of the age-adjusted quick Sequential Organ Failure Assessment score (qSOFA) for predicting mortality and disease severity in pediatric patients with suspected or confirmed infection. We conducted a systematic search of PubMed, EMBASE, the Cochrane Library, and Web of Science. Eleven studies with a total of 172,569 patients were included in the meta-analysis. The pooled sensitivity, specificity, and diagnostic odds ratio of the age-adjusted qSOFA for predicting mortality and disease severity were 0.69 (95% confidence interval [CI] 0.53–0.81), 0.71 (95% CI 0.36–0.91), and 6.57 (95% CI 4.46–9.67), respectively. The area under the summary receiver-operating characteristic curve was 0.733. The pooled sensitivity and specificity for predicting mortality were 0.73 (95% CI 0.66–0.79) and 0.63 (95% CI 0.21–0.92), respectively. The pooled sensitivity and specificity for predicting disease severity were 0.73 (95% CI 0.21–0.97) and 0.72 (95% CI 0.11–0.98), respectively. The performance of the age-adjusted qSOFA for predicting mortality and disease severity was better in emergency department patients than in intensive care unit patients. The age-adjusted qSOFA has moderate predictive power and can help in rapidly identifying at-risk children, but its utility may be limited by its insufficient sensitivity. |
| first_indexed | 2024-12-19T19:05:40Z |
| format | Article |
| id | doaj.art-ac71b4ba29d34c3da72b5cff494723fb |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T19:05:40Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ac71b4ba29d34c3da72b5cff494723fb2022-12-21T20:09:28ZengNature PortfolioScientific Reports2045-23222021-11-011111910.1038/s41598-021-01271-wAge-adjusted quick Sequential Organ Failure Assessment score for predicting mortality and disease severity in children with infection: a systematic review and meta-analysisSohyun Eun0Haemin Kim1Ha Yan Kim2Myeongjee Lee3Go Eun Bae4Heoungjin Kim5Chung Mo Koo6Moon Kyu Kim7Seo Hee Yoon8Department of Pediatrics, Severance Children’s Hospital, Yonsei University College of MedicineDepartment of Pediatrics, Severance Children’s Hospital, Yonsei University College of MedicineBiostatistics Collaboration Unit, Department of Biomedical Systems Informatics, Yonsei University College of MedicineBiostatistics Collaboration Unit, Department of Biomedical Systems Informatics, Yonsei University College of MedicineDepartment of Emergency Medicine, Yonsei University College of MedicineDepartment of Pediatrics, Severance Children’s Hospital, Yonsei University College of MedicineDepartment of Pediatrics, Severance Children’s Hospital, Yonsei University College of MedicineDepartment of Pediatrics, Severance Children’s Hospital, Yonsei University College of MedicineDepartment of Pediatrics, Severance Children’s Hospital, Yonsei University College of MedicineAbstract We assessed the diagnostic accuracy of the age-adjusted quick Sequential Organ Failure Assessment score (qSOFA) for predicting mortality and disease severity in pediatric patients with suspected or confirmed infection. We conducted a systematic search of PubMed, EMBASE, the Cochrane Library, and Web of Science. Eleven studies with a total of 172,569 patients were included in the meta-analysis. The pooled sensitivity, specificity, and diagnostic odds ratio of the age-adjusted qSOFA for predicting mortality and disease severity were 0.69 (95% confidence interval [CI] 0.53–0.81), 0.71 (95% CI 0.36–0.91), and 6.57 (95% CI 4.46–9.67), respectively. The area under the summary receiver-operating characteristic curve was 0.733. The pooled sensitivity and specificity for predicting mortality were 0.73 (95% CI 0.66–0.79) and 0.63 (95% CI 0.21–0.92), respectively. The pooled sensitivity and specificity for predicting disease severity were 0.73 (95% CI 0.21–0.97) and 0.72 (95% CI 0.11–0.98), respectively. The performance of the age-adjusted qSOFA for predicting mortality and disease severity was better in emergency department patients than in intensive care unit patients. The age-adjusted qSOFA has moderate predictive power and can help in rapidly identifying at-risk children, but its utility may be limited by its insufficient sensitivity.https://doi.org/10.1038/s41598-021-01271-w |
| spellingShingle | Sohyun Eun Haemin Kim Ha Yan Kim Myeongjee Lee Go Eun Bae Heoungjin Kim Chung Mo Koo Moon Kyu Kim Seo Hee Yoon Age-adjusted quick Sequential Organ Failure Assessment score for predicting mortality and disease severity in children with infection: a systematic review and meta-analysis Scientific Reports |
| title | Age-adjusted quick Sequential Organ Failure Assessment score for predicting mortality and disease severity in children with infection: a systematic review and meta-analysis |
| title_full | Age-adjusted quick Sequential Organ Failure Assessment score for predicting mortality and disease severity in children with infection: a systematic review and meta-analysis |
| title_fullStr | Age-adjusted quick Sequential Organ Failure Assessment score for predicting mortality and disease severity in children with infection: a systematic review and meta-analysis |
| title_full_unstemmed | Age-adjusted quick Sequential Organ Failure Assessment score for predicting mortality and disease severity in children with infection: a systematic review and meta-analysis |
| title_short | Age-adjusted quick Sequential Organ Failure Assessment score for predicting mortality and disease severity in children with infection: a systematic review and meta-analysis |
| title_sort | age adjusted quick sequential organ failure assessment score for predicting mortality and disease severity in children with infection a systematic review and meta analysis |
| url | https://doi.org/10.1038/s41598-021-01271-w |
| work_keys_str_mv | AT sohyuneun ageadjustedquicksequentialorganfailureassessmentscoreforpredictingmortalityanddiseaseseverityinchildrenwithinfectionasystematicreviewandmetaanalysis AT haeminkim ageadjustedquicksequentialorganfailureassessmentscoreforpredictingmortalityanddiseaseseverityinchildrenwithinfectionasystematicreviewandmetaanalysis AT hayankim ageadjustedquicksequentialorganfailureassessmentscoreforpredictingmortalityanddiseaseseverityinchildrenwithinfectionasystematicreviewandmetaanalysis AT myeongjeelee ageadjustedquicksequentialorganfailureassessmentscoreforpredictingmortalityanddiseaseseverityinchildrenwithinfectionasystematicreviewandmetaanalysis AT goeunbae ageadjustedquicksequentialorganfailureassessmentscoreforpredictingmortalityanddiseaseseverityinchildrenwithinfectionasystematicreviewandmetaanalysis AT heoungjinkim ageadjustedquicksequentialorganfailureassessmentscoreforpredictingmortalityanddiseaseseverityinchildrenwithinfectionasystematicreviewandmetaanalysis AT chungmokoo ageadjustedquicksequentialorganfailureassessmentscoreforpredictingmortalityanddiseaseseverityinchildrenwithinfectionasystematicreviewandmetaanalysis AT moonkyukim ageadjustedquicksequentialorganfailureassessmentscoreforpredictingmortalityanddiseaseseverityinchildrenwithinfectionasystematicreviewandmetaanalysis AT seoheeyoon ageadjustedquicksequentialorganfailureassessmentscoreforpredictingmortalityanddiseaseseverityinchildrenwithinfectionasystematicreviewandmetaanalysis |