KRAS mutation analysis of single circulating tumor cells from patients with metastatic colorectal cancer

KRAS mutation analysis of single circulating tumor cells from patients with metastatic colorectal cancer

Abstract Background The molecular profiles of tumors may inform the selection of appropriate targeted therapies. Circulating tumor cells (CTCs) reflect the real-time status of tumor genotypes. CTCs exhibit high genetic heterogeneity within a patient; accordingly, the analysis of individual CTCs, inc...

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Bibliographic Details
Main Authors: Yuurin Kondo, Kazuhiko Hayashi, Kazuyuki Kawakami, Yukari Miwa, Hiroshi Hayashi, Masakazu Yamamoto
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Cancer
Subjects:
Circulating tumor cells
Mutation analysis
KRAS
Single cell analysis
Heterogeneity
Online Access:http://link.springer.com/article/10.1186/s12885-017-3305-6

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