Phytic Acid: Properties and Potential Applications in Dentistry
Inositol hexaphosphate (IP6) is the most abundant inositol phosphate in nature and an essential molecule for different biological functions. IP6 has a unique structure granting it distinctive properties; a high negative charge density provides IP6 with an immense chelating ability and valuable antio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Materials |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmats.2021.638909/full |
| _version_ | 1819140671774130176 |
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| author | Mohannad Nassar Rania Nassar Rania Nassar Husain Maki Abdullah Al-Yagoob Mahmood Hachim Abiola Senok David Williams Noriko Hiraishi |
| author_facet | Mohannad Nassar Rania Nassar Rania Nassar Husain Maki Abdullah Al-Yagoob Mahmood Hachim Abiola Senok David Williams Noriko Hiraishi |
| author_sort | Mohannad Nassar |
| collection | DOAJ |
| description | Inositol hexaphosphate (IP6) is the most abundant inositol phosphate in nature and an essential molecule for different biological functions. IP6 has a unique structure granting it distinctive properties; a high negative charge density provides IP6 with an immense chelating ability and valuable antioxidant properties. IP6 is also simple and cost-effective to produce. These features have attracted researchers and entrepreneurs to further study IP6 for a wide variety of applications in areas such as pharmaceutical, food and chemical industries, medicine, pharmacy, nutrition, and dentistry. The interest in IP6 in the dental field unfolded many decades ago following identification of a cariostatic ability and a positive impact on reducing enamel dissolution. Subsequently, IP6’s anti-plaque, anti-calculus and cement-forming properties have been investigated. Despite encouraging findings, there was a phase of decreased attention to IP6 which slowed down research progress. However, the potential use of IP6 has recently been revisited through several publications that provided deeper understanding into its mechanisms of action in the aforementioned applications. Studies have also explored new applications in endodontics, adhesive, preventive and regenerative dentistry, and IP6’s role in improving the characteristics and performance of dental materials. Evidence of the merits of IP6 in dentistry is now substantial, and this narrative review presents and discusses the different applications proposed in the literature and gives insights of future use of IP6 in the fields of orthodontics, implant and pediatric dentistry. |
| first_indexed | 2024-12-22T11:42:16Z |
| format | Article |
| id | doaj.art-ac734ccf5d0446d68b2bee1e8cf04a73 |
| institution | Directory Open Access Journal |
| issn | 2296-8016 |
| language | English |
| last_indexed | 2024-12-22T11:42:16Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Materials |
| spelling | doaj.art-ac734ccf5d0446d68b2bee1e8cf04a732022-12-21T18:27:15ZengFrontiers Media S.A.Frontiers in Materials2296-80162021-03-01810.3389/fmats.2021.638909638909Phytic Acid: Properties and Potential Applications in DentistryMohannad Nassar0Rania Nassar1Rania Nassar2Husain Maki3Abdullah Al-Yagoob4Mahmood Hachim5Abiola Senok6David Williams7Noriko Hiraishi8Department of Preventive and Restorative Dentistry, College of Dental Medicine, University of Sharjah, Sharjah, United Arab EmiratesCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab EmiratesOral and Biomedical Sciences, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, United KingdomSpeciality Dental Residency Program, Ministry of Health, Juffair, BahrainRas Al Khaimah College of Dental Sciences, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah, United Arab EmiratesCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab EmiratesCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab EmiratesOral and Biomedical Sciences, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, United KingdomDepartment of Cariology and Operative Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, JapanInositol hexaphosphate (IP6) is the most abundant inositol phosphate in nature and an essential molecule for different biological functions. IP6 has a unique structure granting it distinctive properties; a high negative charge density provides IP6 with an immense chelating ability and valuable antioxidant properties. IP6 is also simple and cost-effective to produce. These features have attracted researchers and entrepreneurs to further study IP6 for a wide variety of applications in areas such as pharmaceutical, food and chemical industries, medicine, pharmacy, nutrition, and dentistry. The interest in IP6 in the dental field unfolded many decades ago following identification of a cariostatic ability and a positive impact on reducing enamel dissolution. Subsequently, IP6’s anti-plaque, anti-calculus and cement-forming properties have been investigated. Despite encouraging findings, there was a phase of decreased attention to IP6 which slowed down research progress. However, the potential use of IP6 has recently been revisited through several publications that provided deeper understanding into its mechanisms of action in the aforementioned applications. Studies have also explored new applications in endodontics, adhesive, preventive and regenerative dentistry, and IP6’s role in improving the characteristics and performance of dental materials. Evidence of the merits of IP6 in dentistry is now substantial, and this narrative review presents and discusses the different applications proposed in the literature and gives insights of future use of IP6 in the fields of orthodontics, implant and pediatric dentistry.https://www.frontiersin.org/articles/10.3389/fmats.2021.638909/fulladhesiveapplicationcariostaticcementdentistryinositol hexakisphosphate |
| spellingShingle | Mohannad Nassar Rania Nassar Rania Nassar Husain Maki Abdullah Al-Yagoob Mahmood Hachim Abiola Senok David Williams Noriko Hiraishi Phytic Acid: Properties and Potential Applications in Dentistry Frontiers in Materials adhesive application cariostatic cement dentistry inositol hexakisphosphate |
| title | Phytic Acid: Properties and Potential Applications in Dentistry |
| title_full | Phytic Acid: Properties and Potential Applications in Dentistry |
| title_fullStr | Phytic Acid: Properties and Potential Applications in Dentistry |
| title_full_unstemmed | Phytic Acid: Properties and Potential Applications in Dentistry |
| title_short | Phytic Acid: Properties and Potential Applications in Dentistry |
| title_sort | phytic acid properties and potential applications in dentistry |
| topic | adhesive application cariostatic cement dentistry inositol hexakisphosphate |
| url | https://www.frontiersin.org/articles/10.3389/fmats.2021.638909/full |
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