Association of angiotensin II and receptors in peri-implantation endometrium with microvessel density and pregnancy outcomes of women with recurrent implantation failure after embryo transfer
PurposeInvestigate whether local angiotensin II (AngII) and its AngII type 1 and 2 receptors (AT1R, AT2R) in the endometrium are different and correlate with microvessel density in women with reproductive failure and pregnancy outcomes.MethodsEndometrium during the window of implantation from 40 wom...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1206326/full |
| _version_ | 1797732668911124480 |
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| author | Ruofan Qi Tao Zhang Yingying Zhang Jacqueline Pui Wah Chung Wen-Jui Yang Wen-Jui Yang Chi Chiu Wang Chi Chiu Wang Chi Chiu Wang Chi Chiu Wang |
| author_facet | Ruofan Qi Tao Zhang Yingying Zhang Jacqueline Pui Wah Chung Wen-Jui Yang Wen-Jui Yang Chi Chiu Wang Chi Chiu Wang Chi Chiu Wang Chi Chiu Wang |
| author_sort | Ruofan Qi |
| collection | DOAJ |
| description | PurposeInvestigate whether local angiotensin II (AngII) and its AngII type 1 and 2 receptors (AT1R, AT2R) in the endometrium are different and correlate with microvessel density in women with reproductive failure and pregnancy outcomes.MethodsEndometrium during the window of implantation from 40 women with recurrent miscarriage (RM) and 40 with recurrent implantation failure (RIF) were compared with 27 fertile women. Peri-implantation endometrium from 54 women prior to euploid embryo transfer were collected and compared in women with successful pregnancy and unsuccessful pregnancy.ResultsCompared with fertile women, expression of AT2R was significantly lower, while AT1R/AT2R expression ratio was significantly higher in the stroma of the RIF group. Endometrium arteriole MVD was significantly lower and negatively correlated with the AT1R/AT2R expression ratio in the stroma of the RIF group. No significant differences and correlations were found in the RM group. Compared with the pregnancy group, expression of AT1R and AT2R were significantly lower in all compartments, but only AT1R/AT2R ratio was significantly higher in the stroma of the non-pregnancy group. Similarly, endometrium arteriole MVD was also significantly lower and negatively correlated with the AT1R/AT2R ratio in the stroma of the non-pregnancy group.ConclusionLocal renin-angiotensin system is dysregulated in peri-implantation endometrium and associated with abnormal angiogenesis in RIF and poor implantation outcome after embryo transfer. |
| first_indexed | 2024-03-12T12:17:47Z |
| format | Article |
| id | doaj.art-ac7398624b894fba9e9d07d72abae4fd |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-12T12:17:47Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-ac7398624b894fba9e9d07d72abae4fd2023-08-30T08:46:18ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-08-011410.3389/fendo.2023.12063261206326Association of angiotensin II and receptors in peri-implantation endometrium with microvessel density and pregnancy outcomes of women with recurrent implantation failure after embryo transferRuofan Qi0Tao Zhang1Yingying Zhang2Jacqueline Pui Wah Chung3Wen-Jui Yang4Wen-Jui Yang5Chi Chiu Wang6Chi Chiu Wang7Chi Chiu Wang8Chi Chiu Wang9Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaDepartment of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaDepartment of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaDepartment of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaDepartment of Infertility and Reproductive Medicine, Taiwan IVF Group Center, Hsinchu, TaiwanDepartment of Fertility and Reproductive Medicine, Ton-Yen General Hospital, Hsinchu, TaiwanDepartment of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaReproduction and Development Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaChinese University of Hong Kong -Sichuan University Joint Laboratory in Reproductive Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaPurposeInvestigate whether local angiotensin II (AngII) and its AngII type 1 and 2 receptors (AT1R, AT2R) in the endometrium are different and correlate with microvessel density in women with reproductive failure and pregnancy outcomes.MethodsEndometrium during the window of implantation from 40 women with recurrent miscarriage (RM) and 40 with recurrent implantation failure (RIF) were compared with 27 fertile women. Peri-implantation endometrium from 54 women prior to euploid embryo transfer were collected and compared in women with successful pregnancy and unsuccessful pregnancy.ResultsCompared with fertile women, expression of AT2R was significantly lower, while AT1R/AT2R expression ratio was significantly higher in the stroma of the RIF group. Endometrium arteriole MVD was significantly lower and negatively correlated with the AT1R/AT2R expression ratio in the stroma of the RIF group. No significant differences and correlations were found in the RM group. Compared with the pregnancy group, expression of AT1R and AT2R were significantly lower in all compartments, but only AT1R/AT2R ratio was significantly higher in the stroma of the non-pregnancy group. Similarly, endometrium arteriole MVD was also significantly lower and negatively correlated with the AT1R/AT2R ratio in the stroma of the non-pregnancy group.ConclusionLocal renin-angiotensin system is dysregulated in peri-implantation endometrium and associated with abnormal angiogenesis in RIF and poor implantation outcome after embryo transfer.https://www.frontiersin.org/articles/10.3389/fendo.2023.1206326/fullendometriumreceptivityrenin angiotensin systemangiogenesisimplantation |
| spellingShingle | Ruofan Qi Tao Zhang Yingying Zhang Jacqueline Pui Wah Chung Wen-Jui Yang Wen-Jui Yang Chi Chiu Wang Chi Chiu Wang Chi Chiu Wang Chi Chiu Wang Association of angiotensin II and receptors in peri-implantation endometrium with microvessel density and pregnancy outcomes of women with recurrent implantation failure after embryo transfer Frontiers in Endocrinology endometrium receptivity renin angiotensin system angiogenesis implantation |
| title | Association of angiotensin II and receptors in peri-implantation endometrium with microvessel density and pregnancy outcomes of women with recurrent implantation failure after embryo transfer |
| title_full | Association of angiotensin II and receptors in peri-implantation endometrium with microvessel density and pregnancy outcomes of women with recurrent implantation failure after embryo transfer |
| title_fullStr | Association of angiotensin II and receptors in peri-implantation endometrium with microvessel density and pregnancy outcomes of women with recurrent implantation failure after embryo transfer |
| title_full_unstemmed | Association of angiotensin II and receptors in peri-implantation endometrium with microvessel density and pregnancy outcomes of women with recurrent implantation failure after embryo transfer |
| title_short | Association of angiotensin II and receptors in peri-implantation endometrium with microvessel density and pregnancy outcomes of women with recurrent implantation failure after embryo transfer |
| title_sort | association of angiotensin ii and receptors in peri implantation endometrium with microvessel density and pregnancy outcomes of women with recurrent implantation failure after embryo transfer |
| topic | endometrium receptivity renin angiotensin system angiogenesis implantation |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1206326/full |
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