Metabolic Stress Induces Caspase-3 Mediated Degradation and Inactivation of Farnesyl and Geranylgeranyl Transferase Activities in Pancreatic β-Cells

Metabolic Stress Induces Caspase-3 Mediated Degradation and Inactivation of Farnesyl and Geranylgeranyl Transferase Activities in Pancreatic β-Cells

Background/Aims: At least 300 prenylated proteins are identified in the human genome; the majority of which partake in a variety of cellular processes including growth, differentiation, cytoskeletal organization/dynamics and vesicle trafficking. Aberrant prenylation of proteins is implicated in huma...

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Bibliographic Details
Main Authors: Rajakrishnan Veluthakal, Daleep K. Arora, Marc L. Goalstone, Renu A. Kowluru, Anjaneyulu Kowluru
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Metabolic stress
Islet β-cell
Farnesylation
Geranylgeranylation
G-proteins
Online Access:http://www.karger.com/Article/FullText/447907

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