The emerging role of circular RNAs in spinal cord injury
Spinal cord injury (SCI) is one kind of severe diseases with high mortality and morbidity worldwide, and lacks effective therapeutic interventions currently, which leads to not only permanent neurological impairments but also heavy social and economic burden. Recent studies have proved that circRNAs...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Journal of Orthopaedic Translation |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214031X21000462 |
| _version_ | 1818826347274829824 |
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| author | Peng Peng Hao Yu Yongjin Li Jingyuan Huang Shengyu Yao Cong Xing Weixiao Liu Bin Zhang Shiqing Feng |
| author_facet | Peng Peng Hao Yu Yongjin Li Jingyuan Huang Shengyu Yao Cong Xing Weixiao Liu Bin Zhang Shiqing Feng |
| author_sort | Peng Peng |
| collection | DOAJ |
| description | Spinal cord injury (SCI) is one kind of severe diseases with high mortality and morbidity worldwide, and lacks effective therapeutic interventions currently, which leads to not only permanent neurological impairments but also heavy social and economic burden. Recent studies have proved that circRNAs are highly expressed in neural tissues, regulating the neuronal and synaptic functions. What's more, significantly altered circRNAs expression profiles are closely associated with the pathophysiology of SCI. In this review, we summarize the current advance on the role of circRNAs in SCI, which may provide a better understanding of pathogenesis and therapeutic strategies of SCI. The Translational potential of this article: The Translational potential of this article is that A further understanding of circRNAs in the pathogenesis of SCI will promote the circRNA-based clinical applications. |
| first_indexed | 2024-12-19T00:26:13Z |
| format | Article |
| id | doaj.art-ac77f3e8d26748039d6f4107fa9c7435 |
| institution | Directory Open Access Journal |
| issn | 2214-031X |
| language | English |
| last_indexed | 2024-12-19T00:26:13Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Orthopaedic Translation |
| spelling | doaj.art-ac77f3e8d26748039d6f4107fa9c74352022-12-21T20:45:16ZengElsevierJournal of Orthopaedic Translation2214-031X2021-09-013015The emerging role of circular RNAs in spinal cord injury Peng Peng0Hao Yu1 Yongjin Li2Jingyuan Huang3Shengyu Yao4Cong Xing5Weixiao Liu6Bin Zhang7Shiqing Feng8Department of Orthopedics, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin, 300052, China; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury,Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Orthopedics, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin, 300052, China; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury,Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Orthopedics, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin, 300052, China; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury,Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Orthopedics, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin, 300052, China; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury,Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Orthopedics, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin, 300052, China; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury,Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Orthopedics, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin, 300052, China; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury,Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Orthopedics, Kuancheng Manzu Autonomous Country Hospital, Chengde, ChinaDepartment of Orthopedics, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin, 300052, China; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury,Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Orthopedics, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin, 300052, China; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury,Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China; Corresponding author. International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord Injury, Department of Orthopedics, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin, 300052, China.Spinal cord injury (SCI) is one kind of severe diseases with high mortality and morbidity worldwide, and lacks effective therapeutic interventions currently, which leads to not only permanent neurological impairments but also heavy social and economic burden. Recent studies have proved that circRNAs are highly expressed in neural tissues, regulating the neuronal and synaptic functions. What's more, significantly altered circRNAs expression profiles are closely associated with the pathophysiology of SCI. In this review, we summarize the current advance on the role of circRNAs in SCI, which may provide a better understanding of pathogenesis and therapeutic strategies of SCI. The Translational potential of this article: The Translational potential of this article is that A further understanding of circRNAs in the pathogenesis of SCI will promote the circRNA-based clinical applications.http://www.sciencedirect.com/science/article/pii/S2214031X21000462CircRNAsSpinal cord injuryNerve regeneration |
| spellingShingle | Peng Peng Hao Yu Yongjin Li Jingyuan Huang Shengyu Yao Cong Xing Weixiao Liu Bin Zhang Shiqing Feng The emerging role of circular RNAs in spinal cord injury Journal of Orthopaedic Translation CircRNAs Spinal cord injury Nerve regeneration |
| title | The emerging role of circular RNAs in spinal cord injury |
| title_full | The emerging role of circular RNAs in spinal cord injury |
| title_fullStr | The emerging role of circular RNAs in spinal cord injury |
| title_full_unstemmed | The emerging role of circular RNAs in spinal cord injury |
| title_short | The emerging role of circular RNAs in spinal cord injury |
| title_sort | emerging role of circular rnas in spinal cord injury |
| topic | CircRNAs Spinal cord injury Nerve regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2214031X21000462 |
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